{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:30:45Z","timestamp":1787009445615,"version":"build-2736575974"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T00:00:00Z","timestamp":1754524800000},"content-version":"vor","delay-in-days":7,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Artesunate\u2013amodiaquine has been the first-line treatment for uncomplicated malaria in S\u00e3o Tom\u00e9 and Pr\u00edncipe since 2005, following many decades of chloroquine usage. We evaluated the recent dynamics in prevalence of the Plasmodium falciparum amodiaquine-resistance-associated pfmdr1 86Y\/Y184\/1246Y haplotype, by analyzing infections from the 2020\u20132022 period and comparing them with historical data. The results suggest that the introduction of artesunate\u2013amodiaquine led to a trajectory of single nucleotide polymorphism (SNP) successive accretion in a pre-existing environment of pfcrt 76T near fixation, leading to the emergence of a dominant 86Y\/Y184\/1246Y haplotype. Our data support increased vigilance of artesunate\u2013amodiaquine performance in S\u00e3o Tom\u00e9 and Pr\u00edncipe.<\/jats:p>","DOI":"10.1093\/ofid\/ofaf475","type":"journal-article","created":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T11:53:14Z","timestamp":1754567594000},"source":"Crossref","is-referenced-by-count":1,"title":["Trajectory of\n                    <i>Plasmodium falciparum<\/i>\n                    Molecular Markers of Amodiaquine Resistance in S\u00e3o Tom\u00e9 and Pr\u00edncipe"],"prefix":"10.1093","volume":"12","author":[{"given":"Samora","family":"T\u00e9","sequence":"first","affiliation":[{"name":"Science and Community Support Service (SACC), Institute of Hygiene and Tropical Medicine, Nova University of Lisbon , Lisbon ,","place":["Portugal"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edvaldo","family":"Das Neves","sequence":"additional","affiliation":[{"name":"Global Health and Tropical Medicine, GHTM, Associate Laboratory in Translation and Innovation Towards Global Health, LA-REAL, Instituto de Higiene e Medicina Tropical, IHMT, Universidade NOVA de Lisboa, UNL , Rua da Junqueira 100, 1349-008 Lisboa ,","place":["Portugal"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2905-1317","authenticated-orcid":false,"given":"Ane","family":"Pellicer","sequence":"additional","affiliation":[{"name":"Science and Community Support Service (SACC), Institute of Hygiene and Tropical Medicine, Nova University of Lisbon , Lisbon ,","place":["Portugal"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2376-3820","authenticated-orcid":false,"given":"Ioanna","family":"Broumou","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Solna, Karolinska Institutet , Stockholm ,","place":["Sweden"]},{"name":"Department of Infectious Diseases, Karolinska University Hospital , Stockholm ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4727-4570","authenticated-orcid":false,"given":"Julia","family":"Zerebinski","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Solna, Karolinska Institutet , Stockholm ,","place":["Sweden"]},{"name":"Department of Infectious Diseases, Karolinska University Hospital , Stockholm ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Santos-Reis","sequence":"additional","affiliation":[{"name":"Science and Community Support Service (SACC), Institute of Hygiene and Tropical Medicine, Nova University of Lisbon , Lisbon ,","place":["Portugal"]},{"name":"Global Health and Tropical Medicine, GHTM, Associate Laboratory in Translation and Innovation Towards Global Health, LA-REAL, Instituto de Higiene e Medicina Tropical, IHMT, Universidade NOVA de Lisboa, UNL , Rua da Junqueira 100, 1349-008 Lisboa ,","place":["Portugal"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6874-9427","authenticated-orcid":false,"given":"Ta\u00eds","family":"N\u00f3brega de Sousa","sequence":"additional","affiliation":[{"name":"Host Microbe Division, Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet , Stockholm ,","place":["Sweden"]},{"name":"Molecular Biology and Malaria Immunology Research Group, Instituto Ren\u00e9 Rachou, Funda\u00e7\u00e3o Oswaldo Cruz (FIOCRUZ) , Belo Horizonte ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7583-282X","authenticated-orcid":false,"given":"Anna","family":"F\u00e4rnert","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Solna, Karolinska Institutet , Stockholm ,","place":["Sweden"]},{"name":"Department of Infectious Diseases, Karolinska University Hospital , Stockholm ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adalberto","family":"Santos","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Sa\u00fade P\u00fablica, Minist\u00e9rio da Sa\u00fade , S\u00e3o Tom\u00e9, S\u00e3o Tom\u00e9 and Pr\u00edncipe"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria de Jesus","family":"Santos","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Sa\u00fade P\u00fablica, Minist\u00e9rio da Sa\u00fade , S\u00e3o Tom\u00e9, S\u00e3o Tom\u00e9 and Pr\u00edncipe"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6107-9379","authenticated-orcid":false,"given":"Jose Pedro","family":"Gil","sequence":"additional","affiliation":[{"name":"Global Health and Tropical Medicine, GHTM, Associate Laboratory in Translation and Innovation Towards Global Health, LA-REAL, Instituto de Higiene e Medicina Tropical, IHMT, Universidade NOVA de Lisboa, UNL , Rua da Junqueira 100, 1349-008 Lisboa ,","place":["Portugal"]},{"name":"Host Microbe Division, Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet , Stockholm ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dinora","family":"Lopes","sequence":"additional","affiliation":[{"name":"Science and Community Support Service (SACC), Institute of Hygiene and Tropical Medicine, Nova University of Lisbon , Lisbon ,","place":["Portugal"]},{"name":"Global Health and Tropical Medicine, GHTM, Associate Laboratory in Translation and Innovation Towards Global Health, LA-REAL, Instituto de Higiene e Medicina Tropical, IHMT, Universidade NOVA de Lisboa, UNL , Rua da Junqueira 100, 1349-008 Lisboa ,","place":["Portugal"]},{"name":"Tropical Medicine Unit, Institute of Hygiene and Tropical Medicine, Nova University of Lisbon , Lisbon 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