{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:30:52Z","timestamp":1787009452898,"version":"build-2736575974"},"reference-count":51,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T00:00:00Z","timestamp":1766448000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000105","name":"Sanofi and York University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000105","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,12,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chlamydia trachomatis (CT) is a common sexually transmitted infection, yet its contribution to male infertility remains incompletely understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic review and meta-analysis of case-control studies were conducted following PRISMA guidelines. Literature from PubMed\/MEDLINE, Scopus, Cochrane, and Embase (2000 onward) was screened. Random-effects models were used in R, with subgroup analyses by geography, case definition, diagnostics, and matching criteria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Out of 2941 records, 26 case-control studies (11 706 participants) met inclusion criteria. Most studies used molecular diagnostics (n = 23). A significant association was found between CT infection and male infertility (odds ratio [OR] 3.68 [95% CI 2.24\u20136.02]), with substantial heterogeneity (I2 = 65%). Age-matched studies showed higher effect sizes (OR 6.77), and publication bias was detected (trimmed OR 2.75).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>While findings suggest that CT infection may impair male fertility, confounding, bias, and the lack of geographical representativeness limit inference. High-quality, large-scale prospective studies are needed to confirm causality and guide targeted interventions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ofid\/ofaf782","type":"journal-article","created":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T12:47:58Z","timestamp":1766234878000},"source":"Crossref","is-referenced-by-count":2,"title":["The Impact of\n                    <i>Chlamydia trachomatis<\/i>\n                    on Male Infertility: A Systematic Review and Meta-Analysis"],"prefix":"10.1093","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8409-868X","authenticated-orcid":false,"given":"Nicola Luigi","family":"Bragazzi","sequence":"first","affiliation":[{"name":"Laboratory for Industrial and Applied Mathematics (LIAM), Department of Mathematics and Statistics, York University , Toronto, Ontario ,","place":["Canada"]},{"name":"Department of Food and Drugs, University of Parma , Parma ,","place":["Italy"]},{"name":"Department of 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