{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T14:53:30Z","timestamp":1785855210613,"version":"3.56.0"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004963","name":"European Union Seventh Framework Programme","doi-asserted-by":"publisher","award":["FP7\/2007\u20132013"],"award-info":[{"award-number":["FP7\/2007\u20132013"]}],"id":[{"id":"10.13039\/501100004963","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004963","name":"European Union Seventh Framework Programme","doi-asserted-by":"publisher","award":["305340"],"award-info":[{"award-number":["305340"]}],"id":[{"id":"10.13039\/501100004963","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001858","name":"Swedish Governmental Agency for Innovation Systems","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012774","name":"Innovation Fund Denmark","doi-asserted-by":"publisher","award":["8114-00005B"],"award-info":[{"award-number":["8114-00005B"]}],"id":[{"id":"10.13039\/100012774","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005416","name":"Research Council of Norway","doi-asserted-by":"publisher","award":["90456"],"award-info":[{"award-number":["90456"]}],"id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ellab-fonden, Denmark"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Necrotizing soft-tissue infections (NSTI) caused by Clostridium spp. are rare. High rates of amputation and mortality are reported, but knowledge on clinical characteristics and outcome is largely based on retrospective cohorts. The role of Clostridium spp. as part of polymicrobial NSTI is also unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>We identified all clostridial cases from the INFECT cohort, a prospective study including patients with confirmed NSTI admitted to 5 Scandinavian referral hospitals over a 4-year period. Selected parameters were compared to a control group of nonclostridial polymicrobial infections. Additionally, we analyzed polymicrobial infections with clostridial species.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Ten cases of clostridial NSTIs were identified, evenly divided between cases caused by Clostridium perfringens and Clostridium septicum. Immunodeficiency (4\/10) and penetrating trauma (3\/10) were significantly more frequent compared to polymicrobial controls. Clostridial NSTI was also associated with extremity involvement (10\/10) and severe pain (7\/9). Radiological evidence of gas (4\/7) did not distinguish clostridial from polymicrobial infections. Two patients underwent amputation, and 2 others died within 30 days. The cohort also included seven polymicrobial NSTIs with Clostridium spp., with higher rates of both comorbidity (7\/7) and 30-day mortality (4\/7).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Clostridial NSTIs were associated with extremity infection, immunodeficiency, and penetrating trauma. The cases demonstrate a wide spectrum of severity. In polymicrobial NSTIs involving Clostridium spp., the mortality was particularly high, but the pathogenetic role of clostridia in these infections is unclear.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ofid\/ofag429","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T11:23:06Z","timestamp":1783941786000},"source":"Crossref","is-referenced-by-count":0,"title":["Clinical Features of Clostridial Necrotizing Soft-tissue Infections: Analysis of a Prospective Scandinavian Cohort Study"],"prefix":"10.1093","volume":"13","author":[{"given":"Jesper Andreas","family":"Viste","sequence":"first","affiliation":[{"name":"Department of Clinical Science, University of Bergen , Bergen ,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gard Andreas","family":"Svendal","sequence":"additional","affiliation":[{"name":"Department of Clinical Science, University of Bergen , Bergen ,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steinar","family":"Skrede","sequence":"additional","affiliation":[{"name":"Department of Clinical Science, University of Bergen , Bergen ,","place":["Norway"]},{"name":"Department of Medicine, Haukeland University Hospital , Bergen ,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1147-379X","authenticated-orcid":false,"given":"Ole","family":"Hyldegaard","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Centre of Head and Orthopaedics, Hyperbaric Unit, University Hospital of Copenhagen , Rigshospitalet, Copenhagen ,","place":["Denmark"]},{"name":"Department of Clinical Medicine, University of Copenhagen , Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9916-7086","authenticated-orcid":false,"given":"Michael","family":"Nekludov","sequence":"additional","affiliation":[{"name":"Perioperative Medicine and Intensive Care, Intensive Care and Thoracic Surgery, Hyperbaric Medicine, Karolinska University Hospital \u00a0 Solna, Stockholm ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"Arnell","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Intensive Care Medicine, Sahlgrenska University Hospital , Gothenburg ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ylva","family":"Karlsson","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care, Blekinge County Hospital , Karlskrona ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Norrby-Teglund","sequence":"additional","affiliation":[{"name":"Center for Infectious Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge , Stockholm ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7441-8413","authenticated-orcid":false,"given":"Trond","family":"Bruun","sequence":"additional","affiliation":[{"name":"Department of Clinical Science, University of Bergen , Bergen ,","place":["Norway"]},{"name":"Department of Medicine, Haukeland University Hospital , Bergen ,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,7,16]]},"reference":[{"key":"2026080410184112200_ofag429-B1","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.1056\/NEJMra1600673","article-title":"Necrotizing soft-tissue 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