{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:14:35Z","timestamp":1753877675040,"version":"3.41.2"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T00:00:00Z","timestamp":1744243200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,4,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>We present a unique case involving a patient who was diagnosed with X-linked properdin deficiency after 2 episodes of disseminated gonococcal infections 1 year apart. Although this deficiency is well-documented for its association with meningococcemia, its correlation with disseminated gonococcal infections (DGI) has not been previously reported. Recurrent DGI cases reported in the literature with identified cause are mostly associated with acquired or congenital complement pathway deficiencies. However, properdin deficiency is rarely screened for during a first episode. Our case not only highlights the clinical presentation that should raise suspicion of DGI but also underscores the importance of investigating the alternative complement pathway in such cases. At a time when gonococcal resistance is increasing, it is essential to consider existing strategies for preventing these infections, including vaccinations.<\/jats:p>","DOI":"10.1093\/ofid\/ofaf223","type":"journal-article","created":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T19:40:56Z","timestamp":1744314056000},"source":"Crossref","is-referenced-by-count":0,"title":["Recurrent Gonococcemia Reveiling X-linked Properdin Deficiency: A Novel Case Report"],"prefix":"10.1093","volume":"12","author":[{"given":"Colombe","family":"Chedal-Anglay","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, CHU Henri Mondor , Cr\u00e9teil ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2513-5425","authenticated-orcid":false,"given":"William","family":"Vindrios","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, CHU Henri Mondor , Cr\u00e9teil ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,4,10]]},"reference":[{"key":"2025053002172760600_ofaf223-B1","doi-asserted-by":"crossref","first-page":"548","DOI":"10.2471\/BLT.18.228486","article-title":"Chlamydia, gonorrhoea, trichomoniasis and syphilis: global prevalence and incidence estimates, 2016","volume":"97","author":"Rowley","year":"2019","journal-title":"Bull World Health Organ"},{"key":"2025053002172760600_ofaf223-B2","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.3390\/pathogens11111230","article-title":"Current susceptibility surveillance and distribution of antimicrobial resistance in N. gonorrhoeae within WHO regions","volume":"11","author":"Radovanovic","year":"2022","journal-title":"Pathogens."},{"key":"2025053002172760600_ofaf223-B3","doi-asserted-by":"crossref","first-page":"98","DOI":"10.4161\/viru.26515","article-title":"Meningococcal disease and the complement system","volume":"5","author":"Lewis","year":"2013","journal-title":"Virulence"},{"key":"2025053002172760600_ofaf223-B4","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1046\/j.1365-2249.1999.01056.x","article-title":"Properdin deficiency in a large Swiss family: identification of a stop codon in the properdin gene, and association of meningococcal disease with lack of the IgG2 allotype marker G2m(n)","volume":"118","author":"Sp\u00e4th","year":"1999","journal-title":"Clin Exp Immunol"},{"key":"2025053002172760600_ofaf223-B5","doi-asserted-by":"crossref","first-page":"2587","DOI":"10.1056\/NEJMoa1011205","article-title":"Preexposure chemoprophylaxis for HIV prevention in men who have sex with men","volume":"363","author":"Grant","year":"2010","journal-title":"N Engl J Med"},{"key":"2025053002172760600_ofaf223-B6","doi-asserted-by":"crossref","first-page":"31841","DOI":"10.3402\/jchimp.v6.31841","article-title":"Disseminated gonococcal infection: an unusual presentation","volume":"6","author":"Lohani","year":"2016","journal-title":"J Community Hosp Intern Med Perspect"},{"key":"2025053002172760600_ofaf223-B7","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1097\/00005792-198311000-00005","article-title":"Disseminated gonococcal infection: a prospective analysis of 49 patients and a review of pathophysiology and immune mechanisms","volume":"62","author":"O'Brien","year":"1983","journal-title":"Medicine (Baltimore)"},{"key":"2025053002172760600_ofaf223-B8","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1002\/art.1780250513","article-title":"Gonococcal arthritis\u2013dermatitis syndrome. 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