{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T11:40:05Z","timestamp":1788090005690,"version":"build-2803163510"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:00:00Z","timestamp":1781740800000},"content-version":"vor","delay-in-days":17,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Immune reconstitution inflammatory syndrome (IRIS) is a well-described complication following initiation of antiretroviral therapy (ART) in people with HIV. In this case report, we describe the complex clinical presentation of a 27-year-old ART-na\u00efve male with advanced HIV who developed Kaposi sarcoma-associated IRIS (KS-IRIS) with visceral involvement and pericardial effusion shortly after starting ART. We review known risk factors for KS-IRIS, its clinical manifestations including rare cardiac involvement and paradoxical worsening with steroid use, as well as current evidence for chemotherapeutic and antiviral treatment strategies.<\/jats:p>","DOI":"10.1093\/ofid\/ofag363","type":"journal-article","created":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T12:34:54Z","timestamp":1781613294000},"source":"Crossref","is-referenced-by-count":1,"title":["Kaposi Sarcoma-Associated Immune Reconstitution Inflammatory Syndrome (KS-IRIS) in Advanced HIV: Challenges in Managing Visceral Disease With Pericardial Involvement"],"prefix":"10.1093","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0634-1370","authenticated-orcid":false,"given":"Natalie A","family":"Sturd","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Nebraska Medical Center , Omaha, Nebraska ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0635-312X","authenticated-orcid":false,"given":"Nicole L","family":"Kusnik","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, University of Nebraska Medical Center , Omaha, Nebraska ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6760-0022","authenticated-orcid":false,"given":"Katerina","family":"Roma","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, University of Nebraska Medical Center , Omaha, Nebraska ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Hewlett","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, University of Nebraska Medical Center , Omaha, Nebraska ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2130-2505","authenticated-orcid":false,"given":"Sara H","family":"Bares","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, University of Nebraska Medical Center , Omaha, Nebraska ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4971-1490","authenticated-orcid":false,"given":"Jennifer M","family":"Davis","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, University of Nebraska Medical Center , Omaha, Nebraska ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,6,18]]},"reference":[{"key":"2026062202515676500_ofag363-B1","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S1473-3099(10)70026-8","article-title":"Immune reconstitution inflammatory syndrome in patients starting antiretroviral therapy for HIV infection: a systematic review and meta-analysis","volume":"10","author":"M\u00fcller","year":"2010","journal-title":"Lancet Infect Dis"},{"key":"2026062202515676500_ofag363-B2","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0011416","article-title":"Risk factor analyses for immune reconstitution inflammatory syndrome in a randomized study of early vs Deferred ART during an opportunistic infection","volume":"5","author":"Grant","year":"2010","journal-title":"PLoS One"},{"key":"2026062202515676500_ofag363-B3","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1097\/QAD.0b013e3283511e91","article-title":"Immune reconstitution inflammatory syndrome: incidence and implications for mortality","volume":"26","author":"Novak","year":"2012","journal-title":"AIDS"},{"key":"2026062202515676500_ofag363-B4","doi-asserted-by":"crossref","first-page":"49","DOI":"10.2147\/HIV.S42328","article-title":"Immune reconstitution inflammatory syndrome in HIV-infected patients","volume":"7","author":"Wilkinson","year":"2015","journal-title":"HIV\/AIDS \u2013 Res. 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