{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T15:14:12Z","timestamp":1778080452059,"version":"3.51.4"},"reference-count":84,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T00:00:00Z","timestamp":1775433600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chronic pulmonary aspergillosis (CPA) affects those with underlying lung conditions or mild immunocompromise. Chronic pulmonary aspergillosis carries a poor prognosis in adults. Its pathogenesis remains obscure. We summarize all cases of CPA in children globally.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>From 6503 screened reports, we reviewed the full text of 604, of which 44 fit the inclusion criteria and an additional 11 other cases with little detail which were included under Supplementary Data. Chronic granulomatous disease and cystic fibrosis cases were excluded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We found 47 well-documented individual cases of CPA in children published from 1963 to 2022. Twenty-two cases were simple aspergillomas, and 11 were chronic cavitary pulmonary aspergillosis. Ages ranged from under 1 year to 17 years old, and 28 (59.8%) were male. Eighteen (38.3%) cases had no reported underlying disease. Underlying diseases included pulmonary tuberculosis (14.9%), Job's Syndrome (10.6%), congenital pulmonary airway malformation (8.5%), allergic bronchopulmonary aspergillosis or asthma (6.4%), pulmonary hydatid cyst (4.3%), bacterial pneumonia with cavitation (4.3%), diabetes mellitus (4.3%), and single cases of pulmonary sequestration or bronchogenic cyst. All cases had either microbiological or immunological evidence of Aspergillus spp. apart from 2 confirmed by histopathology only. Surgical resection only was done in 18 (39.1%) patients, 15 (32.6%) were treated with surgery and antifungal therapy, and 13 (28.3%) were only treated with antifungals; one patient died before intervention. Forty-three cases (91.5%) were alive on hospital discharge, but follow-up was limited, while 2 died.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Chronic pulmonary aspergillosis is apparently rare in children but does occur, often with no antecedent condition. Prognosis is good with early diagnosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ofid\/ofag186","type":"journal-article","created":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T12:45:34Z","timestamp":1774615534000},"source":"Crossref","is-referenced-by-count":0,"title":["Chronic Pulmonary Aspergillosis in Children: A Scoping Global Review"],"prefix":"10.1093","volume":"13","author":[{"given":"Filip","family":"Pavlovic","sequence":"first","affiliation":[{"name":"School of Medicine, The University of Manchester , Manchester ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5270-3539","authenticated-orcid":false,"given":"Richard","family":"Kwizera","sequence":"additional","affiliation":[{"name":"College of Health Sciences, Makerere University Infectious Diseases Institute, , P.O. Box 22418, Kampala ,","place":["Uganda"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5626-2251","authenticated-orcid":false,"given":"David W","family":"Denning","sequence":"additional","affiliation":[{"name":"Manchester Fungal Infection Group, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester Academic Health Science Centre , Manchester ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2026,4,6]]},"reference":[{"key":"2026050610383744500_ofag186-B1","first-page":"673","article-title":"Chronic pulmonary aspergillosis: a brief review","volume":"94","author":"Zarif","year":"2021","journal-title":"Yale J Biol Med"},{"key":"2026050610383744500_ofag186-B2","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1183\/09031936.00054810","article-title":"Underlying conditions in chronic pulmonary aspergillosis including simple aspergilloma","volume":"37","author":"Smith","year":"2011","journal-title":"Eur Respir J"},{"key":"2026050610383744500_ofag186-B3","doi-asserted-by":"crossref","first-page":"e428","DOI":"10.1016\/S1473-3099(23)00692-8","article-title":"Global incidence and mortality of severe fungal disease","volume":"24","author":"Denning","year":"2024","journal-title":"Lancet Infect Dis"},{"key":"2026050610383744500_ofag186-B4","doi-asserted-by":"crossref","first-page":"S104","DOI":"10.1093\/mmy\/myy070","article-title":"Chronic pulmonary aspergillosis update: a year in review","volume":"57","author":"Barac","year":"2019","journal-title":"Med Mycol"},{"key":"2026050610383744500_ofag186-B5","doi-asserted-by":"crossref","first-page":"864","DOI":"10.2471\/BLT.11.089441","article-title":"Global burden of chronic pulmonary aspergillosis as a sequel to pulmonary tuberculosis","volume":"89","author":"Denning","year":"2011","journal-title":"Bull World Health Organ"},{"key":"2026050610383744500_ofag186-B6","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/S1473-3099(24)00567-X","article-title":"Mortality in chronic pulmonary aspergillosis: a systematic review and individual patient data meta-analysis","volume":"25","author":"Sengupta","year":"2025","journal-title":"Lancet Infect Dis"},{"key":"2026050610383744500_ofag186-B7","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1183\/13993003.00583-2015","article-title":"Chronic pulmonary aspergillosis: rationale and clinical guidelines for diagnosis and management","volume":"47","author":"Denning","year":"2015","journal-title":"Eur Respir J"},{"key":"2026050610383744500_ofag186-B8","first-page":"759","article-title":"Apparently primary pulmonary aspergilloma in a 4-year-old girl","volume":"18","author":"Chaptal","year":"1963","journal-title":"Pediatrie (Bucur)"},{"key":"2026050610383744500_ofag186-B9","first-page":"1","article-title":"Experiences with the treatment of 3 cases of lung aspergillosis","volume":"12","author":"Miyamoto","year":"1963","journal-title":"Kyoto Daigaku Kekkaku Kenkyusho Kiyo"},{"key":"2026050610383744500_ofag186-B10","first-page":"473","article-title":"Pulmonary aspergillosis in childhood","volume":"114","author":"Krenmayr","year":"1964","journal-title":"Wien Med Wochenschr"},{"key":"2026050610383744500_ofag186-B11","first-page":"233","article-title":"Secondary pulmonary aspergilloma in a 4-year-old girl","volume":"18","author":"Besa","year":"1966","journal-title":"Minerva Pediatr"},{"key":"2026050610383744500_ofag186-B12","first-page":"37","article-title":"[Intrabronchial aspergillosis. 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