{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T09:56:02Z","timestamp":1793094962052,"version":"4.5.0"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T00:00:00Z","timestamp":1767052800000},"content-version":"vor","delay-in-days":4,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","award":["75437419"],"award-info":[{"award-number":["75437419"]}],"id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Sofie Vanmechelen and Kurt Beuselinck"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,12,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Mucormycosis is a severe fungal infection that is challenging to diagnose as traditional methods lack sensitivity and serological testing is unavailable. This study aimed to evaluate the MucorGenius\u00ae PCR assay on respiratory and biopsy samples from high-risk patients with probable\/proven invasive pulmonary aspergillosis (IPA), mucormycosis, or possible invasive mold infections (IMIs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This multicenter cohort study was conducted across 4 sites in Austria, Belgium and the UK. A total of 132 respiratory and biopsy samples from 114 patients with IMI diagnosed in clinical routine (10 proven IPA, 13 proven mucormycosis, 62 probable IPA, 5 probable mucormycosis, and 35 possible IMI according to EORTC\/MSGERC 2020 and FUNDICU criteria; 11 IPA\/mucormycosis coinfections) were analyzed using the MucorGenius\u00ae PCR assay in ISO-certified laboratories. Results were compared with standard fungal diagnostics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Mucorales DNA was detected in 37\/132 samples (28%) including 29 BAL fluids, 1 bronchial aspirate, 1 endotracheal aspirate, and 6 biopsies from 37 patients. Sensitivity was 94.4% (17\/18) for detecting probable\/proven mucormycosis (including 11 cases routinely diagnosed with IPA\/mucormycosis coinfection). Among 72 patients with probable\/proven IPA, 21 (29.2%) tested positive for Mucorales DNA, including 11 missed by routine diagnostics. Mucorales DNA was also detected in 9\/35 (25.7%) of patients with possible IMI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>MucorGenius\u00ae PCR showed high sensitivity for detecting Mucorales and may support improved diagnosis of probable mucormycosis when included as a mycological criterion. It appears particularly valuable for identifying Aspergillus-Mucorales coinfections and detecting mucormycosis in patients with host factors, clinical or radiological evidence of IMI when routine diagnostics are negative.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ofid\/ofaf801","type":"journal-article","created":{"date-parts":[[2025,12,25]],"date-time":"2025-12-25T12:48:24Z","timestamp":1766666904000},"source":"Crossref","is-referenced-by-count":6,"title":["Mucorales PCR Testing in Respiratory and Biopsy Samples From Immunocompromised Patients With Invasive Pulmonary Aspergillosis and Other Mold Infections: Results From a Multicenter ECMM Study"],"prefix":"10.1093","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-3070-2508","authenticated-orcid":false,"given":"Sarah","family":"Sedik","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Division of Infectious Diseases, Medical University of Graz, Translational Mycology Research 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,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P Lewis","family":"White","sequence":"additional","affiliation":[{"name":"Public Health Wales Mycology Reference Laboratory and Cardiff University Centre for Trials Research , University Hospital of Wales, Cardiff ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel B","family":"Posso","sequence":"additional","affiliation":[{"name":"Public Health Wales Mycology Reference Laboratory and Cardiff University Centre for Trials Research , University Hospital of Wales, Cardiff ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silke","family":"Schelenz","sequence":"additional","affiliation":[{"name":"Infection Sciences, King's College Hospital , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alireza","family":"Abdolrasouli","sequence":"additional","affiliation":[{"name":"Infection Sciences, King's College Hospital , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4031-0778","authenticated-orcid":false,"given":"Jochem B","family":"Buil","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Radboud University Medical Center , Nijmegen ,","place":["The Netherlands"]},{"name":"Radboudumc-CWZ Center of Expertise for Mycology , Department of Medical Microbiology, Nijmegen ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl","family":"Dichtl","sequence":"additional","affiliation":[{"name":"Diagnostic and Research Institute of Hygiene, Microbiology and Environmental Medicine, Medical University of Graz , Graz ,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harald H","family":"Kessler","sequence":"additional","affiliation":[{"name":"Diagnostic and Research Institute of Hygiene, Microbiology and 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