{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T13:36:29Z","timestamp":1783776989566,"version":"3.55.0"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T00:00:00Z","timestamp":1766448000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,12,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Candidemia is a life-threatening infection with high mortality, and appropriate management is essential to improve patient outcomes. The Candida Care Bundle aims to standardize hospital management for patients with candidemia and reduce mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective multicenter cohort study included candidemia cases from 9 hospitals in Japan between 2016 and 2023. Compliance to the Candida Care Bundle was evaluated based on 5 elements: central venous catheter removal within 24\u2005hours, appropriate antifungal therapy, ophthalmologic examination, follow-up blood cultures, and antifungal treatment for \u22652 weeks after clearance. Patients were categorized into high (4\u20135 items) and low (0\u20133 items) compliance groups. The primary and secondary outcomes were defined as 30-day survival and the development of endophthalmitis, with propensity score matching used to adjust for potential confounders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 230 patients, 160 (69.5%) were classified into the high compliance group, which exhibited significantly lower 30-day mortality than the low compliance group (8.8% vs 57.1%, P &amp;lt; .01). Even after matching, the high compliance group remained independently associated with improved survival (hazard ratio [HR]: 0.15; 95% confidence interval [CI]: .08\u2013.30). C. albicans (HR: 1.95; 95% CI: 1.01\u20133.52) and central line-associated bloodstream infection (HR: 2.63; 95% CI: 1.35\u20135.12) were associated with the fatal outcome. Endophthalmitis involved 23.6% of the patients, being associated with C. albicans (odds ratio [OR]: 8.18; 4.46\u201319.30) and central line-associated bloodstream infection (OR: 2.69; 1.08\u20136.70).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Strict compliance to the Candida Care Bundle significantly improves survival, underscoring its importance in candidemia management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ofid\/ofaf790","type":"journal-article","created":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T12:47:14Z","timestamp":1766234834000},"source":"Crossref","is-referenced-by-count":1,"title":["Impact of Candida Care Bundle Compliance on the Prognosis of Patients With Candidemia: A Multicenter Retrospective Cohort Study With Propensity Score Matching Analysis (2016\u20132023)"],"prefix":"10.1093","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-1123-7991","authenticated-orcid":false,"given":"Hidemasa","family":"Akazawa","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, Okayama University Hospital , Okayama ,","place":["Japan"]},{"name":"Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences , Okayama ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinnosuke","family":"Fukushima","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Okayama University Hospital , Okayama ,","place":["Japan"]},{"name":"Department of Bacteriology, Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences , Okayama ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshie","family":"Higuchi","sequence":"additional","affiliation":[{"name":"Department of General Internal Medicine, Okayama Red Cross Hospital , Okayama ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoko","family":"Miyoshi","sequence":"additional","affiliation":[{"name":"Center for Medical Education and Internationalization, Kyoto University Graduate School of Medicine , Kyoto ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9972-791X","authenticated-orcid":false,"given":"Yasuhiro","family":"Nakano","sequence":"additional","affiliation":[{"name":"Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences , Okayama 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