{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T10:01:13Z","timestamp":1792144873709,"version":"4.4.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T00:00:00Z","timestamp":1762387200000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>More data is required to contextualize disease burden attributable to respiratory-viral-infections (RVIs) in hematology\/oncology patients; including vaccine-preventable RVIs (eg. influenza, respiratory-syncytial-virus[RSV]) and other RVIs for which vaccines\/therapeutics are not presently available (eg. metapneumovirus[HMPV]\/parainfluenza [HPIV]).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective cohort study of all adult RVI hospitalizations diagnosed on multiplex PCR testing from 2018-2024 in a large Singaporean cancer center. Severity was defined as a composite of multiple individual severe events (oxygen usage; ICU\/HD admission; all-cause mortality). Patients were followed-up from admission till discharge\/up to 1-month. Comparative severity of RSV and other non-vaccine-preventable RVIs (eg. HMPV\/HPIV), versus seasonal influenza, was evaluated using multivariate logistic regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>1,823 RVI hospitalizations were included; 24.0% had influenza (N=437); 12.9% had RSV (N=235), and the remainder had other RVIs (eg. HMPV: N=128; HPIV: N=204). A third (29.4%, 536\/1823) had severe infection (required oxygen\/ICU\/mortality events); 26.9% (491\/1823) required oxygen, 6.9% (126\/1823) required ICU\/HD and 14.8% (269\/1823) died. Other RVIs (eg. RSV\/HMPV\/adenovirus) were more severe overall, versus influenza (RSV: adjusted-odds-ratio, aOR=1.94[95%CI=1.33-2.83]; HMPV: aOR=1.77[95%CI=1.12-2.80]; adenovirus: aOR=2.19[95%CI=1.33-3.63]). RSV hospitalizations had increased odds for ICU\/HD admission (aOR=2.41[95%CI=1.22-4.77]) and all-cause mortality at 1 month (aOR=2.42 [95%CI=1.42-4.12]) versus seasonal influenza. Older age (aOR=1.30[95%CI=1.03-1.64]), comorbidities (aOR=1.50[95%CI=1.18-1.90]), co-infections (aOR=1.70[95%CI=1.21-2.38]) and nosocomial transmission (aOR=1.53[95%CI=1.20-1.94]) were associated with greater severity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>RSV hospitalizations were more severe than influenza in cancer patients; but higher odds of severity were also observed for other RVIs (HMPV\/adenovirus), underlining the need for new vaccines\/therapeutics. Given significant morbidity\/mortality of nosocomial RVI, infection-prevention is crucial in preventing outbreaks in this immunocompromised population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ofid\/ofaf682","type":"journal-article","created":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T07:22:03Z","timestamp":1762672923000},"source":"Crossref","is-referenced-by-count":7,"title":["Severity of respiratory-syncytial-virus and other respiratory viruses versus seasonal influenza amongst hospitalized cancer patients"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6428-9999","authenticated-orcid":false,"given":"Liang En","family":"Wee","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, Singapore General Hospital ,","place":["Singapore"]},{"name":"Department of Infection Prevention and Epidemiology, Singapore General Hospital ,","place":["Singapore"]},{"name":"Duke-NUS Medical School ,","place":["Singapore"]},{"name":"Lee Kong Chian School of Medicine, Nanyang Technological University ,","place":["Singapore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6474-7295","authenticated-orcid":false,"given":"Leicester Shawn","family":"Alcantara","sequence":"additional","affiliation":[{"name":"Department of Infection Prevention and Epidemiology, Singapore General Hospital ,","place":["Singapore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"May Kyawt","family":"Aung","sequence":"additional","affiliation":[{"name":"Department of Infection Prevention and Epidemiology, Singapore General Hospital ,","place":["Singapore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shalvi","family":"Arora","sequence":"additional","affiliation":[{"name":"Department of Infection Prevention and Epidemiology, Singapore General Hospital ,","place":["Singapore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Xiang Ying","family":"Sim","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Singapore General Hospital ,","place":["Singapore"]},{"name":"Department of Infection Prevention and Epidemiology, Singapore General Hospital ,","place":["Singapore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Dong","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Tan Tock Seng Hospital ,","place":["Singapore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4931-9685","authenticated-orcid":false,"given":"Zachary Allen","family":"Vincent","sequence":"additional","affiliation":[{"name":"Lee Kong Chian School of Medicine, Nanyang Technological University ,","place":["Singapore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8778-297X","authenticated-orcid":false,"given":"Veeramani","family":"Srivathsan","sequence":"additional","affiliation":[{"name":"Lee Kong Chian School of Medicine, Nanyang Technological University ,","place":["Singapore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tertius Tansloan","family":"Tuy","sequence":"additional","affiliation":[{"name":"Duke-NUS Medical School ,","place":["Singapore"]},{"name":"Department of Haematology, Singapore General Hospital ,","place":["Singapore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin Yeu","family":"Ong","sequence":"additional","affiliation":[{"name":"Duke-NUS Medical School ,","place":["Singapore"]},{"name":"Department of Haematology, Singapore General Hospital ,","place":["Singapore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei Chong","family":"Tan","sequence":"additional","affiliation":[{"name":"Duke-NUS Medical School ,","place":["Singapore"]},{"name":"Division of Medical Oncology, National Cancer Centre ,","place":["Singapore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iain Beehuat","family":"Tan","sequence":"additional","affiliation":[{"name":"Duke-NUS Medical School ,","place":["Singapore"]},{"name":"Division of Medical Oncology, National Cancer Centre ,","place":["Singapore"]},{"name":"Genome Institute of Singapore"},{"name":"Saw Swee Hock School of Public Health, National University of Singapore ,","place":["Singapore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Limin","family":"Wijaya","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Singapore General Hospital ,","place":["Singapore"]},{"name":"Duke-NUS Medical School ,","place":["Singapore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Indumathi","family":"Venkatachalam","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Singapore General Hospital ,","place":["Singapore"]},{"name":"Department of Infection Prevention and Epidemiology, Singapore General Hospital ,","place":["Singapore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelvin Bryan","family":"Tan","sequence":"additional","affiliation":[{"name":"Duke-NUS Medical School ,","place":["Singapore"]},{"name":"Lee Kong Chian School of Medicine, Nanyang Technological University ,","place":["Singapore"]},{"name":"Saw Swee Hock School of Public Health, National University of Singapore ,","place":["Singapore"]},{"name":"Yong Loo Lin School of Medicine, National University of Singapore ,","place":["Singapore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0213-5470","authenticated-orcid":false,"given":"Benjamin W","family":"Teh","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Peter MacCallum Cancer Centre , Melbourne, Victoria ,","place":["Australia"]},{"name":"Sir Peter MacCallum Department of Oncology, University of Melbourne , Parkville, Victoria ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1458-9456","authenticated-orcid":false,"given":"Ban Hock","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Singapore General Hospital ,","place":["Singapore"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,11,6]]},"container-title":["Open Forum Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ofid\/advance-article-pdf\/doi\/10.1093\/ofid\/ofaf682\/65237619\/ofaf682.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ofid\/advance-article-pdf\/doi\/10.1093\/ofid\/ofaf682\/65237619\/ofaf682.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T07:22:04Z","timestamp":1762672924000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ofid\/advance-article\/doi\/10.1093\/ofid\/ofaf682\/8316235"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,6]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1093\/ofid\/ofaf682","relation":{},"ISSN":["2328-8957"],"issn-type":[{"value":"2328-8957","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,6]]},"article-number":"ofaf682"}}