{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T08:06:49Z","timestamp":1779437209639,"version":"3.53.1"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T00:00:00Z","timestamp":1777161600000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Infective endocarditis (IE) remains a severe condition with high morbidity and mortality despite advances in diagnostics and therapy. Health-related quality of life (HRQL) is an important outcome, yet high-quality data on HRQL in patients with IE are limited as most studies focused exclusively on surgically treated patients and did not assess HRQL at a defined time point.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A cross-sectional analysis was performed on HRQL data from 259 patients diagnosed with IE between 11\/2019 and 09\/2023, derived from the prospective German DERIVE cohort. HRQL was evaluated 12 months after diagnosis using the EQ-5D-5L questionnaire and the EQ visual analog scale (EQ-VAS). Descriptive and nonparametric analyses were applied to compare HRQL across subgroups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 338 one-year survivors, complete HRQL data were available for 259 patients (77%). The median EQ-5D index (interquartile range) was 0.91 (0.73\u20130.97), indicating persistent impairment compared with the general population. Female patients had lower HRQL than males (median EQ-5D index, 0.89 vs 0.91) and higher impairments in anxiety, pain, and usual activities. Younger patients (&amp;lt;55 years) experienced higher overall HRQL but more pain and anxiety, while patients older than 65 years reported greater physical limitations. No significant difference in EQ-5D index was observed between surgically and conservatively treated patients (0.91 vs 0.90); however, surgically treated patients reported higher levels of anxiety 1 year after diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Patients with IE experience persistent reductions in HRQL 1 year after diagnosis, affecting nearly all domains of daily life. The data highlight the importance of incorporating patient-reported outcomes into clinical management and long-term follow-up.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ofid\/ofag238","type":"journal-article","created":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T11:30:48Z","timestamp":1776771048000},"source":"Crossref","is-referenced-by-count":0,"title":["Health-Related Quality of Life of Patients With Infective Endocarditis\u2014A Cross-Sectional Study Based on Data From the DERIVE Cohort"],"prefix":"10.1093","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6711-6516","authenticated-orcid":false,"given":"Charlotte","family":"Meyer-Schwickerath","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, Department I of Internal Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne , Cologne ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4426-9565","authenticated-orcid":false,"given":"Kirsten","family":"Schmidt-Hellerau","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department I of Internal Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne , Cologne ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Camp","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine II, Medical Centre-University of Freiburg, Faculty of Medicine, University of Freiburg , Freiburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Last","sequence":"additional","affiliation":[{"name":"Institute of Medical Microbiology and Hygiene, Saarland University , Homburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Insa","family":"Joost","sequence":"additional","affiliation":[{"name":"Institute of Medical Microbiology and Hospital Hygiene, Heinrich-Heine-University Du\u0308sseldorf , Du\u0308sseldorf ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2821-4134","authenticated-orcid":false,"given":"Christopher","family":"Hohmann","sequence":"additional","affiliation":[{"name":"Department III of Internal Medicine, Heart Center, Faculty of Medicine and University Hospital of Cologne , Cologne ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8490-5549","authenticated-orcid":false,"given":"Carolyn","family":"Weber","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Faculty of Medicine and University Hospital of Cologne , Cologne ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7493-7080","authenticated-orcid":false,"given":"Siegbert","family":"Rieg","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine II, Medical Centre-University of Freiburg, Faculty of Medicine, University of Freiburg , Freiburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norma","family":"Jung","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department I of Internal Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne , Cologne ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,4,25]]},"reference":[{"key":"2026052203413727100_ofag238-B1","doi-asserted-by":"crossref","first-page":"3233","DOI":"10.1093\/eurheartj\/ehz694","article-title":"Infective endocarditis: an ongoing global challenge","volume":"40","author":"Miro","year":"2019","journal-title":"Eur Heart J"},{"key":"2026052203413727100_ofag238-B2","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1001\/archinternmed.2008.603","article-title":"Clinical presentation, etiology, and outcome of infective endocarditis in the 21st century: the International Collaboration on Endocarditis-Prospective Cohort Study","volume":"169","author":"Murdoch","year":"2009","journal-title":"Arch Intern Med"},{"key":"2026052203413727100_ofag238-B3","doi-asserted-by":"crossref","first-page":"3222","DOI":"10.1093\/eurheartj\/ehz620","article-title":"Clinical presentation, aetiology and outcome of infective endocarditis. 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