{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T21:51:31Z","timestamp":1784843491576,"version":"3.55.0"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T00:00:00Z","timestamp":1745884800000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K23-AI177939"],"award-info":[{"award-number":["K23-AI177939"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01-AI143453"],"award-info":[{"award-number":["R01-AI143453"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Charitable Trust"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,4,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Cryptococcosis is an invasive fungal disease that significantly contributes to morbidity and mortality among kidney transplant recipients (KTRs). Although various prognostic factors predictive of mortality have been identified, most research has been limited to single-center and small-scale studies.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We conducted a retrospective cohort study using data from the United States Renal Data System to investigate hospitalizations and outcomes for cryptococcosis among KTRs in the United States from 2006 to 2016. Collected data included demographics, comorbid conditions, hospitalization- and transplant-related complications, and mortality.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 1265 KTRs were hospitalized for cryptococcosis. The mean age was 59.1 \u00b1 11.2 years; 857 (67.7%) were male, 852 (67.4%) were White, 603 (47.7%) resided in the South, and 648 (51.2%) had a diagnosis of cryptococcal meningitis (CM). The overall 6-month mortality rate was 22%. Multivariable logistic regression analyses identified several factors associated with increased 6-month mortality: cirrhosis (adjusted odds ratio [aOR], 3.1; 95% CI, 1.2\u20137.7), intensive care unit admission (aOR, 2.9; 95% CI, 2.0\u20134.0), need for pretransplant dialysis (aOR, 2.7; 95% CI, 1.5\u20134.9), lack of tacrolimus use at follow-up (aOR, 2.2; 95% CI, 1.4\u20133.3), age \u226560 years (aOR, 2.0; 95% CI, 1.4\u20132.8), acute kidney injury (aOR, 1.7; 95% CI, 1.2\u20132.4), post-transplant period exceeding 2 years (aOR, 1.7; 95% CI, 1.1\u20132.4), and previous hospitalization for complications related to the transplanted kidney (aOR, 1.5; 95% CI, 1.1\u20132.2).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Early mortality remains high among KTRs hospitalized for cryptococcosis, with cirrhosis identified as the strongest independent risk factor for mortality.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ofid\/ofaf263","type":"journal-article","created":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T08:33:35Z","timestamp":1745915615000},"source":"Crossref","is-referenced-by-count":3,"title":["High Mortality and Associated Risk Factors in Kidney Transplant Recipients With Cryptococcosis\u2014A Nationwide Cohort Study Over a Decade Using USRDS Data"],"prefix":"10.1093","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-5591-5625","authenticated-orcid":false,"given":"Giuseppe","family":"Fiorica","sequence":"first","affiliation":[{"name":"Department of Medicine, Mount Sinai Hospital , New York, New York ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel E","family":"Cervera-Hernandez","sequence":"additional","affiliation":[{"name":"Sanford Health , Sioux Falls, South Dakota ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7568-2961","authenticated-orcid":false,"given":"Liise-anne","family":"Pirofski","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine and Montefiore Medical Center , Bronx, New York ,","place":["USA"]},{"name":"Department of Microbiology and Immunology, Albert Einstein College of Medicine , Bronx, New York ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vagish S","family":"Hemmige","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine and Montefiore Medical Center , Bronx, New York ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5050-6876","authenticated-orcid":false,"given":"Hyunah","family":"Yoon","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine and Montefiore Medical Center , Bronx, New York ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,4,29]]},"reference":[{"key":"2025052602121103700_ofaf263-B1","doi-asserted-by":"crossref","first-page":"e13543","DOI":"10.1111\/ctr.13543","article-title":"Cryptococcosis in solid organ transplantation-guidelines from the American Society of Transplantation Infectious Diseases Community of Practice","volume":"33","author":"Baddley","year":"2019","journal-title":"Clin Transplant"},{"key":"2025052602121103700_ofaf263-B2","first-page":"61","article-title":"Cryptococcal infections in 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