{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T14:05:39Z","timestamp":1771337139756,"version":"3.50.1"},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T00:00:00Z","timestamp":1771286400000},"content-version":"vor","delay-in-days":16,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Paratek Pharmaceuticals"},{"DOI":"10.13039\/100007144","name":"University of Houston","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007144","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Omadacycline, an aminomethylcycline tetracycline available orally and intravenously, is approved for the treatment of patients with acute bacterial skin and skin structure infections and community-acquired bacterial pneumonia, some of whom have difficulty swallowing tablets. The objective of this study was to assess the stability and recovery of crushed omadacycline 150-mg tablets.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The recovery and stability of crushed omadacycline 150-mg tablets was assessed using 3 crushing methods (pill crusher, mortar\/pestle, and sandwich bag method) and 3 dispersal products (water, vanilla syrup, or applesauce) over 24\u2005hours at room temperature and administered via nasogastric tube. Omadacycline and its epimer (OMC-4-epimer) concentrations were assessed via liquid chromatography tandem mass spectrometry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>There was no significant difference in recovery of omadacycline or OMC-4-epimer proportion based on crushing technique. There were significantly higher proportions of OMC-4-epimer in applesauce experiments than in water or vanilla syrup experiments, regardless of crushing methods. All experiments had significantly less recovery of omadacycline and increased proportions of OMC-4-epimer at 24\u2005hours compared with earlier time points. There was no significant difference in recovery of omadacycline or OMC-4-epimer proportion using either type of nasogastric tube with omadacycline recovery above 91%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The optimal method for recovery and stability of crushed omadacycline was to rinse the crushing device thoroughly into the collection container and disperse it into water, with consumption immediately or after no more than 4\u2005hours. Vanilla syrup may be used as an alternative dispersal vehicle to be consumed immediately if used.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ofid\/ofag011","type":"journal-article","created":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T12:38:47Z","timestamp":1769171927000},"source":"Crossref","is-referenced-by-count":0,"title":["Recovery and Stability of Omadacycline 150-mg Crushed Tablets Dispersed in Food or Water and Administered via Nasogastric Tube"],"prefix":"10.1093","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0444-2127","authenticated-orcid":false,"given":"Chenlin","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Practice and Translational Research, University of Houston College of Pharmacy , Houston, Texas 77204 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-0892-0577","authenticated-orcid":false,"given":"Ricky","family":"Huynh-Phan","sequence":"additional","affiliation":[{"name":"Department of Practice and Translational Research, University of Houston College of Pharmacy , Houston, Texas 77204 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2593-6102","authenticated-orcid":false,"given":"Kevin M","family":"Rodriguez Robles","sequence":"additional","affiliation":[{"name":"Department of Practice and Translational Research, University of Houston College of Pharmacy , Houston, Texas 77204 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6645-406X","authenticated-orcid":false,"given":"Taryn A","family":"Eubank","sequence":"additional","affiliation":[{"name":"Department of Practice and Translational Research, University of Houston College of Pharmacy , Houston, Texas 77204 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2063-7503","authenticated-orcid":false,"given":"Kevin W","family":"Garey","sequence":"additional","affiliation":[{"name":"Department of Practice and Translational Research, University of Houston College of Pharmacy , Houston, Texas 77204 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2026,2,17]]},"reference":[{"key":"2026021708012978700_ofag011-B1","doi-asserted-by":"crossref","first-page":"S6","DOI":"10.1093\/cid\/ciz395","article-title":"Microbiology and preclinical review of omadacycline","volume":"69","author":"Karlowsky","year":"2019","journal-title":"Clin Infect Dis"},{"key":"2026021708012978700_ofag011-B2","author":"Paratek 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implications for clinical strategy and study performance based on BE studies of rivaroxaban and deferasirox","volume":"17","author":"Sus","year":"2024","journal-title":"Clin Transl Sci"},{"key":"2026021708012978700_ofag011-B7","doi-asserted-by":"crossref","first-page":"124057","DOI":"10.1016\/j.jchromb.2024.124057","article-title":"Development and validation of LC-MS\/MS for quantifying omadacycline from stool for gut microbiome studies","volume":"1236","author":"Hu","year":"2024","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"key":"2026021708012978700_ofag011-B8","doi-asserted-by":"crossref","first-page":"2848","DOI":"10.1021\/ja01568a050","article-title":"Studies of the reversible epimerization occurring in the tetracycline family\u2014the preparation, properties and proof of structure of some 4-epi-tetracyclines","volume":"79","author":"Mccormick","year":"1957","journal-title":"J Am Chem 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tetracyclines","volume":"11","author":"Neuvonen","year":"1976","journal-title":"Drugs"},{"key":"2026021708012978700_ofag011-B12","doi-asserted-by":"crossref","first-page":"2291","DOI":"10.1111\/1750-3841.16155","article-title":"An apple a day keeps the doctor away: the potentials of apple bioactive constituents for chronic disease prevention","volume":"87","author":"Oyenihi","year":"2022","journal-title":"J Food Sci"},{"key":"2026021708012978700_ofag011-B13","doi-asserted-by":"crossref","first-page":"121807","DOI":"10.1016\/j.jchromb.2019.121807","article-title":"Challenges in the bioanalysis of tetracyclines: epimerisation and chelation with metals","volume":"1134-1135","author":"Bayliss","year":"2019","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"}],"container-title":["Open Forum Infectious 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