{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T07:23:10Z","timestamp":1765610590892,"version":"3.46.0"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T00:00:00Z","timestamp":1762905600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Juan Rod\u00e9s","award":["JR24\/00034"],"award-info":[{"award-number":["JR24\/00034"]}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Spanish Ministry of Science"},{"name":"Innovation and Universities"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Bruton tyrosine kinase inhibitors (BTKis) have been associated with an increased risk of invasive fungal disease, with skin and soft tissue mucormycosis accounting for a minority of cases. We present a 72-year-old patient with chronic lymphocytic leukemia who developed necrotizing fasciitis and myositis due to Lichtheimia spp after 4 months of therapy with the second-generation BTKi zanubrutinib, with a fatal outcome despite aggressive treatment. Our literature review identified 7 additional cases of BTKi-associated skin and soft tissue mucormycosis, revealing an all-cause mortality rate of 37.5%. Two-thirds of the patients had a previous trauma or skin lesion.<\/jats:p>","DOI":"10.1093\/ofid\/ofaf691","type":"journal-article","created":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T13:04:38Z","timestamp":1762520678000},"source":"Crossref","is-referenced-by-count":1,"title":["Skin and Soft Tissue Mucormycosis in Patients Receiving Bruton Tyrosine Kinase Inhibitors: Case Report and Literature Review"],"prefix":"10.1093","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-1497-8770","authenticated-orcid":false,"given":"Eduardo","family":"Aparicio-Minguij\u00f3n","sequence":"first","affiliation":[{"name":"Unit of Infectious Diseases, Hospital Universitario \u201c12 de Octubre,\u201d Instituto de Investigaci\u00f3n Sanitaria Hospital \u201c12 de Octubre,\u201d \u00a0 Madrid ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0090-6673","authenticated-orcid":false,"given":"Nieves","family":"L\u00f3pez-Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Department of Hematology, Hospital Universitario \u201c12 de Octubre,\u201d Instituto de Investigaci\u00f3n Sanitaria Hospital \u201c12 de Octubre,\u201d \u00a0 Madrid ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2682-0819","authenticated-orcid":false,"given":"Jorge","family":"Bo\u00e1n","sequence":"additional","affiliation":[{"name":"Unit of Infectious Diseases, Hospital Universitario \u201c12 de Octubre,\u201d Instituto de Investigaci\u00f3n Sanitaria Hospital \u201c12 de Octubre,\u201d \u00a0 Madrid ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1578-2909","authenticated-orcid":false,"given":"Mar\u00eda Asunci\u00f3n","family":"P\u00e9rez-Jacoiste As\u00edn","sequence":"additional","affiliation":[{"name":"Unit of Infectious Diseases, Hospital Universitario \u201c12 de Octubre,\u201d Instituto de Investigaci\u00f3n Sanitaria Hospital \u201c12 de Octubre,\u201d \u00a0 Madrid ,","place":["Spain"]},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Infecciosas, Instituto de Salud Carlos III , Madrid ,","place":["Spain"]},{"name":"Department of Medicine, School of Medicine, Universidad Complutense , Madrid ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3904-1101","authenticated-orcid":false,"given":"Javier","family":"de la Serna","sequence":"additional","affiliation":[{"name":"Department of Hematology, Hospital Universitario \u201c12 de Octubre,\u201d Instituto de Investigaci\u00f3n Sanitaria Hospital \u201c12 de Octubre,\u201d \u00a0 Madrid ,","place":["Spain"]},{"name":"Department of Medicine, School of Medicine, Universidad Complutense , Madrid ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6426-6279","authenticated-orcid":false,"given":"Ana","family":"P\u00e9rez-Ayala","sequence":"additional","affiliation":[{"name":"Department of Medicine, School of Medicine, Universidad Complutense , Madrid ,","place":["Spain"]},{"name":"Department of Microbiology, Hospital Universitario \u201c12 de Octubre,\u201d Instituto de Investigaci\u00f3n Sanitaria Hospital \u201c12 de Octubre,\u201d \u00a0 Madrid ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Bel\u00e9n","family":"Enguita","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hospital Universitario \u201c12 de Octubre,\u201d Instituto de Investigaci\u00f3n Sanitaria Hospital \u201c12 de Octubre,\u201d \u00a0 Madrid ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2150-5748","authenticated-orcid":false,"given":"Isabel","family":"Rodr\u00edguez-Goncer","sequence":"additional","affiliation":[{"name":"Unit of Infectious Diseases, Hospital Universitario \u201c12 de Octubre,\u201d Instituto de Investigaci\u00f3n Sanitaria Hospital \u201c12 de Octubre,\u201d \u00a0 Madrid ,","place":["Spain"]},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Infecciosas, Instituto de Salud Carlos III , Madrid ,","place":["Spain"]},{"name":"Department of Medicine, School of Medicine, Universidad Complutense , Madrid 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