{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T10:12:41Z","timestamp":1779099161395,"version":"3.51.4"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T00:00:00Z","timestamp":1761177600000},"content-version":"vor","delay-in-days":24,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>People seeking humanitarian protections in the United States often have complex ecologic exposures during their migration, as in the Dari\u00e9n Jungle, a rainforest between Colombia and Panama. We characterized eosinophilia and select parasitic infections in this population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a cross-sectional study of clinical evaluations of unhoused people seeking humanitarian protection in Boston and New York City. Patients underwent laboratory testing based on clinician discretion. We extracted data regarding migration history and testing for eosinophilia (&amp;gt;500 cells\/\u03bcL), Strongyloides infection, and Chagas disease. We used \u03c72 testing to evaluate the association between exposure to the Dari\u00e9n Jungle and test results.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Our sample included 632 people (median age, 27 years; 55.0% female), primarily from Venezuela (32.0%), Ecuador (16.6%), Colombia (14.7%), and Haiti (13.3%). Of these, 411 people (65.0%) crossed the Dari\u00e9n Jungle. The median (IQR) duration in the Dari\u00e9n Jungle was 5 (4\u20137) days. We found that 71 people (11.2%) had eosinophilia. Of 438 people who completed testing for Strongyloides infection, 21 (4.8%) were positive, which occurred more frequently in people with eosinophilia (P = .006). Testing for Chagas was negative in all people. Children were more likely to have eosinophilia as compared with adults (odds ratio, 1.76; 95% CI, 1.04\u20132.95). There was no statistically significant association between crossing the Dari\u00e9n Jungle and eosinophilia (odds ratio, 1.13; 95% CI, .67\u20131.95).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Eosinophilia and Strongyloides infection are common among unhoused persons seeking humanitarian protections in the United States, particularly children. Clinicians should screen for these conditions and be vigilant for migration-related exposures.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ofid\/ofaf418","type":"journal-article","created":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T10:02:52Z","timestamp":1752746572000},"source":"Crossref","is-referenced-by-count":1,"title":["Eosinophilia and Select Parasitic Infections Among People Seeking Humanitarian Protections in the United States After Travel Through the Dari\u00e9n Jungle: A Multicenter Cross-sectional Study"],"prefix":"10.1093","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0779-921X","authenticated-orcid":false,"given":"Christian","family":"Olivo-Freites","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Ryan Health , New York City, New York ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9914-1599","authenticated-orcid":false,"given":"Luis C","family":"Ascanio","sequence":"additional","affiliation":[{"name":"Department of Pathology, Icahn School of Medicine at Mount Sinai , New York City, New York ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Paniz-Mondolfi","sequence":"additional","affiliation":[{"name":"Department of Pathology, Icahn School of Medicine at Mount Sinai , New York City, New York ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose Antonio","family":"Suarez","sequence":"additional","affiliation":[{"name":"Maestr\u00eda de Ciencias Biom\u00e9dicas, Universidad de Panam\u00e1 , Panam\u00e1 City, Panam\u00e1"},{"name":"Investigador SIN II Senacyt , Panam\u00e1 City, Panam\u00e1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angel N","family":"Desai","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, University of California Davis , Davis, California ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2402-451X","authenticated-orcid":false,"given":"Jacqueline T","family":"Chu","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Massachusetts General Hospital , Boston, Massachusetts ,","place":["USA"]},{"name":"Department of Medicine, Harvard Medical School , Boston, Massachusetts ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4558-0339","authenticated-orcid":false,"given":"Regina C","family":"LaRocque","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Massachusetts General Hospital , Boston, Massachusetts ,","place":["USA"]},{"name":"Department of Medicine, Harvard Medical School , Boston, Massachusetts ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3761-6154","authenticated-orcid":false,"given":"Amir M","family":"Mohareb","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Massachusetts General Hospital , Boston, Massachusetts ,","place":["USA"]},{"name":"Department of Medicine, Harvard Medical School , Boston, Massachusetts ,","place":["USA"]},{"name":"Center for Global Health, Massachusetts General Hospital , Boston, Massachusetts ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,10,10]]},"reference":[{"key":"2025102313582911000_ofaf418-B1"},{"key":"2025102313582911000_ofaf418-B2","author":"Ward"},{"key":"2025102313582911000_ofaf418-B3","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1093\/cid\/ciac697","article-title":"Climate change and the epidemiology of infectious diseases in the United 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