{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T11:12:43Z","timestamp":1782213163076,"version":"3.54.5"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T00:00:00Z","timestamp":1740528000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,2,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The diagnostic evaluation of ring-enhancing brain lesions (REBLs) is challenging, especially in immunocompromised patients. We conducted a retrospective study to describe the clinicodemographic and radiological features among patients presenting with REBLs to a tertiary referral center.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Radiological reports of all patients who underwent brain computed tomography or magnetic resonance (MR) imaging between 1 November 2013 and 31 October 2017 were filtered for terms indicative of REBLs. Infectious diseases physicians reviewed the medical records to confirm the diagnosis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Over the 4-year study period, there were 42 patients with infective REBLs and 249 with neoplastic REBLs. Pyogenic brain abscesses (PBAs) (20 of 42 [47.6%]) were the most common cause of infective REBLs, followed by tuberculous brain abscesses (TBAs) (9 of 42 [21.4%]) and Nocardia brain abscesses (NBAs) (6 of 42 [14.3%]). The patients were predominantly male, with a mean age of 55.2 years. Fewer than half were febrile at presentation. Cerebrospinal fluid investigations established the microbiological diagnosis in fewer than half of those who underwent lumbar puncture or extraventricular drain insertion. Conversely, brain biopsy yielded the microbiological diagnosis in almost all patients (16 of 17) who underwent the operation. Median white blood cell counts and C-reactive protein were higher in those with PBAs or NBAs than in those with TBAs. All with PBAs and NBAs who underwent MR imaging had diffusion-weighted imaging\u2013hyperintense lesions, compared with only about half of those with TBAs.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Our study has revealed important distinguishing features between infective REBLs and neoplastic REBLs and between PBAs, TBAs, and NBAs.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ofid\/ofaf095","type":"journal-article","created":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T20:50:13Z","timestamp":1741121413000},"source":"Crossref","is-referenced-by-count":4,"title":["Clinicodemographic and Radiological Features of Infective Ring-Enhancing Brain Lesions: A 4-Year Retrospective Study at a Tertiary Referral Center"],"prefix":"10.1093","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6522-2614","authenticated-orcid":false,"given":"Edwin Chong Yu","family":"Sng","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, Changi General Hospital ,","place":["Singapore"]},{"name":"Duke\u2013NUS Medical School ,","place":["Singapore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7603-7334","authenticated-orcid":false,"given":"Ling Ling","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology, Singapore General Hospital ,","place":["Singapore"]},{"name":"Duke\u2013NUS Medical School ,","place":["Singapore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edwin Philip","family":"Conceicao","sequence":"additional","affiliation":[{"name":"Department of Infection Control, Changi General Hospital ,","place":["Singapore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Jia","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology, Singapore General 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