{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T20:05:19Z","timestamp":1776715519264,"version":"3.51.2"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T00:00:00Z","timestamp":1741046400000},"content-version":"vor","delay-in-days":4,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,2,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Fasciola gigantica is the causal agent of human fascioliasis, which is emerging in southern Asia and increasingly reported in Africa. Unfortunately, knowledge of the clinical picture by F gigantica is insufficient, because of the sporadic individual case reports, or few case series of short number of patients from areas where the 2 genetically pure fasciolid species geographically overlap and specific causality was not verified.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The clinical picture is assessed from patients examined in well-equipped hospitals of big cities in Vietnam. Records of 3250 Fasciola-infected patients were registered in individual cards and a database for their complete analysis was constructed. Case profile was based on typical symptoms, blood eosinophilia, serological test, imaging techniques, Kato-Katz test, and ex juvantibus confirmation. Anamnesis furnished information about place of residence, professional activities, and infection source.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Symptoms, signs, and manifestations, including neurological, meningeal, neuropsychic, and ocular disorders, are analyzed according to frequency, sex, and age groups. Early patient diagnosis and treatment facilitated by radio broadcasting underlie differences between serological positivity, coprological positivity, and liver lesions and explain the absence of severe long-term complications and posttreatment sequelae.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>This is the first sufficiently wide study of the clinical picture caused by F gigantica. The assessment has been made in a population without previous contact with fascioliasis and shows that F gigantica (and F gigantica\u2013like hybrids) do not cause clinical pictures different from those caused by Fasciola hepatica. This clinical picture will be useful for physicians and health officers in endemic areas of Asia and Africa.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ofid\/ofaf116","type":"journal-article","created":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T02:08:03Z","timestamp":1741140483000},"source":"Crossref","is-referenced-by-count":5,"title":["The Clinical Picture Caused by <i>Fasciola gigantica<\/i>: Analysis of 3250 Patients Along the 1995\u20132019 Countrywide Spread in Vietnam"],"prefix":"10.1093","volume":"12","author":[{"given":"Nguyen Van","family":"De","sequence":"first","affiliation":[{"name":"Department of Parasitology, Ha Noi Medical University , Ha Noi ,","place":["Vietnam"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pham Ngoc","family":"Minh","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Ha Noi Medical University , Ha Noi ,","place":["Vietnam"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3841-368X","authenticated-orcid":false,"given":"Thanh Hoa","family":"Le","sequence":"additional","affiliation":[{"name":"Vietnam Academy of Science and Technology, Institute of Biotechnology , Ha Noi ,","place":["Vietnam"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Do Trung","family":"Dung","sequence":"additional","affiliation":[{"name":"Institute of Malariology, Parasitology and Entomology , Ha Noi ,","place":["Vietnam"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tran Thanh","family":"Duong","sequence":"additional","affiliation":[{"name":"Institute of Malariology, Parasitology and Entomology , Ha Noi ,","place":["Vietnam"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bui Van","family":"Tuan","sequence":"additional","affiliation":[{"name":"Quy Nhon Institute of Malariology, Parasitology and Entomology , Quy Nhon ,","place":["Vietnam"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Le Thanh","family":"Dong","sequence":"additional","affiliation":[{"name":"Ho Chi Minh Institute of Malariology, Parasitology and Entomology , Ho Chi Minh ,","place":["Vietnam"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nguyen Van","family":"Vinh Chau","sequence":"additional","affiliation":[{"name":"Research Direction, Ho Chi Minh Hospital of Tropical Diseases , Ho Chi Minh City ,","place":["Vietnam"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6699-7382","authenticated-orcid":false,"given":"Pablo F","family":"Cuervo","sequence":"additional","affiliation":[{"name":"Departamento de Parasitolog\u00eda, Facultad de Farmacia, Universidad de Valencia , Burjassot, Valencia ,","place":["Spain"]},{"name":"Consorcio Centro de Investigacion Biomedica en Red de Enfermedades Infecciosas, Instituto de Salud Carlos III , Madrid ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2347-7269","authenticated-orcid":false,"given":"M Dolores","family":"Bargues","sequence":"additional","affiliation":[{"name":"Departamento de Parasitolog\u00eda, Facultad de Farmacia, Universidad de Valencia , Burjassot, Valencia ,","place":["Spain"]},{"name":"Consorcio Centro de Investigacion Biomedica en Red de Enfermedades Infecciosas, Instituto de Salud Carlos III , Madrid ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1584-8330","authenticated-orcid":false,"given":"M Adela","family":"Valero","sequence":"additional","affiliation":[{"name":"Departamento de Parasitolog\u00eda, Facultad de Farmacia, Universidad de Valencia , Burjassot, Valencia ,","place":["Spain"]},{"name":"Consorcio Centro de Investigacion Biomedica en Red de Enfermedades Infecciosas, Instituto de Salud Carlos III , Madrid ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2266-6295","authenticated-orcid":false,"given":"Albis Francesco","family":"Gabrielli","sequence":"additional","affiliation":[{"name":"Global Neglected Tropical Diseases Programme, World Health Organization , Geneva ,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Montresor","sequence":"additional","affiliation":[{"name":"Global Neglected Tropical Diseases Programme, World Health Organization , Geneva ,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1685-7004","authenticated-orcid":false,"given":"Santiago","family":"Mas-Coma","sequence":"additional","affiliation":[{"name":"Departamento de Parasitolog\u00eda, Facultad de Farmacia, Universidad de Valencia , Burjassot, Valencia ,","place":["Spain"]},{"name":"Consorcio Centro de Investigacion 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