{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T23:51:56Z","timestamp":1778629916576,"version":"3.51.4"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T00:00:00Z","timestamp":1759190400000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Fever can be described as a coordinated rise in temperature in response to infectious and noninfectious causes, which varies with the anatomical site. This adaptive heat shock response has been conserved for millions of years in vertebrates. Elevated temperature stimulates and optimizes innate and adaptive immune responses. In addition, most microorganisms have shown thermal stress\u2013related growth inhibition, and in vitro data indicate that \u03b2-lactam antibiotics in particular appear to have significantly improved susceptibility profiles in the presence of fever-range temperatures. Despite these favorable effects of fever, many physicians consider fever a harmful event that should be treated without discrimination of the underlying cause. Observational studies have indicated that attempts to lower the temperature in patients with sepsis are associated with increased mortality. This article aims to summarize the most relevant results of the existing clinical data and provide the clinician with guidance on how to manage fever in patients with sepsis.<\/jats:p>","DOI":"10.1093\/ofid\/ofaf608","type":"journal-article","created":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T11:44:25Z","timestamp":1759059865000},"source":"Crossref","is-referenced-by-count":1,"title":["Fever in Sepsis Revisited: Is a Little Heat What We Need?"],"prefix":"10.1093","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3961-5881","authenticated-orcid":false,"given":"Alwin","family":"Tilanus","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, Infectious Disease Specialist\/Biological Health Scientist, Vida Medical IPS , Bogot\u00e1 ,","place":["Colombia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5492-3455","authenticated-orcid":false,"given":"Wilmer","family":"Villamil","sequence":"additional","affiliation":[{"name":"Research Center Ciencias de la Vida, Department of Infectious Diseases and Tropical Medicine, Universidad Simon Bolivar , Barranquilla ,","place":["Colombia"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,9,30]]},"reference":[{"issue":"Suppl1","key":"2025102314035476700_ofaf608-B1","doi-asserted-by":"crossref","first-page":"S54","DOI":"10.1016\/j.ctim.2011.08.002","article-title":"Perspective on fever: the basic science and conventional medicine","volume":"21","author":"Cannon","year":"2013","journal-title":"Complement Ther Med"},{"key":"2025102314035476700_ofaf608-B2","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.amjmed.2022.10.018","article-title":"The \u2018body temperature\u2019 myth","volume":"136","author":"Mackowiak","year":"2023","journal-title":"Am J Med"},{"key":"2025102314035476700_ofaf608-B3","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/nri3843","article-title":"Fever and the thermal regulation of immunity: the immune system feels the heat","volume":"15","author":"Evans","year":"2015","journal-title":"Nat Rev Immunol"},{"key":"2025102314035476700_ofaf608-B4","doi-asserted-by":"crossref","first-page":"ofaa132","DOI":"10.1093\/ofid\/ofaa132","article-title":"Fever and fever of unknown origin: review, recent advances, and lingering dogma","volume":"7","author":"Wright","year":"2020","journal-title":"Open Forum Infect Dis"},{"key":"2025102314035476700_ofaf608-B5","doi-asserted-by":"crossref","first-page":"92","DOI":"10.7453\/gahmj.2012.1.1.016","article-title":"Fever in cancer treatment: Coley's therapy and epidemiologic observations","volume":"1","author":"Kienle","year":"2012","journal-title":"Glob Adv Health Med"},{"key":"2025102314035476700_ofaf608-B6","first-page":"311","article-title":"Temperature characteristics and Arrhenius plots for nominal psychrophiles, mesophiles and thermophiles","volume":"121","author":"Mohr","year":"1980","journal-title":"J Gen Microbiol"},{"key":"2025102314035476700_ofaf608-B7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/jb.149.1.1-5.1982","article-title":"Relationship between temperature and growth rate of bacterial cultures","volume":"149","author":"Ratkowsky","year":"1982","journal-title":"J Bacteriol"},{"key":"2025102314035476700_ofaf608-B8","doi-asserted-by":"crossref","first-page":"e0153343","DOI":"10.1371\/journal.pone.0153343","article-title":"The biokinetic spectrum for temperature","volume":"11","author":"Corkrey","year":"2016","journal-title":"PLoS One"},{"issue":"Suppl 5","key":"2025102314035476700_ofaf608-B9","doi-asserted-by":"crossref","first-page":"S185","DOI":"10.1086\/317511","article-title":"Physiological rationale for suppression of fever","volume":"31","author":"Mackowiak","year":"2000","journal-title":"Clin Infect Dis"},{"key":"2025102314035476700_ofaf608-B10","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1186\/cc10097","article-title":"Fever in septic ICU patients\u2014friend or foe?","volume":"15","author":"Launey","year":"2011","journal-title":"Crit Care"},{"key":"2025102314035476700_ofaf608-B11","doi-asserted-by":"crossref","first-page":"e20103852","DOI":"10.1542\/peds.2010-3852","article-title":"Fever and antipyretic use in children","volume":"127","author":"Sullivan","year":"2011","journal-title":"Pediatrics"},{"key":"2025102314035476700_ofaf608-B12","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1186\/cc13773","article-title":"Fever management in intensive care patients with infections","volume":"18","author":"Young","year":"2014","journal-title":"Crit Care"},{"key":"2025102314035476700_ofaf608-B13","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1186\/s13054-016-1467-2","article-title":"Should we treat pyrexia? 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