{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:09:58Z","timestamp":1791230998195,"version":"4.1.0"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T00:00:00Z","timestamp":1763510400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Severe fever with thrombocytopenia syndrome (SFTS) is a viral hemorrhagic fever caused by the SFTS virus (SFTSV), a tick-borne Phlebovirus. This study investigates the association between viral load and cytokine levels in patients with SFTS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Viral RNA was isolated from plasma collected in EDTA and quantified by real-time reverse transcription-polymerase chain reaction (RT-PCR). Cytokines in the sera of SFTS patients were measured using cytometric bead array (CBA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Viral loads ranged from 2.3 \u00d7 103 copies\/mL to 7.9 \u00d7 1011 copies\/mL. Of the 46 patients, 10 (21.7%) died during treatment. Viral loads were \u22651 \u00d7 108 copies\/mL in the patients who died. The concentrations of G-CSF, IFN-\u03b1, IFN-\u03b3, IL-1\u03b2, IL-6, IL-10, MCP-1, and IP-10 were higher in patients with high viral loads. The levels of IFN-\u03b1, IFN-\u03b3, IL-6, MCP-1, and IP-10 positively correlated with SFTSV viral load.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>SFTSV RNA load was significantly correlated with the concentration of IFN-\u03b1, as well as other cytokines (IFN-\u03b3, IL-6, MIP-1\u03b1, and IP-10).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ofid\/ofaf712","type":"journal-article","created":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T12:25:28Z","timestamp":1763382328000},"source":"Crossref","is-referenced-by-count":6,"title":["Relationship Between Cytokine Level and Viral Load in Severe Fever with Thrombocytopenia Syndrome"],"prefix":"10.1093","volume":"12","author":[{"given":"Lili","family":"Guo","sequence":"first","affiliation":[{"name":"Infection Control Department, The Second Hospital of Nanjing, Affiliated to Nanjing University of Chinese Medicine , Nanjing, Jiangsu ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6079-7208","authenticated-orcid":false,"given":"Hao","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, The Second Hospital of Nanjing, Affiliated to Nanjing University of Chinese Medicine , Nanjing, Jiangsu ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,11,19]]},"reference":[{"key":"2026030710520661100_ofaf712-B1","doi-asserted-by":"crossref","first-page":"3689","DOI":"10.2169\/internalmedicine.55.7540","article-title":"Severe fever with thrombocytopenia syndrome","volume":"55","author":"Taniguchi","year":"2016","journal-title":"Intern Med"},{"key":"2026030710520661100_ofaf712-B2","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1093\/cid\/cit100","article-title":"Epidemiologic features of severe fever 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