{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T20:04:25Z","timestamp":1783973065542,"version":"3.55.0"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T00:00:00Z","timestamp":1783123200000},"content-version":"vor","delay-in-days":3,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"International Society of Nephrology's Sister Renal Centers Program"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Data on the epidemiology of acute kidney injury (AKI) in adults hospitalized with Lassa fever is limited. We investigated the rates and predictors of AKI and in-hospital mortality at a National Treatment Centre in Southwest Nigeria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study included 482 adults with RT-PCR-confirmed Lassa fever admitted to the Federal Medical Centre, Owo, Ondo State, Nigeria, from January 2019 to December 2024. Predictors of AKI and in-hospital mortality were identified by multivariable logistic regression and Cox proportional hazards regression analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Acute kidney injury prevalence was 21% (95% CI, 17.4%\u201324.9%). Overall, 48 patients (10.1%) died: 33 (32.7%) with AKI and 15 (4.0%) without AKI (OR 11.647; 95% CI, 6.001\u201322.604; P &amp;lt; .001). Independent predictors of AKI included male sex (P &amp;lt; .001), bleeding abnormalities (P = .044), diabetes (P = .029), elevated white blood cell count (P = .005), increased neutrophil count (P = .003), and elevated aspartate transaminase (P = .017). Predictors of in-hospital mortality were AKI (P = .033), oliguria (P = .045), mean arterial blood pressure (P = .001), hematuria (P = .015), and elevated monocyte count (P = .022). Kaplan\u2013Meier analysis demonstrated significantly poorer survival in patients with AKI versus those without (mean survival 19.0 vs 29.7 days; P \u2264 .001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Acute kidney injury complicates approximately one-fifth of RT-PCR-confirmed Lassa fever hospitalizations and is associated with an 11-fold increase in mortality. Male sex, bleeding, diabetes, leukocytosis, and elevated aspartate transaminase independently predict AKI, while oliguria, hematuria, blood pressure, and monocyte count predict death.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ofid\/ofag412","type":"journal-article","created":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T11:37:59Z","timestamp":1782992279000},"source":"Crossref","is-referenced-by-count":0,"title":["Predictors of Acute Kidney Injury and In-Hospital Mortality in Patients With RT-PCR Confirmed Lassa Fever in Southwest Nigeria"],"prefix":"10.1093","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9429-4000","authenticated-orcid":false,"given":"Olalekan E","family":"Ojo","sequence":"first","affiliation":[{"name":"Department of Medicine, Federal Medical Centre , Owo, Ondo State ,","place":["Nigeria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muzamil O","family":"Hassan","sequence":"additional","affiliation":[{"name":"Department of Medicine, Obafemi Awolowo University , Ile Ife, Osun State ,","place":["Nigeria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6576-9596","authenticated-orcid":false,"given":"Olubukola A","family":"Ojo","sequence":"additional","affiliation":[{"name":"Department of Medicine, Federal Medical Centre , Owo, Ondo State ,","place":["Nigeria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adetumi A","family":"Subulade","sequence":"additional","affiliation":[{"name":"Department of Community Medicine, Federal Medical Centre , Owo, Ondo State ,","place":["Nigeria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6375-5247","authenticated-orcid":false,"given":"Isaac","family":"Ihinmikaye","sequence":"additional","affiliation":[{"name":"Department of Community Medicine, Federal Medical Centre , Owo, Ondo State ,","place":["Nigeria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oyebimpe O","family":"Oyegunle","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Services, Federal Medical Centre , Owo, Ondo State ,","place":["Nigeria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olufunke B","family":"Gbenga-Ayeni","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, Federal Medical Centre , Owo, Ondo State ,","place":["Nigeria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olufemi A","family":"Ayodeji","sequence":"additional","affiliation":[{"name":"Department of Community Medicine, Federal Medical Centre , Owo, Ondo State ,","place":["Nigeria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liasu A","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Office of the Vice Chancellor, Federal University of Medical Sciences , Abeokuta ,","place":["Nigeria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatiu A","family":"Arogundade","sequence":"additional","affiliation":[{"name":"Department of Medicine, Obafemi Awolowo University Teaching Hospitals Complex , Ile-Ife ,","place":["Nigeria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3357-6949","authenticated-orcid":false,"given":"Rasheed A","family":"Balogun","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, University of Virginia , Charlottesville, Virginia ,","place":["USA"]},{"name":"Department of Pathology, University of Virginia , Charlottesville, Virginia ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,7,4]]},"reference":[{"key":"2026071315070129400_ofag412-B1","first-page":"1","article-title":"KDIGO clinical practice guidelines for acute kidney 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