{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T20:58:02Z","timestamp":1788814682456,"version":"build-2803163510"},"reference-count":65,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T00:00:00Z","timestamp":1766448000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100020492","name":"Dixon Translational Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020492","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016864","name":"Buffett Institute at Northwestern University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016864","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012264","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012264","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"NIAID","doi-asserted-by":"publisher","award":["K23 AI139337"],"award-info":[{"award-number":["K23 AI139337"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"NIAID","doi-asserted-by":"publisher","award":["K08AI123524"],"award-info":[{"award-number":["K08AI123524"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,12,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Enterobacterales with ampicillin (AmpR-E) and ceftriaxone resistance (CefR-E) are globally prevalent. Perinatal transmission and infections with CefR-E strains are associated with higher mortality, morbidity, and health care costs. This study estimated the rate of gut colonization of AmpR-E and CefR-E in healthy birthing parent\u2013infant dyads in Chicago and investigated the genetic characteristics of CefR-E.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Pregnant persons anticipating vaginal birth at 2 Chicago-area hospitals were enrolled. Pregnancy and birth history were obtained. Maternal vaginal and rectal swabs and infant stool samples were collected and screened for resistance. CefR-E isolates underwent whole-genome sequencing analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Birthing parent\u2013infant dyads were enrolled and 293 parent, and 261 infant samples were collected (July 2020\u2013January 2023). After exclusionary criteria, parental AmpR-E colonization was 91% (216\/238), and infant AmpR-E colonization was 76% (158\/208). The rate of parental and infant CefR-E colonization was 12% (28\/238) and 7% (15\/208), respectively. Estimated perinatal transmission of CefR-E was 17% (4\/24). Race was the only clinical variable significantly associated with parental CefR-E colonization (higher Asian, decreased White race). Birthing parent age and type of infant nutrition (breastmilk) were significantly associated with decreased infant AmpR-E colonization (P &amp;lt; .05). Whole-genome sequencing of the CefR-E isolates showed that 38% (22\/58) were E. coli.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study demonstrates that a sizable percentage of healthy pregnant persons are colonized with AmpR-E and CefR-E in the United States, a higher burden than previously reported for high-income countries. Enterobacterales appear adept in perinatal transmission, with a significant proportion of infants born to colonized pregnant persons harboring CefR-E in the first week of life.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ofid\/ofaf769","type":"journal-article","created":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T12:50:49Z","timestamp":1765889449000},"source":"Crossref","is-referenced-by-count":1,"title":["Maternal Colonization, Perinatal Exposure, and Neonatal Acquisition of Resistant Enterobacterales"],"prefix":"10.1093","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1070-5306","authenticated-orcid":false,"given":"Leena B","family":"Mithal","sequence":"first","affiliation":[{"name":"Ann and Robert H. Lurie Children's Hospital , Chicago, IL, USA"},{"name":"Feinberg School of Medicine, Northwestern University , Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alima","family":"Sajwani","sequence":"additional","affiliation":[{"name":"Ann and Robert H. Lurie Children's Hospital , Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abigail","family":"Aron","sequence":"additional","affiliation":[{"name":"Ann and Robert H. Lurie Children's Hospital , Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0312-6077","authenticated-orcid":false,"given":"Weitao","family":"Shuai","sequence":"additional","affiliation":[{"name":"Department of Civil and Environmental Engineering, Northwestern University , Evanston, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9414-7793","authenticated-orcid":false,"given":"Aspen","family":"Kremer","sequence":"additional","affiliation":[{"name":"Ann and Robert H. Lurie Children's Hospital , Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7921-9863","authenticated-orcid":false,"given":"Andrew D","family":"Watson","sequence":"additional","affiliation":[{"name":"Department of Civil and Environmental Engineering, Northwestern University , Evanston, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack T","family":"Sumner","sequence":"additional","affiliation":[{"name":"Department of Civil and Environmental Engineering, Northwestern University , Evanston, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria C Castro","family":"Manzano","sequence":"additional","affiliation":[{"name":"Department of Civil and Environmental Engineering, Northwestern University , Evanston, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6247-7979","authenticated-orcid":false,"given":"Grayson","family":"Donnelly","sequence":"additional","affiliation":[{"name":"Department of Civil and Environmental Engineering, Northwestern University , Evanston, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily S","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Obstetrics & Gynecology, Division of Maternal Fetal Medicine, Warren Alpert Medical School of Brown University , Providence, RI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel B","family":"Fisher","sequence":"additional","affiliation":[{"name":"Northwest Community Hospital, Arlington Heights , IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0966-2014","authenticated-orcid":false,"given":"Erica M","family":"Hartmann","sequence":"additional","affiliation":[{"name":"Feinberg School of Medicine, Northwestern University , Chicago, IL, USA"},{"name":"Department of Civil and Environmental Engineering, Northwestern University , Evanston, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7517-9274","authenticated-orcid":false,"given":"Mehreen","family":"Arshad","sequence":"additional","affiliation":[{"name":"Ann and Robert H. 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