{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T09:58:05Z","timestamp":1785491885284,"version":"3.56.0"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Despite durable viral suppression with antiretroviral therapy (ART), non-AIDS comorbidities remain frequent in aging people with HIV (PWH). Cerebral small-vessel disease (CSVD), a major contributor to stroke and cognitive decline, is up to twice as prevalent in middle-aged ART-treated PWH. Mechanisms underlying this excess risk remain unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aims to identify inflammatory, viral, renal, and retinal vascular factors independently associated with CSVD in virologically controlled PWH.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The case\u2013control MicroBREAK-2 study (NCT02210130), nested in the PWH group of the MicroBREAK-1 study, included 80 ART-treated (\u22655 years) PWH aged \u226550 years with MRI-defined CSVD and 80 matched CSVD-free controls (age \u00b1 5 years, sex, year of HIV diagnosis \u00b1 5 years). Participants underwent brain MRI, renal, carotid, and orbital color Doppler ultrasonography, and comprehensive ophthalmologic assessment. Circulating inflammatory and coagulation biomarkers, Epstein\u2013Barr virus plasma load, and antiretroviral exposure were measured. Independent associations were identified using conditional logistic regression with LASSO selection and bootstrap resampling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Hypertension was the strongest independent correlate of CSVD (OR 4.92, 95% CI 1.23\u201319.62; P = .02). Markers of persistent inflammatory and coagulative activity were also independently linked to CSVD, including higher white blood cell count (OR 1.58; 1.17\u20132.14; P = .003) and elevated D-dimer levels (OR 1.52; 1.09\u20132.12; P = .01). Increased intraocular pressure was independently related to CSVD (OR 6.37; 1.38\u201329.4; P = .02). In contrast, HIV-specific parameters showed no independent relationship with CSVD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In virologically suppressed PWH, CSVD is primarily associated with hypertension and persistent low-grade inflammation rather than HIV-specific factors, underscoring the need for aggressive cardiovascular risk management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ofid\/ofag382","type":"journal-article","created":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T11:49:17Z","timestamp":1782388157000},"source":"Crossref","is-referenced-by-count":0,"title":["Predictors of Cerebral Small-Vessel Disease in Middle-Aged, Virologically Controlled People Living With HIV"],"prefix":"10.1093","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7566-0175","authenticated-orcid":false,"given":"Antoine","family":"Moulignier","sequence":"first","affiliation":[{"name":"F\u00e9d\u00e9ration de Neurologie, H\u00f4pital Fondation Adolphe de Rothschild , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9dric","family":"Lamirel","sequence":"additional","affiliation":[{"name":"Institut du Nerf Optique et du Glaucome (INOG), H\u00f4pital Fondation Adolphe de Rothschild , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arbnor","family":"Zenuni","sequence":"additional","affiliation":[{"name":"Institut Pierre-Louis d'Epid\u00e9miologie et de Sant\u00e9 Publique (IPLESP), Sorbonne Universit\u00e9, INSERM , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Koskas","sequence":"additional","affiliation":[{"name":"Service d\u2019Imagerie M\u00e9dicale, H\u00f4pital Fondation Adolphe de Rothschild , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corinne","family":"Amiel","sequence":"additional","affiliation":[{"name":"Service de Virologie, APHP, H\u00f4pital Saint Antoine , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Tubiana","sequence":"additional","affiliation":[{"name":"Service de Maladies Infectieuses et Tropicales, APHP, H\u00f4pital Piti\u00e9\u2013Salp\u00eatri\u00e8re , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Katlama","sequence":"additional","affiliation":[{"name":"Service de Maladies Infectieuses et Tropicales, APHP, H\u00f4pital Piti\u00e9\u2013Salp\u00eatri\u00e8re , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soraya","family":"Fellahi","sequence":"additional","affiliation":[{"name":"INSERM UMR_S938, Centre de Recherche Saint-Antoine, Institut Hospitalo-Universitaire de Cardio-M\u00e9tabolisme et Nutrition (ICAN), Sorbonne Universit\u00e9 , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Philippe","family":"Bastard","sequence":"additional","affiliation":[{"name":"INSERM UMR_S938, Centre de Recherche Saint-Antoine, Institut Hospitalo-Universitaire de Cardio-M\u00e9tabolisme et Nutrition (ICAN), Sorbonne Universit\u00e9 , Paris ,","place":["France"]},{"name":"D\u00e9partement de Biochimie et de Pharmacologie, INSERM UMR U955 et Universit\u00e9 Paris Est (UPEC), APHP, H\u00f4pital Henri Mondor , Cr\u00e9teil ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline","family":"Capeau","sequence":"additional","affiliation":[{"name":"INSERM UMR_S938, Centre de Recherche Saint-Antoine, Institut Hospitalo-Universitaire de Cardio-M\u00e9tabolisme et Nutrition (ICAN), Sorbonne Universit\u00e9 , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0765-0869","authenticated-orcid":false,"given":"Dominique","family":"Costagliola","sequence":"additional","affiliation":[{"name":"Institut Pierre-Louis d'Epid\u00e9miologie et de Sant\u00e9 Publique (IPLESP), Sorbonne Universit\u00e9, INSERM , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Am\u00e9lie","family":"Yavchitz","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Recherche Clinique, H\u00f4pital Fondation Adolphe de Rothschild , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Augustin","family":"Lecler","sequence":"additional","affiliation":[{"name":"Service d\u2019Imagerie M\u00e9dicale, H\u00f4pital Fondation Adolphe de Rothschild , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lambert","family":"Assoumou","sequence":"additional","affiliation":[{"name":"Institut Pierre-Louis d'Epid\u00e9miologie et de Sant\u00e9 Publique (IPLESP), Sorbonne Universit\u00e9, INSERM , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the Microvascular Brain REtina And Kidney (MicroBREAK) Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Moulignier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Moulignier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Amiel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Assoumou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Canestri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Cochereau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Capeau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Costagliola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O","family":"Godin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P -M","family":"Girard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Katlama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Lamirel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F -X","family":"Lescure","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Marchand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Mazighi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Obadia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Paques","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Pialoux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Plaisier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Tubiana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Valin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Yazdanpanah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Yeni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Moulignier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Abrivard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A -S","family":"Alonso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Cochereau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Koskas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Lamirel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Lopes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Mazighi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Obadia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Roux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J -C","family":"Sadik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Salomon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Savatovsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Vasseur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F -X","family":"Lescure","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Chansombat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Landman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Phung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Rahli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Yazdanpanah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Yeni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Katlama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Lenclume","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Tubiana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Valantin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P -M","family":"Girard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J -L","family":"Meynard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Sebire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Valin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Pialoux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Adda Li\u00e9vin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Amiel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J -P","family":"Bastard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Canestri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Capeau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Fellahi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M -G","family":"Lebrette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Plaisier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Thibaut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Costagliola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Assoumou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Dos Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O","family":"Godin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Marchand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Girard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J -P","family":"Vincensini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,6,29]]},"reference":[{"key":"2026073105063505100_ofag382-B1","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/S1474-4422(23)00131-X","article-title":"Neuroimaging standards for research into small vessel disease\u2014advances since 2013","volume":"22","author":"Duering","year":"2023","journal-title":"Lancet Neurol"},{"key":"2026073105063505100_ofag382-B2","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1177\/1747493015607485","article-title":"The concept of sporadic cerebral small vessel disease: a road map on key definitions and current concepts","volume":"11","author":"Charidimou","year":"2016","journal-title":"Int J Stroke"},{"key":"2026073105063505100_ofag382-B3","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/S1474-4422(19)30079-1","article-title":"Small vessel disease: mechanisms and clinical