{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:54:40Z","timestamp":1790816080569,"version":"4.1.0"},"reference-count":59,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T00:00:00Z","timestamp":1744243200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"European Union\u2019s Horizon 2020 Research and Innovation Programme"},{"name":"Marie Sklowdowska-Curie Grant Agreement OrganoVIR","award":["812673"],"award-info":[{"award-number":["812673"]}]},{"name":"European Union\u2019s Horizon 2020 Research and Innovation Programme","award":["953201"],"award-info":[{"award-number":["953201"]}]},{"name":"Public\u2013Private Partnership"},{"DOI":"10.13039\/100016036","name":"Health Holland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016036","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,4,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Enteroviruses (EV) usually cause acute, mild, self-limiting disease. Chronic infections with EVs are rare, and typically occur in patients with immunodeficiency, posing a high risk of severe outcomes. We report a rare case of chronic diarrhea caused by coxsackievirus A1 (CVA1) (from EV-C species) infection in a patient with a common variable immunodeficiency, who was on treatment with pooled intravenous immunoglobulin (IVIG) from the Netherlands. To explore treatment options, we assessed the presence of neutralizing antibodies (nAbs) against CVA1 in pooled IVIG from South Africa, where EV-Cs are prevalent, and tested the antiviral efficacy of US Food and Drug Administration\u2013approved drugs like fluoxetine, itraconazole, ribavirin, and remdesivir (RDV) against CVA1 in vitro. Both Dutch and South African IVIG showed low nAb titers against CVA1. The patient, treated with Dutch IVIG, also received a combination of amantadine and fluoxetine, which were discontinued due to side effects. Among the drugs tested, only RDV significantly inhibited CVA1 replication in rhabdomyosarcoma (RD) cells. This in vitro efficacy was not reflected by a favorable clinical response after treatment of the patient with RDV. In concordance with unfavorable antiviral response in the patient, preliminary tests on a co-culture model containing isogenic human intestinal cells and intestinal fibroblasts showed no significant reduction in CVA1 RNA copies after RDV administration. In conclusion, our results showed that repurposing of drugs that have shown in vitro efficacy does not translate well to the patients, and this is also reflected in a more physiologically relevant model of the human intestine.<\/jats:p>","DOI":"10.1093\/ofid\/ofaf212","type":"journal-article","created":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T14:24:56Z","timestamp":1744295096000},"source":"Crossref","is-referenced-by-count":4,"title":["Toward Personalized Medicine: The Effect of Treatment of Chronic Enterovirus Diarrhea in an Immunocompromised Patient and the Correlation With In Vitro Models"],"prefix":"10.1093","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3623-897X","authenticated-orcid":false,"given":"Giulia","family":"Moreni","sequence":"first","affiliation":[{"name":"Department of Medical Microbiology, OrganoVIR Labs, Amsterdam UMC, Academic Medical Center, University of Amsterdam, Amsterdam Institute for Infection and Immunity , Amsterdam ,","place":["The Netherlands"]},{"name":"Department of Pediatric Infectious Diseases, OrganoVIR Labs, Amsterdam UMC, Academic Medical Center, University of Amsterdam, Amsterdam Institute for Infection and Immunity, Emma Children\u2019s Hospital , Amsterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9751-1162","authenticated-orcid":false,"given":"Carlemi","family":"Calitz","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, OrganoVIR Labs, Amsterdam UMC, Academic Medical Center, University of Amsterdam, Amsterdam Institute for Infection and Immunity , Amsterdam ,","place":["The Netherlands"]},{"name":"Department of Pediatric Infectious Diseases, OrganoVIR Labs, Amsterdam UMC, Academic Medical Center, University of Amsterdam, Amsterdam Institute for Infection and Immunity, Emma Children\u2019s Hospital , Amsterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerrit","family":"Koen","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, OrganoVIR Labs, Amsterdam UMC, Academic Medical Center, University of Amsterdam, Amsterdam Institute for Infection and Immunity , Amsterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hetty","family":"van Eijk","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, OrganoVIR Labs, Amsterdam UMC, Academic Medical Center, University of Amsterdam, Amsterdam Institute for Infection and Immunity , Amsterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Johannesson","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, OrganoVIR Labs, Amsterdam UMC, Academic Medical Center, University of Amsterdam, Amsterdam Institute for Infection and Immunity , Amsterdam ,","place":["The Netherlands"]},{"name":"Department of Pediatric Infectious Diseases, OrganoVIR Labs, Amsterdam UMC, Academic Medical Center, University of Amsterdam, Amsterdam Institute for Infection and Immunity, Emma Children\u2019s Hospital , Amsterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamy","family":"De Ruijter","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Amsterdam UMC, Vrije Universiteit Amsterdam , Amsterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberley S M","family":"Benschop","sequence":"additional","affiliation":[{"name":"National Institute for Public Health and the Environment , Bilthoven ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeroen","family":"Cremer","sequence":"additional","affiliation":[{"name":"National Institute for Public Health and the Environment , Bilthoven ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5232-8206","authenticated-orcid":false,"given":"Dasja","family":"Pajkrt","sequence":"additional","affiliation":[{"name":"Department of Pediatric Infectious Diseases, OrganoVIR Labs, Amsterdam UMC, Academic Medical Center, University of Amsterdam, Amsterdam Institute for Infection and Immunity, Emma Children\u2019s Hospital , Amsterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2986-4884","authenticated-orcid":false,"given":"Adithya","family":"Sridhar","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, OrganoVIR Labs, Amsterdam UMC, Academic Medical Center, University of Amsterdam, Amsterdam Institute for Infection and Immunity , Amsterdam ,","place":["The Netherlands"]},{"name":"Department of Pediatric Infectious Diseases, OrganoVIR Labs, Amsterdam UMC, Academic Medical Center, University of Amsterdam, Amsterdam Institute for Infection and Immunity, Emma Children\u2019s Hospital , Amsterdam ,","place":["The Netherlands"]},{"name":"Emma Center for Personalized Medicine, Amsterdam UMC , Amsterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3410-1227","authenticated-orcid":false,"given":"Edgar J","family":"Peters","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Internal Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam , Amsterdam ,","place":["The Netherlands"]},{"name":"Infectious Diseases, Amsterdam Institute for Infection and Immunity , Amsterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1617-7049","authenticated-orcid":false,"given":"Katja 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