{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T16:56:44Z","timestamp":1781283404776,"version":"3.54.1"},"reference-count":56,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:00:00Z","timestamp":1779926400000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"US National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL141053"],"award-info":[{"award-number":["R01HL141053"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"US National Institutes of Health","doi-asserted-by":"publisher","award":["D43TW010543"],"award-info":[{"award-number":["D43TW010543"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"US National Institutes of Health","doi-asserted-by":"publisher","award":["5P30AI060354-18"],"award-info":[{"award-number":["5P30AI060354-18"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"US National Institutes of Health","doi-asserted-by":"publisher","award":["K43TW012846"],"award-info":[{"award-number":["K43TW012846"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"US National Institutes of Health","doi-asserted-by":"publisher","award":["K24HL166024"],"award-info":[{"award-number":["K24HL166024"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"US National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL167645"],"award-info":[{"award-number":["R01HL167645"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"US National Institutes of Health","doi-asserted-by":"publisher","award":["K43TW010715"],"award-info":[{"award-number":["K43TW010715"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"US National Institutes of Health","doi-asserted-by":"publisher","award":["K24 AA022586"],"award-info":[{"award-number":["K24 AA022586"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"US National Institutes of Health","doi-asserted-by":"publisher","award":["K24DA061696"],"award-info":[{"award-number":["K24DA061696"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Liver disease is an important cause of morbidity and mortality among people with HIV (PWH). Steatotic liver disease (SLD) is a leading cause of liver disease among PWH in the Global North. However, there is a dearth of data on the epidemiology of SLD in sub-Saharan Africa.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed computed tomography images from a completed cohort study composed of ambulatory people with and without HIV. We defined SLD as 1 or more of the following: mean liver attenuation (density) &amp;lt;40 Hounsfield units, mean liver to mean spleen attenuation ratio &amp;lt;1, or a Hounsfield unit difference &amp;lt;1 between the mean attenuation values of the liver and spleen. We fit multivariable regression models to evaluate the association of HIV with SLD. In a subanalysis to explore HIV-specific effects, we excluded those who reported high-risk alcohol consumption.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 579 participants had interpretable liver images. The prevalence of SLD was low overall (22\/579, 3.8%) and higher among PWH as compared with people without HIV (5.4% vs 2.3%, P = .056). In multivariable regression models, PWH undergoing antiretroviral therapy were more likely to have SLD (adjusted odd ratio, 2.79; 95% CI, 1.10\u20137.09; P = .031), even after exclusion of people with high-risk alcohol consumption (adjusted odd ratio, 2.96; 95% CI, 1.00\u20138.70; P = .048).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We found a low overall prevalence of SLD in Uganda, but older PWH undergoing antiretroviral therapy had a higher prevalence of SLD than those without HIV. Variation in the prevalence of SLD in the African region may be due to the variability in the methods used.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ofid\/ofag325","type":"journal-article","created":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T11:21:42Z","timestamp":1779794502000},"source":"Crossref","is-referenced-by-count":0,"title":["Prevalence and Correlates of Steatotic Liver Disease Among People With HIV in Uganda"],"prefix":"10.1093","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7984-5775","authenticated-orcid":false,"given":"Prossy","family":"Bibangambah","sequence":"first","affiliation":[{"name":"Department of Radiology, Mbarara University of Science and Technology , Mbarara ,","place":["Uganda"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moses","family":"Acan","sequence":"additional","affiliation":[{"name":"Department of Radiology, Mbarara University of Science and Technology , Mbarara ,","place":["Uganda"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3865-3432","authenticated-orcid":false,"given":"Brian","family":"Ghoshhajra","sequence":"additional","affiliation":[{"name":"Department of Radiology, Harvard Medical School, Boston , Massachusetts ,","place":["USA"]},{"name":"Department of Radiology, Massachusetts General Hospital, Boston , Massachusetts ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1667-5219","authenticated-orcid":false,"given":"Geoffrey","family":"Erem","sequence":"additional","affiliation":[{"name":"Department of Radiology, Makerere University , Kampala ,","place":["Uganda"]},{"name":"Department of Radiology, Nsambya Hospital , Kampala ,","place":["Uganda"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Nassanga","sequence":"additional","affiliation":[{"name":"Department of Radiology, Makerere University , Kampala ,","place":["Uganda"]},{"name":"Department of Radiology, Nsambya Hospital , Kampala ,","place":["Uganda"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Ochieng","sequence":"additional","affiliation":[{"name":"Department of Radiology, Nsambya Hospital , Kampala ,","place":["Uganda"]},{"name":"Department of Radiology, Mulago National Referral Hospital , Kampala ,","place":["Uganda"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikas","family":"Thondapu","sequence":"additional","affiliation":[{"name":"Department of Radiology, Yale University School of Medicine , New Haven, Connecticut ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael T","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Medicine, Harvard Medical School , Boston, Massachusetts ,","place":["USA"]},{"name":"Department of Medicine, Massachusetts General Hospital , Boston, Massachusetts 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,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9468-0179","authenticated-orcid":false,"given":"Christopher T","family":"Longenecker","sequence":"additional","affiliation":[{"name":"Department of Global Health, University of Washington , Seattle, Washington ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6397-7917","authenticated-orcid":false,"given":"Alexander C","family":"Tsai","sequence":"additional","affiliation":[{"name":"Mbarara University of Science and Technology , Mbarara ,","place":["Uganda"]},{"name":"Department of Psychiatry, Harvard Medical School , Boston, Massachusetts ,","place":["USA"]},{"name":"Department of Psychiatry, Massachusetts General Hospital , Boston, Massachusetts ,","place":["USA"]},{"name":"Harvard T.H. Chan School of Public Health , Boston, Massachusetts ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9295-0035","authenticated-orcid":false,"given":"Jennifer M","family":"Manne-Goehler","sequence":"additional","affiliation":[{"name":"Department of Medicine, Brigham and Women's Hospital , Boston, Massachusetts ,","place":["USA"]},{"name":"Harvard T.H. Chan School of Public Health , Boston, Massachusetts ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Asiimwe","sequence":"additional","affiliation":[{"name":"Kabwohe Clinical Research Center , Kabwohe, Sheema ,","place":["Uganda"]},{"name":"Department of Community Health, Mbarara University of Science and Technology , Mbarara ,","place":["Uganda"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samson","family":"Okello","sequence":"additional","affiliation":[{"name":"Harvard T.H. 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