{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T07:28:12Z","timestamp":1786433292387,"version":"build-2736575974"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T00:00:00Z","timestamp":1786406400000},"content-version":"vor","delay-in-days":10,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI068634"],"award-info":[{"award-number":["AI068634"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI068636"],"award-info":[{"award-number":["AI068636"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI106701"],"award-info":[{"award-number":["AI106701"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI069494"],"award-info":[{"award-number":["AI069494"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["K24AG082527"],"award-info":[{"award-number":["K24AG082527"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Potential harms of preventable\/modifiable use of substances, such as cannabis, among aging people with HIV (PWH) are unclear. We characterized longitudinal associations between current cannabis use and subsequent fall risk among aging PWH.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>Participants in the Advancing Clinical Therapeutics Globally (ACTG) A5322 study self-reported current cannabis use and any fall(s) annually and semiannually, respectively. Generalized linear models and inverse probability weighting were used to assess associations between cannabis use and subsequent fall risk, adjusting for baseline covariates (age, sex assigned at birth, and race\/ethnicity), time-varying confounders, and study attrition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 957 participants (median age, 51 years), 18.2% reported current cannabis use at baseline; 18.6% reported falling in the first year of the longitudinal study. Current cannabis use was associated with moderate risk of any falls in the following year in baseline covariate-adjusted analysis (risk ratio [RR], 1.27 95% CI, 1.02, 1.57; P = .029), but not in analyses additionally adjusted for fall history, nonprescribed psychoactive substance use, psychotropic and analgesic medication use, heavy alcohol use, peripheral neuropathy, and cigarette smoking status (adjusted RR, 1.11 [95% CI, .83, 1.49]; P = .49). Cigarette smoking status was the main variable that attenuated the association between falls and cannabis use.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Among aging PWH, the association between current cannabis use and fall risk was primarily confounded by cigarette smoking status. Future studies should incorporate more granular cannabis use data on falls risk, including cannabis composition or strain and dose.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ofid\/ofag417","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T11:47:20Z","timestamp":1785930440000},"source":"Crossref","is-referenced-by-count":0,"title":["Association of Cannabis Use With Risk of Subsequent Falls Among Adults Aging With HIV"],"prefix":"10.1093","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0079-2306","authenticated-orcid":false,"given":"Jennifer A","family":"Manuzak","sequence":"first","affiliation":[{"name":"Division of Immunology, Tulane National Biomedical Research Center , Covington, Louisiana ,","place":["USA"]},{"name":"Department of Microbiology and Immunology, Tulane University School of Medicine , New Orleans, Louisiana ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5014-8092","authenticated-orcid":false,"given":"Janeway","family":"Granche","sequence":"additional","affiliation":[{"name":"Center for Biostatistics in AIDS Research (CBAR), Harvard T.H. Chan School of Public Health , Boston, Massachusetts ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D","family":"Hughes","sequence":"additional","affiliation":[{"name":"Center for Biostatistics in AIDS Research (CBAR), Harvard T.H. Chan School of Public Health , Boston, Massachusetts ,","place":["USA"]},{"name":"Department of Biostatistics, Harvard T.H. Chan School of Public Health , Boston, Massachusetts ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4773-2535","authenticated-orcid":false,"given":"Katherine","family":"Tassiopoulos","sequence":"additional","affiliation":[{"name":"Center for Biostatistics in AIDS Research (CBAR), Harvard T.H. Chan School of Public Health , Boston, Massachusetts ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1934-1935","authenticated-orcid":false,"given":"Jamie O","family":"Lo","sequence":"additional","affiliation":[{"name":"Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Oregon Health and Science University School of Medicine , Portland, Oregon ,","place":["USA"]},{"name":"Division of Reproductive and Developmental Sciences, Oregon National Primate Research Center , Beaverton, Oregon ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin J","family":"Burwitz","sequence":"additional","affiliation":[{"name":"Division of Pathobiology and Immunology, Oregon National Primate Research Center , Beaverton, Oregon ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3629-7902","authenticated-orcid":false,"given":"Joseph E","family":"Rower","sequence":"additional","affiliation":[{"name":"Center for Human Toxicology, Department of Pharmacology and Toxicology, University of Utah , Salt Lake City, Utah ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6771-8138","authenticated-orcid":false,"given":"Justin R","family":"Knox","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Columbia University, Irving Medical Center , Manhattan, New York ,","place":["USA"]},{"name":"New York State Psychiatric Institute , New York, New York ,","place":["USA"]},{"name":"Department of Sociomedical Sciences, Columbia University, Mailman School of Public Health , Manhattan, New York ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A","family":"Schneider","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Chicago , Chicago, Illinois ,","place":["USA"]},{"name":"Department of Public Health Sciences, University of Chicago , Chicago, Illinois ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4931-752X","authenticated-orcid":false,"given":"Ronald J","family":"Ellis","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, University of California San Diego , La Jolla, California ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl","family":"Goodkin","sequence":"additional","affiliation":[{"name":"Advancing Clinical Therapeutics Globally for HIV\/AIDS and Other Infections (ACTG) , Chapel Hill, North Carolina 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