{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T13:13:37Z","timestamp":1780578817851,"version":"3.54.1"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:00:00Z","timestamp":1780358400000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Scedosporium spp and Lomentospora prolificans are rare fungi involved in mold endocarditis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We reported cases of Scedosporium spp and L prolificans endocarditis from the French Scedosporiosis\/Lomentosporiosis Observational Study (S.O.S.) and performed a literature review of previous reported cases in order to describe their predisposing risk factors, clinical presentation, treatment, and outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We included 30 cases including 4 new cases from the S.O.S. Sixty percent (18\/30) of the cases were due to Scedosporium apiospermum complex and 37% (11\/30) to L prolificans. Trauma was the main invasive fungal disease host factor (12\/30 [40%]), followed by solid organ transplant (10\/30 [33%]), short posttransplant delay (median of 45 days), and malignancy (5\/30 [17%]). No endocarditis predisposing condition was found in immunocompromised patients (0\/16). Eleven cases were healthcare-associated infections (37%). Septic emboli were reported in 93% of the cases (28\/30), affecting mainly the central nervous system (CNS) (68%). Pulmonary emboli were present in all right-sided endocarditis (8\/8). Blood cultures were negative in 6 cases (27% [6\/26]). Surgical valve replacement was performed in 50% of the cases (8\/16). Mortality was high whether patients were treated with antifungals only (7\/8 [88%]) or with antifungals and surgery (5\/7 [71%]). Mortality rose to 100% in the case of CNS emboli.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Scedosporium spp and L prolificans endocarditis is a life-threatening fungal disease occurring in both immunocompromised and immunocompetent hosts. It should be considered in the presence of fungemia or embolic complications, particularly in the CNS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ofid\/ofag123","type":"journal-article","created":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T11:47:48Z","timestamp":1779968868000},"source":"Crossref","is-referenced-by-count":0,"title":["Endocarditis Due to\n                    <i>Scedosporium<\/i>\n                    spp and\n                    <i>Lomentospora prolificans<\/i>\n                    : Case Series and Literature Review"],"prefix":"10.1093","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-5829-8962","authenticated-orcid":false,"given":"Carole","family":"Vignals","sequence":"first","affiliation":[{"name":"Service de Maladies Infectieuses et Tropicales, H\u00f4pital Necker-Enfants Malades, Universit\u00e9 Paris Cit\u00e9, Assistance Publique\u2013H\u00f4pitaux de Paris , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9629-5864","authenticated-orcid":false,"given":"Julien","family":"Ternacle","sequence":"additional","affiliation":[{"name":"Unit\u00e9 M\u00e9dico-Chirurgicale des valvulopathies, H\u00f4pital Haut-L\u00e9v\u00eaque, Centre Hospitalier Universitaire de Bordeaux , Pessac ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5288-2904","authenticated-orcid":false,"given":"Dea","family":"Garcia-Hermoso","sequence":"additional","affiliation":[{"name":"Centre National de R\u00e9f\u00e9rence Mycoses Invasives et Antifongiques, D\u00e9partement de Mycologie, Institut Pasteur, Universit\u00e9 Paris Cit\u00e9 , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2209-2087","authenticated-orcid":false,"given":"Joseph","family":"Emmerich","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Vasculaire, Groupe Hospitalier Paris Saint-Joseph , Universit\u00e9 Paris Cit\u00e9, Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilie","family":"Catherinot","sequence":"additional","affiliation":[{"name":"Servicde de Pneumologie, H\u00f4pital Foch , Suresnes ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7489-9205","authenticated-orcid":false,"given":"Laurence","family":"Delhaes","sequence":"additional","affiliation":[{"name":"Centre National de R\u00e9f\u00e9rence des Aspergilloses Chroniques, Universitaire de Bordeaux , Bordeaux ,","place":["France"]},{"name":"Service de Parasitologie-Mycologie, Universit\u00e9 de Bordeaux , CHU de Bordeaux, Bordeaux ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2694-7660","authenticated-orcid":false,"given":"Delphine","family":"Horeau-Langlard","sequence":"additional","affiliation":[{"name":"Service de Pneumologie, H\u00f4pital La\u00ebnnec, Centre Hospitalier Universitaire de \u00a0 Nantes, Nantes ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0886-7699","authenticated-orcid":false,"given":"Jean-Philippe","family":"Martellosio","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine interne, Maladies Infectieuses et Tropicales, Centre Hospitalier Universitaire de Poitiers , Poitiers ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5859-6105","authenticated-orcid":false,"given":"Florent","family":"Morio","sequence":"additional","affiliation":[{"name":"Service de Mycologie M\u00e9dicale, Centre Hospitalier Universitaire de Nantes , Nantes ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8325-8060","authenticated-orcid":false,"given":"Olivier","family":"Lortholary","sequence":"additional","affiliation":[{"name":"Service de Maladies Infectieuses et Tropicales, H\u00f4pital Necker-Enfants Malades, Universit\u00e9 Paris Cit\u00e9, Assistance Publique\u2013H\u00f4pitaux de Paris , Paris ,","place":["France"]},{"name":"Centre National de R\u00e9f\u00e9rence Mycoses Invasives et Antifongiques, D\u00e9partement de Mycologie, Institut Pasteur, Universit\u00e9 Paris Cit\u00e9 , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0355-7520","authenticated-orcid":false,"given":"Mathilde","family":"Puges","sequence":"additional","affiliation":[{"name":"Service des Maladies Infectieuses et Tropicales, Centre Hospitalier Universitaire de Bordeaux, Universit\u00e9 de Bordeaux , Bordeaux ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanny","family":"Lanternier","sequence":"additional","affiliation":[{"name":"Service de Maladies Infectieuses et Tropicales, H\u00f4pital Necker-Enfants Malades, Universit\u00e9 Paris Cit\u00e9, Assistance Publique\u2013H\u00f4pitaux de Paris , Paris ,","place":["France"]},{"name":"Centre National de R\u00e9f\u00e9rence Mycoses Invasives et Antifongiques, D\u00e9partement de Mycologie, Institut Pasteur, Universit\u00e9 Paris Cit\u00e9 , Paris 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