{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T10:22:12Z","timestamp":1787739732920,"version":"build-2784847793"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T00:00:00Z","timestamp":1742256000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000865","name":"Gates Foundation","doi-asserted-by":"publisher","award":["OPP1189053"],"award-info":[{"award-number":["OPP1189053"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000865","name":"Gates Foundation","doi-asserted-by":"publisher","award":["INV-010426"],"award-info":[{"award-number":["INV-010426"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001713","name":"European and Developing Countries Clinical Trials Partnership 2","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001713","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Union","doi-asserted-by":"publisher","award":["RIA2018V-2304-PREPARE"],"award-info":[{"award-number":["RIA2018V-2304-PREPARE"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,3,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Child survival rates have improved globally, but neonatal mortality due to infections, such as group B Streptococcus (GBS), remains a significant concern. The global burden of GBS-related morbidity and mortality is substantial. However, data from low and middle-income countries are lacking. Vaccination during pregnancy could be a feasible strategy to address GBS-related disease burden.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We assessed maternal rectovaginal GBS colonization and neonatal disease rates in a prospective cohort of 6062 women\u2013infant pairs. Surveillance for invasive infant disease occurred in parallel at 2 Kampala hospital sites. In a nested case-control study, we identified infants &amp;lt;90 days of age with invasive GBS disease (iGBS) (n = 24) and healthy infants born to mothers colonized with GBS (n = 72). We measured serotype-specific anticapsular immunoglobulin G (IgG) in cord blood\/infant sera using a validated multiplex Luminex assay.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We found a high incidence of iGBS (1.0 per 1000 live births) within the first 90 days of life across the surveillance sites, associated with a high case fatality rate (18.2%). Maternal GBS colonization prevalence was consistent with other studies in the region (14.7% [95% confidence interval, 13.7%\u201315.6%]). IgG geometric mean concentrations were lower in cases than controls for serotypes Ia (0.005 vs 0.12\u2005\u00b5g\/mL; P = .05) and III (0.011 vs 0.036\u2005\u00b5g\/mL; P = .07) and in an aggregate analysis of all serotypes (0.014 vs 0.05\u2005\u00b5g\/mL; P = .02).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We found that GBS is an important cause of neonatal and young infant disease in Uganda and confirmed that maternally derived antibodies were lower in early-onset GBS cases than in healthy exposed controls.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ofid\/ofaf167","type":"journal-article","created":{"date-parts":[[2025,3,16]],"date-time":"2025-03-16T08:13:53Z","timestamp":1742112833000},"source":"Crossref","is-referenced-by-count":6,"title":["Epidemiology of Group B\n                    <i>Streptococcus<\/i>\n                    : Maternal Colonization and Infant Disease in Kampala, Uganda"],"prefix":"10.1093","volume":"12","author":[{"given":"Mary","family":"Kyohere","sequence":"first","affiliation":[{"name":"Makerere University\u2013Johns Hopkins University Research Collaboration , Kampala ,","place":["Uganda"]},{"name":"Centre for Neonatal and Paediatric Infection, Institute of Infection and Immunity, City St George's, University of London , London ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah Georgia","family":"Davies","sequence":"additional","affiliation":[{"name":"Centre for Neonatal and Paediatric Infection, Institute of Infection and Immunity, City St George's, University of London , London ,","place":["United Kingdom"]},{"name":"Clinical Research Unit, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine , London ,","place":["United 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