implications","volume":"18","author":"Wardlaw","year":"2019","journal-title":"Lancet Neurol"},{"key":"2026073105063505100_ofag382-B4","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/S1474-4422(13)70060-7","article-title":"Mechanisms of sporadic cerebral small vessel disease: insights from neuroimaging","volume":"12","author":"Wardlaw","year":"2013","journal-title":"Lancet Neurol"},{"key":"2026073105063505100_ofag382-B5","doi-asserted-by":"crossref","first-page":"1594891","DOI":"10.3389\/fimmu.2025.1594891","article-title":"Review of the mechanism of infection induced cerebral small vessel disease","volume":"16","author":"Song","year":"2025","journal-title":"Front Immunol"},{"key":"2026073105063505100_ofag382-B6","doi-asserted-by":"crossref","first-page":"100916","DOI":"10.1016\/j.arr.2019.100916","article-title":"Inflammation and cerebral small vessel disease: a systematic review","volume":"53","author":"Low","year":"2019","journal-title":"Ageing Res Rev"},{"key":"2026073105063505100_ofag382-B7","doi-asserted-by":"crossref","first-page":"67","DOI":"10.3389\/fimmu.2018.00067","article-title":"Emerging role of immunity in cerebral small vessel disease","volume":"9","author":"Fu","year":"2018","journal-title":"Front Immunol"},{"key":"2026073105063505100_ofag382-B8","doi-asserted-by":"crossref","first-page":"S157","DOI":"10.1097\/QAD.0000000000001384","article-title":"Cardiovascular health in an aging HIV population","volume":"31","author":"Boccara","year":"2017","journal-title":"AIDS"},{"key":"2026073105063505100_ofag382-B9","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0210253","article-title":"Trends in the risk of myocardial infarction among HIV-1-infected individuals relative to the general population in France: impact of gender and immune status. Landay A, editor","volume":"14","author":"Bald\u00e9","year":"2019","journal-title":"PLoS One"},{"key":"2026073105063505100_ofag382-B10","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1093\/cid\/cix1075","article-title":"Silent cerebral small-vessel disease twice as prevalent in middle-aged well-controlled cart-treated HIV-infected individuals than HIV-uninfected individuals","volume":"66","author":"Moulignier","year":"2018","journal-title":"Clin Infect Dis"},{"key":"2026073105063505100_ofag382-B11","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1097\/QAD.0000000000000945","article-title":"White matter structure alterations in HIV-1-infected men with sustained suppression of viraemia on treatment","volume":"30","author":"Su","year":"2016","journal-title":"AIDS"},{"key":"2026073105063505100_ofag382-B12","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1586\/ern.10.204","article-title":"Reno-cerebrovascular disease: linking the nephron and neuron","volume":"11","author":"Lee","year":"2011","journal-title":"Expert Rev Neurother"},{"key":"2026073105063505100_ofag382-B13","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/j.ncl.2010.03.009","article-title":"Vascular neuro-ophthalmology","volume":"28","author":"Lamirel","year":"2010","journal-title":"Neurol Clin"},{"key":"2026073105063505100_ofag382-B14","article-title":"Absence of peripapillary retinal nerve-fiber\u2013layer thinning in combined antiretroviral therapy-treated, well-sustained aviremic persons living with HIV. Lewin AS, editor","volume":"15","author":"Lamirel","year":"2020","journal-title":"PLoS One"},{"key":"2026073105063505100_ofag382-B15","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1007\/s00415-019-09674-6","article-title":"Microalbuminuria: a sentinel of neurocognitive impairment in HIV-infected individuals?","volume":"267","author":"Moulignier","year":"2020","journal-title":"J Neurol"},{"key":"2026073105063505100_ofag382-B16","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/s11065-019-09412-9","article-title":"Montreal Cognitive Assessment (MoCA) for HIV-associated neurocognitive disorders","volume":"29","author":"Rosca","year":"2019","journal-title":"Neuropsychol Rev"},{"key":"2026073105063505100_ofag382-B17","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1002\/jcu.10169","article-title":"Color Doppler imaging of orbital vessels: personal experience and literature review","volume":"31","author":"Tranquart","year":"2003","journal-title":"J Clin Ultrasound"},{"key":"2026073105063505100_ofag382-B18","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1097\/HJH.0b013e328365b29c","article-title":"Ultrasound Doppler renal resistive index: a useful tool for the management of the hypertensive patient","volume":"32","author":"Viazzi","year":"2014","journal-title":"J Hypertens"},{"key":"2026073105063505100_ofag382-B19","first-page":"191","volume-title":"Hypertension: from basic research to clinical practice","author":"Boddi","year":"2017"},{"key":"2026073105063505100_ofag382-B20","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1159\/000343145","article-title":"Mannheim carotid intima-media thickness and plaque consensus (2004\u20132006\u20132011)","volume":"34","author":"Touboul","year":"2012","journal-title":"Cerebrovasc Dis"},{"key":"2026073105063505100_ofag382-B21","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1093\/jac\/dkv036","article-title":"Increased systemic immune activation and inflammatory profile of long-term HIV-infected ART-controlled patients is related to personal factors, but not to markers of HIV infection severity","volume":"70","author":"Bastard","year":"2015","journal-title":"J Antimicrob Chemother"},{"key":"2026073105063505100_ofag382-B22","first-page":"8371","article-title":"Diagnostic value of plasma D-dimer and serum lipoprotein phospholipase A2 in patients with cerebral small vessel disease and their association with severity of the disease","volume":"14","author":"Kong","year":"2022","journal-title":"Am J Transl