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This regimen is associated with significant salt and volume administration in a patient population susceptible to the development of hypervolemia and heart failure, which are associated with worse clinical outcomes. As a consequence of Hurricane Helene, the United States experienced significant intravenous fluid shortages in 2024 and 2025, prompting hospitals to switch from infusion delivery to push administration of many medications, without reported deleterious effects. Push administration of ampicillin and ceftriaxone and the evidence-based use of partial oral antibiotic therapy are treatment strategies that may help reduce the incidence of hypervolemia and\/or heart failure in patients with E faecalis endocarditis.<\/jats:p>","DOI":"10.1093\/ofid\/ofag199","type":"journal-article","created":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T11:30:24Z","timestamp":1779017424000},"source":"Crossref","is-referenced-by-count":0,"title":["When Less Is More: Volume Considerations in the Treatment of\n                    <i>Enterococcus faecalis<\/i>\n                    Endocarditis"],"prefix":"10.1093","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2603-2951","authenticated-orcid":false,"given":"Sami","family":"El-Dalati","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, Department of Internal Medicine, University of Kentucky HealthCare , Lexington, Kentucky ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0979-3841","authenticated-orcid":false,"given":"William","family":"Harris","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Services, University of Kentucky HealthCare , Lexington, Kentucky ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,5,20]]},"reference":[{"key":"2026052111143231600_ofag199-B1","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1016\/j.athoracsur.2006.10.076","article-title":"Cardiac surgery in patients with body mass index of 50 or greater","volume":"83","author":"Villavicencio","year":"2007","journal-title":"Ann Thorac Surg"},{"key":"2026052111143231600_ofag199-B2","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1161\/CIR.0000000000000296","article-title":"Infective endocarditis in adults: diagnosis, antimicrobial therapy, and management of complications a scientific statement for healthcare professionals from the American Heart Association","volume":"132","author":"Baddour","year":"2015","journal-title":"Circulation"},{"key":"2026052111143231600_ofag199-B3","first-page":"3075","article-title":"Guidelines for the management of infective endocarditis: the task force for the management of infective endocarditis of the European Society of Cardiology (ESC). 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