{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T02:36:08Z","timestamp":1791513368882,"version":"4.3.4"},"reference-count":12,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T00:00:00Z","timestamp":1749600000000},"content-version":"vor","delay-in-days":11,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["2KL2TR001870"],"award-info":[{"award-number":["2KL2TR001870"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["5R37AI098472"],"award-info":[{"award-number":["5R37AI098472"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,5,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Lenacapavir, a long-acting human immunodeficiency virus (HIV) capsid inhibitor, is thought to have a low resistance barrier based on current, limited data. We describe 4 patients experiencing homelessness with severe mental illness who maintained HIV suppression (&amp;lt;30\u2005copies\/mL) despite unintentional receipt of lenacapavir monotherapy for 9\u201338 weeks, highlighting its potential among adherence-challenged populations.<\/jats:p>","DOI":"10.1093\/ofid\/ofaf330","type":"journal-article","created":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T07:25:13Z","timestamp":1749626713000},"source":"Crossref","is-referenced-by-count":2,"title":["HIV Viral Suppression With Unintentional Lenacapavir Monotherapy in Adherence-Challenged Patients: A Case Series"],"prefix":"10.1093","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4277-6889","authenticated-orcid":false,"given":"Nicky J","family":"Mehtani","sequence":"first","affiliation":[{"name":"Division of General Internal Medicine, University of California, San Francisco , San Francisco, California ,","place":["USA"]},{"name":"Whole Person Integrated Care, San Francisco Department of Public Health , San Francisco, California ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet","family":"Grochowski","sequence":"additional","affiliation":[{"name":"Division of HIV, Infectious Diseases and Global Medicine, University of California, San Francisco , San Francisco, California ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthonia","family":"Chimezie","sequence":"additional","affiliation":[{"name":"Division of HIV, Infectious Diseases and Global Medicine, University of California, San Francisco , San Francisco, California ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alix","family":"Strough","sequence":"additional","affiliation":[{"name":"Whole Person Integrated Care, San Francisco Department of Public Health , San Francisco, California ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Strieff","sequence":"additional","affiliation":[{"name":"Whole Person Integrated Care, San Francisco Department of Public Health , San Francisco, California ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6674-5388","authenticated-orcid":false,"given":"Monica","family":"Gandhi","sequence":"additional","affiliation":[{"name":"Division of HIV, Infectious Diseases and Global Medicine, University of California, San Francisco , San Francisco, California ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,6,11]]},"reference":[{"key":"2025062612025268700_ofaf330-B1","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.2105\/AJPH.2015.302905","article-title":"Housing status, medical care, and health outcomes among people living with HIV\/AIDS: a systematic review","volume":"106","author":"Aidala","year":"2016","journal-title":"Am J Public Health"},{"key":"2025062612025268700_ofaf330-B2","doi-asserted-by":"crossref","first-page":"969","DOI":"10.7326\/M23-0788","article-title":"Demonstration project of long-acting antiretroviral therapy in a diverse population of people with HIV","volume":"176","author":"Gandhi","year":"2023","journal-title":"Ann Intern Med"},{"key":"2025062612025268700_ofaf330-B3","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1097\/QAI.0000000000003396","article-title":"Feasibility of implementing a low-barrier long-acting injectable antiretroviral program for HIV treatment and prevention for people experiencing homelessness","volume":"96","author":"Mehtani","year":"2024","journal-title":"J Acquir Immune Defic Syndr"},{"key":"2025062612025268700_ofaf330-B4","doi-asserted-by":"crossref","first-page":"ofae125","DOI":"10.1093\/ofid\/ofae125","article-title":"Case series of people with HIV on the long-acting combination of lenacapavir and cabotegravir: call for a trial","volume":"11","author":"Gandhi","year":"2024","journal-title":"Open Forum Infect Dis"},{"key":"2025062612025268700_ofaf330-B5","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1001\/jama.2025.0109","article-title":"HIV viral suppression on long-acting antiretroviral therapy in those with and without initial viremia","volume":"333","author":"Spinelli","year":"2025","journal-title":"JAMA"},{"key":"2025062612025268700_ofaf330-B6","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1093\/cid\/ciae500","article-title":"Viral suppression rates at 48 weeks in people with human immunodeficiency virus starting long-acting cabotegravir\/rilpivirine with initial viremia","volume":"80","author":"Hickey","year":"2025","journal-title":"Clin Infect Dis"},{"key":"2025062612025268700_ofaf330-B7","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1001\/jama.2024.2985","article-title":"IAS-USA Treatment Guidelines Panel. Updated treatment recommendation on use of cabotegravir and rilpivirine for people with HIV from the IAS-USA guidelines panel","volume":"331","author":"Sax","year":"2024","journal-title":"JAMA"},{"key":"2025062612025268700_ofaf330-B8","author":"Panel on Antiretroviral Guidelines for Adults and Adolescents"},{"key":"2025062612025268700_ofaf330-B9","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1056\/NEJMoa2115542","article-title":"Capsid inhibition with lenacapavir in multidrug-resistant HIV-1 infection","volume":"386","author":"Segal-Maurer","year":"2022","journal-title":"N Engl J Med"},{"key":"2025062612025268700_ofaf330-B10","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1093\/infdis\/jiaf050","article-title":"Resistance analyses in heavily treatment-experienced people with HIV treated with the novel HIV capsid inhibitor lenacapavir after 2 years","volume":"231","author":"Margot","year":"2025","journal-title":"J Infect Dis"},{"key":"2025062612025268700_ofaf330-B11","doi-asserted-by":"crossref","first-page":"ciae631","DOI":"10.1093\/cid\/ciae631","article-title":"Virologic failure and emergent integrase strand transfer inhibitor drug resistance with long acting cabotegravir for HIV treatment: a meta-analysis [manuscript published online ahead of print 26 December 2024]","author":"Perez Navarro","year":"2024","journal-title":"Clin Infect Dis"},{"key":"2025062612025268700_ofaf330-B12","doi-asserted-by":"crossref","first-page":"100793","DOI":"10.1016\/j.lanepe.2023.100793","article-title":"Real-world trough concentrations and effectiveness of long-acting cabotegravir and rilpivirine: a multicenter prospective observational study in Switzerland","volume":"36","author":"Thoueille","year":"2023","journal-title":"Lancet Reg Health Eur"}],"container-title":["Open Forum Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ofid\/advance-article-pdf\/doi\/10.1093\/ofid\/ofaf330\/63465707\/ofaf330.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ofid\/article-pdf\/12\/6\/ofaf330\/63465707\/ofaf330.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ofid\/article-pdf\/12\/6\/ofaf330\/63465707\/ofaf330.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T16:02:59Z","timestamp":1750953779000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ofid\/article\/doi\/10.1093\/ofid\/ofaf330\/8160119"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,31]]},"references-count":12,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,5,31]]}},"URL":"https:\/\/doi.org\/10.1093\/ofid\/ofaf330","relation":{},"ISSN":["2328-8957"],"issn-type":[{"value":"2328-8957","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,6]]},"published":{"date-parts":[[2025,5,31]]},"article-number":"ofaf330"}}