{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T13:31:58Z","timestamp":1764941518102,"version":"3.46.0"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T00:00:00Z","timestamp":1764892800000},"content-version":"vor","delay-in-days":9,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000005","name":"Department of Defense","doi-asserted-by":"publisher","award":["W81XWH-20-1-0508","HT94252410378"],"award-info":[{"award-number":["W81XWH-20-1-0508","HT94252410378"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Biomedical Innovations Award"},{"name":"Stony Brook Foundation"},{"name":"Assistant Secretary of Defense for Health Affairs"},{"name":"Tick-Borne Disease Research Program","award":["W81XWH-22-1-0947"],"award-info":[{"award-number":["W81XWH-22-1-0947"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Babesiosis, caused by the parasitic blood-borne piroplasm Babesia microti, is emerging in the Northern hemisphere. We aimed to study long-term symptoms of patients with B microti infection in New York.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A prospective longitudinal cohort study of human babesiosis was conducted at Stony Brook University Hospital. Inclusion criteria were age \u226518 years with positive blood smear for Babesia spp. Symptoms were assessed in patients at presentation and at 1, 6, and 12 months by 3 validated surveys: a visual analog scale, a quality of life (QOL) questionnaire, and the 36-Item Short Form Survey (SF-36).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In total, 38 patients with acute B microti infection (26% female; age range, 54\u201373 years) were enrolled from 2020 to 2022. Compared with baseline, the visual analog scale total symptom scores (with high scores representing worse status) significantly decreased at 6-month follow-up for the immunocompetent (n = 9; P &amp;lt; .001) and immunocompromised groups (n = 6; P &amp;lt; .001). Scores remained significantly higher in the immunocompromised group (ratio, 2.6; P = .045). At 1-year follow-up, the scores in the 2 groups tended to be similar (ratio, 0.9; P = .82). Within QOL concept scores (with low scores representing worse status), physical functioning significantly increased after 6 months of follow-up in both cohorts (immunocompetent, n = 10 [P = .004]; immunocompromised, n = 5 [P = .008]) but was still significantly lower in the immunocompromised group at that time (ratio, 0.7; P &amp;lt; .001). By the 12-month follow-up, physical functioning scores in the 2 groups appeared to converge, though the difference remained borderline significant (ratio, 0.9; P = .06).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The time to convalescence was similar among patients with babesiosis, though immunocompromised patients tended to have more prolonged symptoms and worsened QOL after babesiosis at 1-year follow-up, compared with immunocompetent patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ofid\/ofaf668","type":"journal-article","created":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T13:41:24Z","timestamp":1761745284000},"source":"Crossref","is-referenced-by-count":0,"title":["A Prospective Cohort Longitudinal Study of Human Acute Babesiosis: Quality of Life and Severity of Symptoms Through 1-Year Follow-up"],"prefix":"10.1093","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-1086-7564","authenticated-orcid":false,"given":"Rudline","family":"Zamor","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Stony Brook University , Stony Brook, New York ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyue","family":"Zhang","sequence":"additional","affiliation":[{"name":"Biostatistical Consulting Core, School of Medicine, Stony Brook University (State University of New York) , Stony Brook, New York ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pooja","family":"Lamba","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Stony Brook University , Stony Brook, New York ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brigitte","family":"Maczaj","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Stony Brook University , Stony Brook, New York ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7516-7225","authenticated-orcid":false,"given":"Sarath G","family":"Nath","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Stony Brook University , Stony Brook, New York ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aikaterini","family":"Papamanoli","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Stony Brook University , Stony Brook, New York ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4462-3870","authenticated-orcid":false,"given":"Bennadette","family":"Maramara","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Stony Brook University , Stony Brook, New York ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Lum","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Stony Brook University , Stony Brook, New York ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atul","family":"Pradhan","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Stony Brook University , Stony Brook, New York ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4350-1215","authenticated-orcid":false,"given":"Christine","family":"Li","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Stony Brook University , Stony Brook, New York ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victoria","family":"Bateman","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Stony Brook University , Stony Brook, New York ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3469-5931","authenticated-orcid":false,"given":"Jie","family":"Yang","sequence":"additional","affiliation":[{"name":"Biostatistical Consulting Core, School of Medicine, Stony Brook University (State University of New York) , Stony Brook, New York ,","place":["USA"]},{"name":"Department of Family, Population and Preventive Medicine, Stony Brook University , Stony Brook, New York ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4952-7041","authenticated-orcid":false,"given":"Charles K","family":"Vorkas","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Stony Brook University , Stony Brook, New York ,","place":["USA"]},{"name":"Department of Microbiology and Immunology, Stony Brook University , Stony Brook, New York ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8794-2441","authenticated-orcid":false,"given":"Eric D","family":"Spitzer","sequence":"additional","affiliation":[{"name":"Department of Pathology, Stony Brook University , Stony Brook, New York ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dana G","family":"Mordue","sequence":"additional","affiliation":[{"name":"Department of Pathology, Microbiology, and Immunology, New York Medical College , Valhalla, New York ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3589-0432","authenticated-orcid":false,"given":"Luis A","family":"Marcos","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Stony Brook University , Stony Brook, New York ,","place":["USA"]},{"name":"Department of Microbiology and Immunology, Stony Brook University , Stony Brook, New York ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,12,5]]},"reference":[{"key":"2025120508011253600_ofaf668-B1","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.3201\/eid2010.130938","article-title":"Human babesiosis, Maine, USA, 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