{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:04:27Z","timestamp":1753877067394,"version":"3.41.2"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T00:00:00Z","timestamp":1750291200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Disseminated histoplasmosis is more common in patients with impaired immune function, with HIV infection being a recognized risk factor for its development. In this patient group, diagnosis poses a challenge due to the nonspecific clinical picture. We aimed to develop a diagnostic predictive scale for disseminated histoplasmosis in patients with HIV.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We analyzed records from 2 tertiary institutions in the city of Pereira between May 2014 and December 2022. We selected 313 cases of HIV: 90 patients were diagnosed with histoplasmosis and 223 with other opportunistic infections.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Variables associated with the diagnosis of histoplasmosis were hemoglobin &amp;lt;10\u2005g\/dL (odds ratio [OR], 2.0; 95% CI, 1.0\u20134.2; P = .039), leukopenia (OR, 2.2; 95% CI, 1.1\u20134.2; P = .019), elevated lactate dehydrogenase (OR, 2.2; 95% CI, 1.0\u20134.5; P = .034), an aspartate transaminase\/alanine transaminase ratio &amp;gt;2 (OR, 3.8; 95% CI, 2.0\u20137.4; P &amp;lt; .001), and a CD4+ lymphocyte count &amp;lt;50\u2005cells\/\u03bcL (OR, 2.4; 95% CI, 1.2\u20134.6; P = .011). With these parameters, a diagnostic predictive scale was developed. With a cutoff of \u22654 points, it correctly classified 76.7% of cases with a sensitivity of 62.3% and a specificity of 82.9%, with adequate accuracy demonstrated by an area under the receiver operating characteristic curve of 78%.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>This study proposes a simple and cost-effective tool that facilitates timely diagnosis and treatment of histoplasmosis in patients with HIV.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ofid\/ofaf355","type":"journal-article","created":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T17:10:51Z","timestamp":1751044251000},"source":"Crossref","is-referenced-by-count":0,"title":["Development of a Diagnostic Score for Histoplasmosis in a Cohort of Patients With HIV"],"prefix":"10.1093","volume":"12","author":[{"given":"Juli\u00e1n Andr\u00e9s","family":"Hoyos Pulgar\u00edn","sequence":"first","affiliation":[{"name":"Departamento de enfermedades infecciosas, Universidad Tecnol\u00f3gica de Pereira , Pereira ,","place":["Colombia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5210-2517","authenticated-orcid":false,"given":"Germ\u00e1n Alberto","family":"Moreno G\u00f3mez","sequence":"additional","affiliation":[{"name":"Departamento de epidemiolog\u00eda, Universidad Tecnol\u00f3gica de Pereira , Pereira ,","place":["Colombia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3798-0767","authenticated-orcid":false,"given":"Miguel \u00c1ngel","family":"Atehortua Otero","sequence":"additional","affiliation":[{"name":"Departamento de medicina interna, Internal Medicine Interest Group, Universidad Tecnol\u00f3gica de Pereira , Pereira 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