{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:14:44Z","timestamp":1753877684913,"version":"3.41.2"},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T00:00:00Z","timestamp":1749168000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Epstein-Barr virus\u2013associated smooth-muscle tumor (EBV-SMT) is a rare tumor that occurs in immunosuppressed individuals. Among people living with human immunodeficiency virus (HIV), opportunistic infections are more likely to determine prognosis than EBV-SMT itself. Herein, we describe a patient with HIV whose airway became obstructed due to one of the multiple tumor nodules of EBV-SMT. This 36-year-old woman living with advanced HIV presented with sudden dyspnea. On presentation, she experienced respiratory failure due to airway obstruction, requiring an emergency tracheostomy. Examinations revealed multiple lesions in the right patella, 12th thoracic vertebra, and upper glottis, all diagnosed as EBV-SMT. Despite antiretroviral therapy, surgical interventions were required for disease control. She has remained recurrence free for &amp;gt;3 years after resection. Although EBV-SMT is generally considered an indolent tumor, this case demonstrates that it can cause life-threatening complications, for which a timely multidisciplinary team approach is most crucial.<\/jats:p>","DOI":"10.1093\/ofid\/ofaf325","type":"journal-article","created":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T13:13:04Z","timestamp":1749215584000},"source":"Crossref","is-referenced-by-count":0,"title":["A Case of Life-Threatening Airway Obstruction Due to Epstein-Barr Virus\u2013Associated Smooth Muscle Tumor With HIV Infection"],"prefix":"10.1093","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-4253-6120","authenticated-orcid":false,"given":"Yuka","family":"Kudo-Nagata","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital , Bunkyo-ku, Tokyo ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8986-6879","authenticated-orcid":false,"given":"Kazuaki","family":"Fukushima","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital , Bunkyo-ku, Tokyo ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taro","family":"Sugimoto","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital , Bunkyo-ku, Tokyo ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomotake","family":"Okuma","sequence":"additional","affiliation":[{"name":"Department of Musculoskeletal Oncology, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital , Bunkyo-ku, Tokyo ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Hozumi","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital , Bunkyo-ku, Tokyo ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toru","family":"Motoi","sequence":"additional","affiliation":[{"name":"Department of Pathology, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital , Bunkyo-ku, Tokyo ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akifumi","family":"Imamura","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital , Bunkyo-ku, Tokyo ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,6,6]]},"reference":[{"key":"2025070209014030900_ofaf325-B1","doi-asserted-by":"crossref","first-page":"2391","DOI":"10.2169\/internalmedicine.53.2674","article-title":"Epstein-Barr virus-associated smooth muscle tumors in AIDS patients: a largest case (series)","volume":"53","author":"Issarachaikul","year":"2014","journal-title":"Intern Med"},{"key":"2025070209014030900_ofaf325-B2","first-page":"190","volume-title":"Soft tissue and bone tumours. 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soft tissue: selected changes and new entities","volume":"28","author":"Choi","year":"2021","journal-title":"Adv Anat Pathol"},{"key":"2025070209014030900_ofaf325-B6","doi-asserted-by":"crossref","first-page":"718","DOI":"10.5858\/arpa.2015-0120-RS","article-title":"Epstein-Barr virus-associated smooth muscle tumor","volume":"140","author":"Dekate","year":"2016","journal-title":"Arch Pathol Lab Med"},{"key":"2025070209014030900_ofaf325-B7","first-page":"561548","article-title":"AIDS-related EBV-associated smooth muscle tumors: a review of 64 published cases","volume":"2011","author":"Purgina","year":"2011","journal-title":"Patholog Res Int"},{"key":"2025070209014030900_ofaf325-B8","doi-asserted-by":"crossref","first-page":"13596535221126828","DOI":"10.1177\/13596535221126828","article-title":"Antiretroviral therapy achieved metabolic complete remission of hepatic AIDS related Epstein-Barr virus-associated smooth muscle 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