{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T02:10:09Z","timestamp":1788315009953,"version":"build-2803163510"},"reference-count":69,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T00:00:00Z","timestamp":1750291200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI20\/00575"],"award-info":[{"award-number":["PI20\/00575"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Union","doi-asserted-by":"publisher","award":["FI21\/00314"],"award-info":[{"award-number":["FI21\/00314"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Data on the trends of the incidence of candidemia caused by C. albicans and C. parapsilosis in recent years are very limited. At the same time, factors that predispose to candidemia, caused by both species and the epidemiology of hospital transmission, are not well known. Our study analyzed 14 years of candidemia in a single institution in order to compare the incidence, clinical outcomes, and transmission patterns of both species.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We conducted a retrospective study (2010\u20132023) in a 1236-bed tertiary hospital. We included all episodes of candidemia due to C. albicans and C. parapsilosis and collected the epidemiological, clinical, and microbiological characteristics of the patients. Incidence trends were calculated per hospital admission and population. Antifungal susceptibility testing followed European Committee on Antimicrobial Susceptibility Testing guidelines, and genotyping used species-specific microsatellites.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Among 576 episodes of candidemia, 269 (46.7%) were caused by C. albicans and 110 (19.1%) by C. parapsilosis. The incidence of candidemia per 1000 admissions\/y and 100 000 population\/y remained stable for both species. C. parapsilosis affected younger patients with fewer comorbidities and lower mortality than C. albicans. The catheter was the main source in both groups, but genotyping revealed no C. parapsilosis clusters, suggesting the absence of a significant horizontal transmission. We did not have a single episode of fluconazole-resistant C. parapsilosis candidemia.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Our data do not suggest an increasing trend in the incidence of C. albicans and C. parapsilosis candidemia in recent years. Candidemia caused by both species is not significantly transmitted from patient to patient in the hospital. The genotypical distribution of fluconazole-resistant C. parapsilosis should be further studied.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ofid\/ofaf359","type":"journal-article","created":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T14:02:57Z","timestamp":1751032977000},"source":"Crossref","is-referenced-by-count":8,"title":["Trends in Candidemia Over the Last 14 Years: A Comparative Analysis of <i>Candida parapsilosis<\/i> and <i>Candida albicans<\/i>"],"prefix":"10.1093","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7226-8212","authenticated-orcid":false,"given":"Ana","family":"Soriano-Mart\u00edn","sequence":"first","affiliation":[{"name":"Clinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Mara\u00f1\u00f3n , Madrid ,","place":["Spain"]},{"name":"Instituto de Investigaci\u00f3n Sanitaria Hospital Gregorio Mara\u00f1\u00f3n (IiSGM) , Madrid ,","place":["Spain"]},{"name":"CIBER Enfermedades 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Gregorio Mara\u00f1\u00f3n (IiSGM) , Madrid ,","place":["Spain"]},{"name":"Escuela de Doctorado, Universidad de Alcal\u00e1 , Alcal\u00e1 de Henares ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas","family":"Guinea","sequence":"additional","affiliation":[{"name":"Clinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Mara\u00f1\u00f3n , Madrid ,","place":["Spain"]},{"name":"Instituto de Investigaci\u00f3n Sanitaria Hospital Gregorio Mara\u00f1\u00f3n (IiSGM) , Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0609-1305","authenticated-orcid":false,"given":"Elena","family":"Reigadas","sequence":"additional","affiliation":[{"name":"Clinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Mara\u00f1\u00f3n , Madrid ,","place":["Spain"]},{"name":"Instituto de Investigaci\u00f3n Sanitaria Hospital Gregorio Mara\u00f1\u00f3n (IiSGM) , Madrid ,","place":["Spain"]},{"name":"Medicine Department, School of Medicine, Universidad Complutense de Madrid , Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paloma","family":"Garc\u00eda-Clemente","sequence":"additional","affiliation":[{"name":"Clinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Mara\u00f1\u00f3n , Madrid ,","place":["Spain"]},{"name":"Instituto de Investigaci\u00f3n Sanitaria Hospital Gregorio Mara\u00f1\u00f3n (IiSGM) , Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilio","family":"Bouza","sequence":"additional","affiliation":[{"name":"Clinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Mara\u00f1\u00f3n , Madrid ,","place":["Spain"]},{"name":"Instituto de Investigaci\u00f3n Sanitaria Hospital Gregorio Mara\u00f1\u00f3n (IiSGM) , Madrid 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