{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T20:04:12Z","timestamp":1783973052177,"version":"3.55.0"},"reference-count":61,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:00:00Z","timestamp":1783900800000},"content-version":"vor","delay-in-days":12,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Fondo de Investigaci\u00f3n Sanitaria"},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI20\/00575"],"award-info":[{"award-number":["PI20\/00575"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Union","doi-asserted-by":"publisher","award":["FI21\/00314"],"award-info":[{"award-number":["FI21\/00314"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100003760","name":"FIS","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100003760","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Universit\u00e0 di Genova","award":["737 del 25\/06\/2021"],"award-info":[{"award-number":["737 del 25\/06\/2021"]}]},{"name":"Fondo per la promozione e lo sviluppo delle politiche del programma Nazionale per la ricerca"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This study was conducted to investigate the diagnostic value of fungal biomarker differentials and T2Candida polymerase chain reaction (PCR) from catheter and peripheral blood samples and to re-evaluate classical conservative methods, such as differential time to positivity of blood cultures (BCs), for the early identification of catheter-related candidemia (CRC) before catheter removal.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective study was conducted (March 2023\u2013April 2025) in 2 tertiary hospitals in Spain and Italy. Adults (aged \u226518 years) with candidemia and a central venous catheter in place at diagnosis were included, provided catheter removal occurred within 48\u2005hours of index BC positivity. CRC was defined in patients with candidemia who showed 1 or 2 of the following criteria in the catheter tip: (1) \u2265 15 CFU\/plate (Maki technique) or \u2265 1000 CFU\/mL (sonication) and (2) any Candida growth on the catheter tip. Blood samples were collected from peripheral veins and catheter lumens to compare the differentials of 1,3-\u03b2-D-glucan (BDG), Candida albicans germ tube antibodies, mannan antigen, antimannan antibody, and T2Candida PCR results. Diagnostic metrics were calculated for each test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 179 episodes of candidemia reviewed, 28 (15.6%) met the inclusion criteria (13 in Spain, 15 in Italy). CRC was confirmed in 11 patients (39.3%) using criterion 1 and in 15 patients (53.6%) using criterion 2. BDG differentials (any difference) demonstrated the highest diagnostic accuracy as follows: sensitivity 81.82%, specificity 82.35%, positive predictive value 75.00%, negative predictive value 87.50%, and overall accuracy 82.14% (criterion 1). However, stricter BDG thresholds (\u226520 or \u226530\u2005pg\/mL) and the application of criterion 2 reduced the sensitivity. Other biomarkers and T2Candida PCR demonstrated low sensitivity (0%\u201340%) and variable specificity (25%\u2013100%), with overall accuracies of &amp;lt;64%. Differential time to positivity of BCs yielded a sensitivity of 72.73% and a specificity of 52.94%, with limited accuracy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>None of the investigated methods achieved sufficient accuracy to diagnose CRC without catheter removal. Despite the limited sample size, this study emphasizes the limitations of current diagnostic approaches and the need for novel tools for reliable noninvasive identification of CRC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ofid\/ofag411","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T11:53:15Z","timestamp":1783684395000},"source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of Quantitative Differences of Classic Methods, Fungal Biomarkers, and T2Candida for Assessing the Central Venous Catheter Origin of Candidemia"],"prefix":"10.1093","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7226-8212","authenticated-orcid":false,"given":"Ana","family":"Soriano-Mart\u00edn","sequence":"first","affiliation":[{"name":"Clinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Mara\u00f1\u00f3n , Madrid ,","place":["Spain"]},{"name":"Instituto de Investigaci\u00f3n Sanitaria Hospital Gregorio Mara\u00f1\u00f3n (IiSGM) , Madrid ,","place":["Spain"]},{"name":"CIBER Enfermedades Respiratorias-CIBERES (CIBERES CB06\/06\/0058) , Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Vena","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, Policlinico San Martino Hospital\u2014IRCCS , Genoa ,","place":["Italy"]},{"name":"Department of Health Sciences (DISSAL), University of Genoa , Genoa ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Jes\u00fas","family":"P\u00e9rez-Granda","sequence":"additional","affiliation":[{"name":"Clinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Mara\u00f1\u00f3n , Madrid ,","place":["Spain"]},{"name":"Instituto de Investigaci\u00f3n Sanitaria Hospital Gregorio Mara\u00f1\u00f3n (IiSGM) , Madrid ,","place":["Spain"]},{"name":"CIBER Enfermedades 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