{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T20:59:35Z","timestamp":1781729975190,"version":"3.54.5"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:00:00Z","timestamp":1780444800000},"content-version":"vor","delay-in-days":2,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["PJT-190227"],"award-info":[{"award-number":["PJT-190227"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"name":"McGill University Health Centre Foundation"},{"name":"McGill University Department of Medicine"},{"name":"Fonds de Recherche du Qu\u00e9bec\u2014Sant\u00e9","award":["#330287"],"award-info":[{"award-number":["#330287"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>We aimed to estimate the sensitivity of skin and blood\u2013based tuberculosis (TB) infection tests and assess variation in sensitivity by test type and population characteristics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a meta-analysis of studies involving individuals with microbiologically confirmed TB disease (surrogate reference standard) who underwent TB infection testing. Searches were performed across databases up to February 24, 2025. Data were extracted using a standardized form and pooled using random-effects meta-analysis. Primary analyses focused on tests performed before or during TB disease treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>From 103 031 records, 307 studies were included: 110 evaluated tuberculin skin testing (TST), 185 QuantiFERON (QFT), 107 T-SPOT.TB, 10 antigen-based skin tests, and 5 TB-IGRA. Sensitivity was consistently lower among people with HIV. Among populations without vs with HIV, respectively, TST \u22655 mm sensitivity was 80.3% (95% CI, 73.7%\u201385.5%) and 53.6% (95% CI, 41.5%\u201365.4%), TST \u226510 mm sensitivity was 75.1% (95% CI, 68.8%\u201380.5%) and 64.5% (95% CI, 36.8%\u201385.0%), antigen-based skin test sensitivity was 77.7% (95% CI, 69.7%\u201384%) and 61.3% (95% CI, 39.6%\u201379.3%), QFT sensitivity was 82.6% (95% CI, 80.7%\u201384.3%) and 66.5% (95% CI, 59.8%\u201372.6%), and T-SPOT.TB sensitivity was 88.2% (95% CI, 86.2%\u201390.0%) and 69% (95% CI, 56.6%\u201379.2%). TB-IGRA was only evaluated in populations without HIV (sensitivity, 85.4%; 95% CI, 81.3%\u201388.7%). Sensitivity in other populations targeted for TB infection testing generally fell between estimates among people with and without HIV. In comparative analyses, TST \u22655\u2005mm and TST \u226510\u2005mm had comparable sensitivity to QFT; however, T-SPOT.TB had superior sensitivity to both TST \u22655\u2005mm and QFT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>TB infection test sensitivity varies by test type and population. All tests showed reduced sensitivity in people with HIV. T-SPOT.TB demonstrated the highest sensitivity across populations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ofid\/ofag345","type":"journal-article","created":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T11:41:05Z","timestamp":1780141265000},"source":"Crossref","is-referenced-by-count":0,"title":["Sensitivity of Tuberculosis Infection Diagnostic Tests Among Different Populations: A Systematic Review and Meta-analysis"],"prefix":"10.1093","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-8627-5801","authenticated-orcid":false,"given":"Namrata","family":"Rana","sequence":"first","affiliation":[{"name":"Virtua Health College of Medicine & Life Sciences, Rowan University , Glassboro, New Jersey ,","place":["USA"]},{"name":"Respiratory Epidemiology and Clinical Research Unit, Research Institute of the McGill University Health Centre , Montreal, Quebec ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2771-0651","authenticated-orcid":false,"given":"Rapha\u00eblle","family":"Noseworthy","sequence":"additional","affiliation":[{"name":"Respiratory Epidemiology and Clinical Research Unit, Research Institute of the McGill University Health Centre , Montreal, Quebec ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elias","family":"Jabbour","sequence":"additional","affiliation":[{"name":"Respiratory Epidemiology and Clinical Research Unit, Research Institute of the McGill University Health Centre , Montreal, Quebec ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2916-938X","authenticated-orcid":false,"given":"Tessa","family":"Palmert","sequence":"additional","affiliation":[{"name":"Respiratory Epidemiology and Clinical Research Unit, Research Institute of the McGill University Health Centre , Montreal, Quebec ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mona","family":"Salah","sequence":"additional","affiliation":[{"name":"Respiratory Epidemiology and Clinical Research Unit, Research Institute of the McGill University Health Centre , Montreal, Quebec ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sammy D","family":"Robayo","sequence":"additional","affiliation":[{"name":"Respiratory Epidemiology and Clinical Research Unit, Research Institute of the McGill University Health Centre , Montreal, Quebec ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9521-5949","authenticated-orcid":false,"given":"Vaidehi","family":"Nafade","sequence":"additional","affiliation":[{"name":"Respiratory Epidemiology and Clinical Research Unit, Research Institute of the McGill University Health Centre , Montreal, Quebec ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0194-7397","authenticated-orcid":false,"given":"Victor Santana","family":"Santos","sequence":"additional","affiliation":[{"name":"Department of Medicine, Federal University of Sergipe , Lagarto ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathon R","family":"Campbell","sequence":"additional","affiliation":[{"name":"Respiratory Epidemiology and Clinical Research Unit, Research Institute of the McGill University Health Centre , Montreal, Quebec ,","place":["Canada"]},{"name":"Department of Medicine, Faculty of Medicine and Health Sciences, McGill University , Montreal, Quebec ,","place":["Canada"]},{"name":"McGill International TB Centre, Faculty of Medicine and Health Sciences, McGill University , Montreal, Quebec ,","place":["Canada"]},{"name":"Department of Global and Public Health, Faculty of Medicine and Health Sciences, McGill University , Montreal, Quebec ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,6,2]]},"reference":[{"key":"2026061716452620100_ofag345-B1","doi-asserted-by":"crossref","DOI":"10.54394\/CJQU6666","volume-title":"Global Tuberculosis Report: 2024","author":"World Health Organization","year":"2024"},{"key":"2026061716452620100_ofag345-B2","volume-title":"WHO Consolidated Guidelines on Tuberculosis. 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