Res"},{"key":"2026073105063505100_ofag382-B23","doi-asserted-by":"crossref","first-page":"1331733","DOI":"10.3389\/fneur.2024.1331733","article-title":"Association of coagulation markers with the severity of white matter hyperintensities in cerebral small vessel disease","volume":"15","author":"Xu","year":"2024","journal-title":"Front Neurol"},{"key":"2026073105063505100_ofag382-B24","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1161\/STROKEAHA.115.011035","article-title":"Plasma d -dimer and incident ischemic stroke and coronary heart disease: the atherosclerosis risk in communities study","volume":"47","author":"Folsom","year":"2016","journal-title":"Stroke"},{"key":"2026073105063505100_ofag382-B25","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.114.000844","article-title":"Severity of cardiovascular disease outcomes among patients with HIV is related to markers of inflammation and coagulation","volume":"3","author":"Nordell","year":"2014","journal-title":"J Am Heart Assoc"},{"key":"2026073105063505100_ofag382-B26","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1097\/QAD.0b013e32833ad914","article-title":"Traditional risk factors and D-dimer predict incident cardiovascular disease events in chronic HIV infection","volume":"24","author":"Ford","year":"2010","journal-title":"AIDS Lond Engl"},{"key":"2026073105063505100_ofag382-B27","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.amjcard.2023.06.119","article-title":"The prognostic significance of leukocyte count on all-cause and cardiovascular disease mortality: a systematic review and meta-analysis","volume":"203","author":"Park","year":"2023","journal-title":"Am J Cardiol"},{"key":"2026073105063505100_ofag382-B28","first-page":"101","article-title":"The epidemiology, mechanisms, diagnosis and treatment of cardiovascular disease in adult patients with HIV","volume":"13","author":"Henning","year":"2023","journal-title":"Am J Cardiovasc Dis"},{"key":"2026073105063505100_ofag382-B29","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1111\/ceo.14043","article-title":"Normal-tension glaucoma: current concepts and approaches-A review","volume":"50","author":"Leung","year":"2022","journal-title":"Clin Exp Ophthalmol"},{"key":"2026073105063505100_ofag382-B30","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1093\/cid\/ciw498","article-title":"Switching to raltegravir from a virologically effective boosted protease inhibitor regimen: a comparative effectiveness analysis from the French Hospital Database on HIV (FHDH-ANRS CO4)","volume":"63","author":"Potard","year":"2016","journal-title":"Clin Infect Dis"},{"key":"2026073105063505100_ofag382-B31","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1093\/brain\/awac465","article-title":"Twelve-year neurocognitive decline in HIV is associated with comorbidities, not age: a CHARTER study","volume":"146","author":"Heaton","year":"2023","journal-title":"Brain"},{"key":"2026073105063505100_ofag382-B32","doi-asserted-by":"crossref","first-page":"ofae229","DOI":"10.1093\/ofid\/ofae229","article-title":"One-year frailty transitions among persons with HIV aged 70 years or older on antiretroviral treatment","volume":"11","author":"Achour","year":"2024","journal-title":"Open Forum Infect Dis"},{"key":"2026073105063505100_ofag382-B33","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1097\/QAD.0000000000003403","article-title":"Prevalence and risk factors of frailty among adults living with HIV aged 70 years or older","volume":"37","author":"Allavena","year":"2023","journal-title":"AIDS"},{"key":"2026073105063505100_ofag382-B34","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1177\/1358863X18789767","article-title":"Vascular disease and aging in HIV: time to extend the treatment cascade","volume":"23","author":"Longenecker","year":"2018","journal-title":"Vasc Med"},{"key":"2026073105063505100_ofag382-B35","doi-asserted-by":"crossref","first-page":"ofu076","DOI":"10.1093\/ofid\/ofu076","article-title":"Aspirin use for primary and secondary prevention in human immunodeficiency virus (HIV)-infected and HIV-uninfected patients","volume":"1","author":"Suchindran","year":"2014","journal-title":"Open Forum Infect Dis"},{"key":"2026073105063505100_ofag382-B36","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1002\/acn3.52008","article-title":"First-ever acute ischemic strokes in HIV-infected persons: a case-control study from stroke units","volume":"11","author":"Stammler","year":"2024","journal-title":"Ann Clin Transl Neurol"},{"key":"2026073105063505100_ofag382-B37","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1080\/09540121.2016.1200712","article-title":"Impact of age on care pathways of people living with HIV followed up in hospital","volume":"29","author":"Jacomet","year":"2017","journal-title":"AIDS Care"}],"container-title":["Open Forum Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ofid\/advance-article-pdf\/doi\/10.1093\/ofid\/ofag382\/68642106\/ofag382.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ofid\/article-pdf\/13\/7\/ofag382\/68642106\/ofag382.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ofid\/article-pdf\/13\/7\/ofag382\/68642106\/ofag382.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T09:06:46Z","timestamp":1785488806000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ofid\/article\/doi\/10.1093\/ofid\/ofag382\/8721344"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,29]]},"references-count":37,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7,1]]}},"URL":"https:\/\/doi.org\/10.1093\/ofid\/ofag382","relation":{},"ISSN":["2328-8957"],"issn-type":[{"value":"2328-8957","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,7]]},"published":{"date-parts":[[2026,6,29]]},"article-number":"ofag382"}}