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CTSA"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This study aimed to examine the prevalence of hepatitis B virus (HBV) in people with HIV (PWH) undergoing contemporary antiretroviral therapy and people without HIV and to understand the risk factors in people with HIV\/HBV coinfection. This retrospective cross-sectional study included 5238 participants with HIV or at risk for HIV acquisition across 13 US sites in the MACS\/WIHS Combined Cohort Study (Multicenter AIDS Cohort Study \/ Women Interagency HIV Study) between January 2018 and December 2024.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The primary outcome was the prevalence of HBV infection and HIV\/HBV coinfection. We defined a positive HBsAg (surface antigen) as chronic HBV infection, a negative HBsAg and positive anti-HBV core antibody as recovered infection, and a negative HBsAg and negative anti-HBV core antibody as never infection. The prevalence of chronic and recovered HBV infection was described in different risk groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In this cohort, the overall prevalence of chronic HBV was 2.4%, and HIV\/HBV coinfection was 3.0% among PWH. Current and prior HBV infection was more common in men, and the prevalence of prior HBV increased with age. As compared with the other 2 groups, PWH with chronic HBV infection had lower CD4+ T-cell counts (567 vs 651 and 689\u2005cells\/\u00b5L), CD4+ T-cell nadirs (210 vs 245 and 258\u2005cells\/\u00b5L), and HIV viral suppression rate (71.7% vs 82.3% and 83.7%). Among PWH who never had HBV infection, 40.6% lacked seroprotection against HBV.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>HBV is still prevalent in PWH. HBV coinfection was associated with lower CD4+ T-cell counts and viral suppression rate in PWH. The low seroprotection rate in those without HBV underscores the need for improved screening and immunization.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ofid\/ofag346","type":"journal-article","created":{"date-parts":[[2026,5,31]],"date-time":"2026-05-31T11:37:07Z","timestamp":1780227427000},"source":"Crossref","is-referenced-by-count":0,"title":["High Prevalence of Hepatitis B in People With HIV in the MWCCS, 2018\u20132024"],"prefix":"10.1093","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4046-9594","authenticated-orcid":false,"given":"Maria F","family":"Sanes Guevara","sequence":"first","affiliation":[{"name":"School of Medicine, University of Pittsburgh , Pittsburgh, Pennsylvania ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7973-1268","authenticated-orcid":false,"given":"Ken S","family":"Ho","sequence":"additional","affiliation":[{"name":"School of Medicine, University of 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