{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T09:58:07Z","timestamp":1785491887123,"version":"3.56.0"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T00:00:00Z","timestamp":1782000000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Prosthetic joint infection (PJI) represents an important complication of total joint arthroplasty, affecting approximately 2% of patients. However, considerable heterogeneity in outcome definitions renders cross-study and clinical comparisons challenging.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a meta-epidemiological study and systematic review of cohort studies and randomized controlled trial (RCTs) reporting clear definitions of PJI outcomes. Relevant data regarding outcome definitions of treatment success or failure were extracted and categorized into 7 outcome domains: clinical signs and symptoms, imaging, microbiology, mortality, antibiotics-related, surgical-related, and histology. A network plot was generated to visualize domains combinations. Data on patient-reported outcome measures (PROMs) were also collected. Based on these results, we finally proposed a working definition of PJI core outcome set.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The literature search identified 7585 references, leading to 461 studies. The majority were retrospective (416\/461, 90.2%), with limited representation of prospective studies (37\/461, 8.0%) and RCTs (8\/461, 1.7%). Outcome reporting was highly heterogeneous, with the clinical criterion being the most frequently used domain, combined with microbiological, surgical, and mortality-related outcomes. In contrast, histopathological, imaging, and antibiotic-related criteria were rarely reported. Thirty-six PROMs were included in only 111 (24.1%) studies, most commonly the Knee Society Score (26%) and Harris Hip Score (23%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We showed substantial heterogeneity in PJI outcome definitions, with inconsistent reporting across key domains, limiting comparability and evidence synthesis. Standardized, consensus-based outcomes incorporating patient-reported and antibiotic-related measures are needed, and the proposed core outcome set may support harmonized research and clinical practice aligned with the new PJI definition.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ofid\/ofag364","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T11:20:02Z","timestamp":1781695202000},"source":"Crossref","is-referenced-by-count":0,"title":["Defining Success and Failure In Prosthetic Joint Infections: A Meta-epidemiologic Study Toward A Core Outcome Set"],"prefix":"10.1093","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0125-9551","authenticated-orcid":false,"given":"Francesco","family":"Petri","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, \u201cLuigi Sacco\u201d University Hospital, ASST FBF Sacco , Milan ,","place":["Italy"]},{"name":"Division of Public Health, Infectious Diseases and Occupational Medicine, Department of Medicine, Mayo Clinic College of Medicine and Science, Mayo Clinic , Rochester, Minnesota ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7885-6691","authenticated-orcid":false,"given":"Seyed Mohammad Amin","family":"Alavi","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences , Ahvaz ,","place":["Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3607-1847","authenticated-orcid":false,"given":"Cosmin Lucian","family":"Ciubotariu","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, \u201cLuigi Sacco\u201d University Hospital, ASST FBF Sacco , Milan ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8120-1853","authenticated-orcid":false,"given":"Matteo","family":"Passerini","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, \u201cLuigi Sacco\u201d University Hospital, ASST FBF Sacco , Milan ,","place":["Italy"]},{"name":"Division of Public Health, Infectious Diseases and Occupational Medicine, Department of Medicine, Mayo Clinic College of Medicine and Science, Mayo Clinic , Rochester, Minnesota ,","place":["USA"]},{"name":"Department of Pathophysiology and Transplantation, University of Milan , Milan ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5796-671X","authenticated-orcid":false,"given":"Fabio","family":"Borgonovo","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, \u201cLuigi Sacco\u201d University Hospital, ASST FBF Sacco , Milan ,","place":["Italy"]},{"name":"Division of Public Health, Infectious Diseases and Occupational Medicine, Department of Medicine, Mayo Clinic College of Medicine and Science, Mayo Clinic , Rochester, Minnesota ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9389-0628","authenticated-orcid":false,"given":"Takahiro","family":"Matsuo","sequence":"additional","affiliation":[{"name":"Division of Public Health, Infectious Diseases and Occupational Medicine, Department of Medicine, Mayo Clinic College of Medicine and Science, Mayo Clinic , Rochester, Minnesota ,","place":["USA"]},{"name":"Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M.D. Anderson Cancer Center , Houston, Texas ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4249-5940","authenticated-orcid":false,"given":"Haseeb","family":"Khawar","sequence":"additional","affiliation":[{"name":"University Hospitals Nottingham NHS Trust, Trauma and Orthopedics , Nottingham ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9264-537X","authenticated-orcid":false,"given":"Ben A","family":"Marson","sequence":"additional","affiliation":[{"name":"University Hospitals Nottingham NHS Trust, Trauma and Orthopedics , Nottingham ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil","family":"Jagtiani","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Kaiser Permanente Southern California , Fontana, California ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5502-5975","authenticated-orcid":false,"given":"Mohammad Hassan","family":"Murad","sequence":"additional","affiliation":[{"name":"Division of Public Health, Infectious Diseases and Occupational Medicine, Department of Medicine, Mayo Clinic College of Medicine and Science, Mayo Clinic , Rochester, Minnesota ,","place":["USA"]},{"name":"Evidence-based Practice Center, Mayo Clinic , Rochester, Minnesota ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6587-4794","authenticated-orcid":false,"given":"Andrea","family":"Gori","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, \u201cLuigi Sacco\u201d University Hospital, ASST FBF Sacco , Milan ,","place":["Italy"]},{"name":"Department of Biomedical and Clinical Sciences, University of Milan , Milan ,","place":["Italy"]},{"name":"Centre for Multidisciplinary Research in Health Science (MACH) , Milan ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9775-7082","authenticated-orcid":false,"given":"Aaron J","family":"Tande","sequence":"additional","affiliation":[{"name":"Division of Public Health, Infectious Diseases and Occupational Medicine, Department of Medicine, Mayo Clinic College of Medicine and Science, Mayo Clinic , Rochester, Minnesota ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elie F","family":"Berbari","sequence":"additional","affiliation":[{"name":"Division of Public Health, Infectious Diseases and Occupational Medicine, Department of Medicine, Mayo Clinic College of Medicine and Science, Mayo Clinic , Rochester, Minnesota 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