{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T18:45:54Z","timestamp":1782499554913,"version":"3.54.5"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:00:00Z","timestamp":1780444800000},"content-version":"vor","delay-in-days":2,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Shorter induction regimens for cryptococcal meningitis (CM) are being proposed, but data from resource-rich countries are limited. We compared clinical outcomes between short- (\u2264 1 week) and longer-duration (&amp;gt; 1 week) of liposomal amphotericin B (L-AmB) induction therapy and investigated factors associated with clinical outcomes at a United States medical center.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this retrospective study, cases of CM were identified by a positive cerebrospinal fluid (CSF) culture for Cryptococcus, cryptococcal antigen (CrAg), or India ink stain during 2016\u20132023. Clinical characteristics and outcomes including Glasgow Outcome Scale (GOS) at discharge, in-hospital mortality, and 90-day readmission between short-duration and longer-duration of L-AmB induction therapy were compared. Multivariable logistic regression was used to identify predictors of GOS at discharge and 90-day readmission.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 129 patients, 20 were in the short-duration (11 patients with HIV) and 109 in the longer-duration L-AmB group (72 with HIV). The short-duration group was less severely ill at baseline. Unfavorable GOS at discharge was 50.0% versus 61.5% (P = .34), in-hospital mortality 5.0% versus 5.5% (P = .93), and 90-day readmission 25.0% versus 38.5% (P = .24) in the short-duration and longer-duration groups, respectively. In multivariable analyses, higher CSF CrAg titer, acute kidney injury, and absence of photophobia were associated with unfavorable GOS at discharge, whereas L-AmB duration was not significantly associated. Association between L-AmB duration and 90-day readmission was inconsistent.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Short-duration L-AmB may have comparable outcomes to longer-duration in this cohort; further studies are needed to confirm these findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ofid\/ofag342","type":"journal-article","created":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T11:45:02Z","timestamp":1780141502000},"source":"Crossref","is-referenced-by-count":0,"title":["Cryptococcal Meningitis: Comparison of Short- (\u2264 1 Week) Versus Longer-duration (&amp;gt; 1 Week) Liposomal Amphotericin B Induction Therapy and Factors Associated With Clinical Outcomes in HIV and Non-HIV Patients"],"prefix":"10.1093","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5746-395X","authenticated-orcid":false,"given":"Sun O","family":"Park","sequence":"first","affiliation":[{"name":"Division of Infectious Disease, Department of Medicine, Keck School of Medicine, University of Southern California , Los Angeles, California ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5585-1675","authenticated-orcid":false,"given":"Matthew A","family":"Stack","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Allergy, and Immunology, Department of Medicine, Saint Louis University School of Medicine , St.Louis, Missouri ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7789-3681","authenticated-orcid":false,"given":"Ty C","family":"Drake","sequence":"additional","affiliation":[{"name":"Memorial Hermann Hospital-Texas Medical Center , Houston, Texas ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4155-7089","authenticated-orcid":false,"given":"Rodrigo","family":"Hasbun","sequence":"additional","affiliation":[{"name":"Division of Infectious Disease, Department of Medicine, University of Texas Health Science Center at Houston , Houston, Texas ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4784-7589","authenticated-orcid":false,"given":"Luis","family":"Ostrosky-Zeichner","sequence":"additional","affiliation":[{"name":"Division of Infectious Disease, Department of Medicine, University of Texas Health Science Center at Houston , Houston, Texas 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AIDS-associated acute cryptococcal meningitis: a randomized, double-blind clinical trial of efficacy and safety","volume":"51","author":"Hamill","year":"2010","journal-title":"Clin Infect Dis"},{"key":"2026062613471622900_ofag342-B7","doi-asserted-by":"crossref","first-page":"ofae120","DOI":"10.1093\/ofid\/ofae120","article-title":"Infectious diseases physician management of cryptococcal meningitis in North America-is single high-dose liposomal amphotericin B being used?","volume":"11","author":"Bahr","year":"2024","journal-title":"Open Forum Infect Dis"},{"key":"2026062613471622900_ofag342-B8","doi-asserted-by":"crossref","first-page":"e495","DOI":"10.1016\/S1473-3099(23)00731-4","article-title":"Global guideline for the diagnosis and management of cryptococcosis: an initiative of the ECMM and ISHAM in cooperation with the ASM","volume":"24","author":"Chang","year":"2024","journal-title":"Lancet Infect 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National Institute of Allergy and Infectious Diseases Mycoses Study Group and AIDS Clinical Trials Group","volume":"337","author":"van der Horst","year":"1997","journal-title":"N Engl J Med"},{"key":"2026062613471622900_ofag342-B10","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1056\/NEJMoa1710922","article-title":"Antifungal combinations for treatment of cryptococcal meningitis in Africa","volume":"378","author":"Molloy","year":"2018","journal-title":"N Engl J Med"},{"key":"2026062613471622900_ofag342-B11"},{"key":"2026062613471622900_ofag342-B12","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1056\/NEJMoa2111904","article-title":"Single-dose liposomal amphotericin B treatment for cryptococcal meningitis","volume":"386","author":"Jarvis","year":"2022","journal-title":"N Engl J Med"},{"key":"2026062613471622900_ofag342-B13","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1093\/cid\/ciac792","article-title":"How applicable is the single-dose AMBITION 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