{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:42:59Z","timestamp":1790959379747,"version":"4.1.0"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T00:00:00Z","timestamp":1775088000000},"content-version":"vor","delay-in-days":3,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100020950","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["NSTC 112-2314-B-A49-029"],"award-info":[{"award-number":["NSTC 112-2314-B-A49-029"]}],"id":[{"id":"10.13039\/501100020950","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020950","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["NSTC 114-2314-B-A49-079-MY3"],"award-info":[{"award-number":["NSTC 114-2314-B-A49-079-MY3"]}],"id":[{"id":"10.13039\/501100020950","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011912","name":"Taipei Veterans General Hospital","doi-asserted-by":"publisher","award":["V112C-102"],"award-info":[{"award-number":["V112C-102"]}],"id":[{"id":"10.13039\/501100011912","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011912","name":"Taipei Veterans General Hospital","doi-asserted-by":"publisher","award":["V113C-073"],"award-info":[{"award-number":["V113C-073"]}],"id":[{"id":"10.13039\/501100011912","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011912","name":"Taipei Veterans General Hospital","doi-asserted-by":"publisher","award":["V114C-047"],"award-info":[{"award-number":["V114C-047"]}],"id":[{"id":"10.13039\/501100011912","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011912","name":"Taipei Veterans General Hospital","doi-asserted-by":"publisher","award":["V115C-170"],"award-info":[{"award-number":["V115C-170"]}],"id":[{"id":"10.13039\/501100011912","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011912","name":"Taipei Veterans General Hospital","doi-asserted-by":"publisher","award":["V115B-001"],"award-info":[{"award-number":["V115B-001"]}],"id":[{"id":"10.13039\/501100011912","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Szu-Yuan Research Foundation of Internal Medicine"},{"name":"Y.L. Lin Hung Tai Education Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Klebsiella pneumoniae liver abscesses (KPLA) remain endemic to Taiwan. Hypervirulent strains in the gut can translocate across colonic mucosal defects into the portal circulation, causing subsequent liver abscesses. Occult colorectal cancer in patients with KPLA has been reported in a case series. Herein, we determined whether the diagnosis of KPLA serves as a harbinger of colorectal neoplasms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Consecutive patients with KPLA treated at Taipei Veterans General Hospital in Taiwan between April 2011 and January 2024 were retrospectively enrolled. Hypervirulent K. pneumoniae strains were defined as those harboring mutations in rmpA or rmpA2. Patients who underwent colonoscopy within 6 months of diagnosis were included in the analysis. Logistic regression was used to assess the risk factors for colorectal adenomas and adenocarcinomas.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 489 patients with KPLA were identified during the study period, of which 114 (23.3%) underwent colonoscopy within 6 months of the diagnosis of KPLA. Most K. pneumoniae strains were hypervirulent (95.1%). Colonoscopy findings showed 48 (42.1%) cases of adenomas and 13 (11.4%) of adenocarcinomas. Age \u2265 50 years was the only independent factor for colorectal adenoma\/adenocarcinoma (odds ratio = 5.728, 95% CI = 2.045\u201316.04, P = .001). During follow-up, most patients with adenocarcinoma (11\/13, 84.6%) remained disease-free post-surgery. Of the 48 patients with adenomas, 2 developed colorectal cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Colorectal adenomas and adenocarcinomas are common in patients with KPLA. Colonoscopy should be routinely performed in patients with KPLA, particularly those aged \u2265 50 years.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ofid\/ofag191","type":"journal-article","created":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T11:44:25Z","timestamp":1775043865000},"source":"Crossref","is-referenced-by-count":1,"title":["<i>Klebsiella Pneumoniae<\/i>\n                    Liver Abscess as the Herald of Underlying Colorectal Neoplasm"],"prefix":"10.1093","volume":"13","author":[{"given":"Tsen-En","family":"Liao","sequence":"first","affiliation":[{"name":"Institute of Emergency and Critical Care Medicine, National Yang Ming Chiao Tung University , Taipei ,","place":["Taiwan"]},{"name":"Center for Infection Control, Taipei Veterans General Hospital , Taipei ,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien","family":"Chuang","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Taipei Veterans General Hospital , Taipei ,","place":["Taiwan"]},{"name":"School of Medicine, College of Medicine, National Yang Ming Chiao Tung University , Taipei ,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Szu-Yu","family":"Liu","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Taipei Veterans General Hospital , Taipei ,","place":["Taiwan"]},{"name":"School of Medicine, College of Medicine, National Yang Ming Chiao Tung University , Taipei ,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Chien","family":"Ho","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Taipei Veterans General Hospital , Taipei ,","place":["Taiwan"]},{"name":"School of Medicine, College of Medicine, National Yang Ming Chiao Tung University , Taipei ,","place":["Taiwan"]},{"name":"Department of Medicine, Kinmen Hospital, Ministry of Health and Welfare , Kinmen ,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan","family":"Chin","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Taipei Veterans General Hospital , Taipei ,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng-Hua","family":"Chou","sequence":"additional","affiliation":[{"name":"Institute of Emergency and Critical Care Medicine, National Yang Ming Chiao Tung University , Taipei ,","place":["Taiwan"]},{"name":"Center for Infection Control, Taipei Veterans General Hospital , Taipei ,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9940-7529","authenticated-orcid":false,"given":"Yi-Tsung","family":"Lin","sequence":"additional","affiliation":[{"name":"Institute of Emergency and Critical Care Medicine, National Yang Ming Chiao Tung University , Taipei ,","place":["Taiwan"]},{"name":"Center for Infection Control, Taipei Veterans General Hospital , Taipei ,","place":["Taiwan"]},{"name":"Division of Infectious Diseases, Department of Medicine, Taipei Veterans General Hospital , Taipei ,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,4,2]]},"reference":[{"key":"2026041703022697600_ofag191-B1","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.jmii.2014.08.028","article-title":"Epidemiology and clinical outcome of pyogenic liver abscess: an analysis from the national health insurance research database of Taiwan, 2000-2011","volume":"49","author":"Chen","year":"2016","journal-title":"J Microbiol Immunol Infect"},{"key":"2026041703022697600_ofag191-B2","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1093\/infdis\/jit157","article-title":"Ampicillin and amoxicillin use and the risk of Klebsiella pneumoniae 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