{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T15:38:13Z","timestamp":1786117093896,"version":"build-2736575974"},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T00:00:00Z","timestamp":1753747200000},"content-version":"vor","delay-in-days":29,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Jamestown Canyon virus (JCV) is an emerging arboviral pathogen transmitted by mosquitoes in the United States and Canada. It is associated with neuroinvasive diseases and a wide spectrum of clinical presentations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective chart review was conducted at the Mayo Clinic Health System in Northwest Wisconsin from January 2018 to December 2024, analyzing data from 12 hospitalized patients diagnosed with JCV infection. This study aimed to characterize the clinical, laboratory, imaging, and outcome profiles of the disease. The cohort included individuals aged 19 to 75 years, predominantly male (75%), with all patients reporting outdoor activity and 75% being pet owners.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Only 27% of the patients recalled a mosquito bite. Among the cohort, 2 patients acquired an infection during the first trimester of pregnancy and subsequently delivered healthy infants. Coinfections with Borrelia burgdorferi were found in 33% of cases, while 16.7% of cases were seropositive to La Crosse virus. Magnetic resonance imaging of the brain was obtained in 5 patients and was nonspecific. Cerebrospinal fluid analysis demonstrated lymphocytic or monocytic pleocytosis in all cases where the test was performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>All patients experienced clinical improvement, with only 1 developing lingering neurological symptoms in the form of brain fog. This study highlights the clinical heterogeneity of JCV infections and underscores the importance of including JCV in the differential diagnosis for patients residing in or traveling from endemic areas.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ofid\/ofaf360","type":"journal-article","created":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T07:57:49Z","timestamp":1750319869000},"source":"Crossref","is-referenced-by-count":3,"title":["Clinical Characteristics and Outcome of Jamestown Canyon Virus Infection in Hospitalized Wisconsin Patients"],"prefix":"10.1093","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5312-8812","authenticated-orcid":false,"given":"Igor","family":"Dumic","sequence":"first","affiliation":[{"name":"Department of Hospital Medicine, Mayo Clinic Health System , Eau Claire, Wisconsin ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3012-4560","authenticated-orcid":false,"given":"Charles W","family":"Nordstrom","sequence":"additional","affiliation":[{"name":"Department of Hospital Medicine, Mayo Clinic Health System , Eau Claire, Wisconsin ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-2485-0820","authenticated-orcid":false,"given":"Janki","family":"Patel","sequence":"additional","affiliation":[{"name":"Mayo Clinic Health System , Eau Claire, Wisconsin ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6634-6272","authenticated-orcid":false,"given":"F N U","family":"Shweta","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease, Mayo Clinic Health System , Eau Claire, Wisconsin ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larry","family":"Lutwick","sequence":"additional","affiliation":[{"name":"Department of Medicine, Mayo Clinic College of Medicine , Rochester, Minnesota ,","place":["USA"]},{"name":"Program for Monitoring Emerging Infectious , Boston, Massachusetts ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,7,29]]},"reference":[{"key":"2026080609114908500_ofaf360-B1","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1177\/19418744211005948","article-title":"An overview of Jamestown Canyon virus disease","volume":"11","author":"Coleman","year":"2021","journal-title":"Neurohospitalist"},{"key":"2026080609114908500_ofaf360-B2","doi-asserted-by":"crossref","first-page":"874","DOI":"10.3201\/eid3005.221258","article-title":"Case series of Jamestown Canyon virus infections with neurologic outcomes, Canada, 2011\u20132016","volume":"30","author":"Meier-Stephenson","year":"2024","journal-title":"Emerg Infect Dis"},{"key":"2026080609114908500_ofaf360-B3","doi-asserted-by":"crossref","first-page":"2330","DOI":"10.3201\/eid2811.212382","article-title":"Jamestown Canyon virus in collected mosquitoes, Maine, United States, 2017\u20132019","volume":"28","author":"Schneider","year":"2022","journal-title":"Emerg Infect Dis"},{"key":"2026080609114908500_ofaf360-B4","doi-asserted-by":"crossref","first-page":"116161","DOI":"10.1016\/j.diagmicrobio.2023.116161","article-title":"Background seropositivity to Jamestown Canyon virus can lead to diagnostic confusion","volume":"108","author":"Gnanaprakasam","year":"2024","journal-title":"Diagn Microbiol Infect Dis"},{"key":"2026080609114908500_ofaf360-B5","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1093\/jme\/tjad069","article-title":"Jamestown Canyon virus comes into view: understanding the threat from an underrecognized arbovirus","volume":"60","author":"Shepard","year":"2023","journal-title":"J Med Entomol"},{"key":"2026080609114908500_ofaf360-B6","doi-asserted-by":"crossref","first-page":"384","DOI":"10.4269\/ajtmh.15-0196","article-title":"Jamestown Canyon virus disease in the United States-2000\u20132013","volume":"93","author":"Pastula","year":"2015","journal-title":"Am J Trop Med Hyg"},{"key":"2026080609114908500_ofaf360-B7","doi-asserted-by":"crossref","first-page":"238","DOI":"10.3201\/eid2701.203448","article-title":"Fatal case of chronic Jamestown Canyon virus encephalitis diagnosed by metagenomic sequencing in patient receiving rituximab","volume":"27","author":"Solomon","year":"2021","journal-title":"Emerg Infect Dis"},{"key":"2026080609114908500_ofaf360-B8","doi-asserted-by":"crossref","first-page":"e00966","DOI":"10.1016\/j.idcr.2020.e00966","article-title":"Encephalitis with coinfection by Jamestown Canyon virus (JCV) and varicella zoster virus 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from Wisconsin, USA, 2018\u20132019","volume":"10","author":"Farquhar","year":"2022","journal-title":"Front Public Health"},{"key":"2026080609114908500_ofaf360-B12","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1001\/jamaneurol.2018.0132","article-title":"Fatal powassan encephalitis (deer tick virus, lineage II) in a patient with fever and orchitis receiving rituximab","volume":"75","author":"Solomon","year":"2018","journal-title":"JAMA Neurol"},{"key":"2026080609114908500_ofaf360-B13","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1093\/cid\/cit458","article-title":"Case definitions, diagnostic algorithms, and priorities in encephalitis: consensus statement of the International Encephalitis Consortium","volume":"57","author":"Venkatesan","year":"2013","journal-title":"Clin Infect Dis"},{"key":"2026080609114908500_ofaf360-B14","doi-asserted-by":"crossref","first-page":"728","DOI":"10.3201\/eid2504.181016","article-title":"Differences in neuropathogenesis of 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