{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:07:57Z","timestamp":1792786077360,"version":"4.5.0"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"vor","delay-in-days":8,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K23AI185174"],"award-info":[{"award-number":["K23AI185174"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Houston Methodist Academic Institute","award":["23550001"],"award-info":[{"award-number":["23550001"]}],"id":[{"id":"https:\/\/ror.org\/027zt9171","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Candida species distribution has changed and antifungal resistance has increased since COVID-19. We determined whether these trends contributed to changes in candidemia mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In a retrospective cohort study of patients with candidemia in Houston, TX, we compared clinical characteristics, species, and resistance between 3 periods (P1, 2017\u20132019; P2, 2020\u20132022; and P3, 2023\u20132025) and assessed contribution to mortality. We compared 30-day mortality in candidemia versus bacteremia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 1275 patients with candidemia (1386 episodes), 30-day mortality increased from P1 to P2 (19.7% vs 31.9%, P &amp;lt; .001) and remained above baseline in P3 (29.8%, P &amp;lt; .001 vs P1). In contrast, 30-day mortality increased from P1 to P2 in patients with Enterobacterales (7.4% vs 9.5%, P = .004) and Staphylococcus aureus bacteremia (9.5% vs 14.3%, P &amp;lt; .001) but returned to baseline in P3 (both P &amp;gt; .05 vs P1). Mean age (62.7 \u00b1 16.0 vs 66.1 \u00b1 14.8, P = .002) and median Elixhauser Comorbidity Index (8 [IQR 5\u201312] vs 11 [IQR 6\u201315], P &amp;lt; .001) increased from P1 to P3 among candidemia patients. Proportion of ICU-onset candidemia increased from P1 to P2 (31.3% vs 40.6%, P = .02). Proportion of C. auris increased from P1 to P3 (0.5% vs 20.5%, P &amp;lt; .001). In multivariable analyses, age (OR 1.03, 95% CI 1.02\u20131.04) and ICU-onset candidemia (OR 2.08, 95%CI 1.46\u20132.98) were associated with increased mortality. In univariable analyses, C. auris and antifungal resistance were not associated with increased mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Increased post-candidemia mortality was associated in part with demographic changes and not with species or resistance changes. Factors underlying the persistent increase in post-candidemia mortality are unclear.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ofid\/ofag558","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T11:23:36Z","timestamp":1788521016000},"source":"Crossref","is-referenced-by-count":0,"title":["Contemporary Trends in Candidemia: Mortality, Species, and Antifungal Resistance Across Three Periods (2017\u20132025) in Houston, Texas"],"prefix":"10.1093","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-4028-3402","authenticated-orcid":false,"given":"Mary North","family":"Jones","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Houston Methodist Hospital , Houston, Texas ,","place":["USA"]},{"name":"Baylor College of Medicine Department of Medicine, , Houston, Texas ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4898-1808","authenticated-orcid":false,"given":"Masayuki","family":"Nigo","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Houston Methodist Hospital , Houston, Texas ,","place":["USA"]},{"name":"Center for Infectious Diseases, Houston Methodist Research Institute , Houston, Texas ,","place":["USA"]},{"name":"Department of Medicine, Weill Cornell Medical College , New York, New York ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4901-824X","authenticated-orcid":false,"given":"Mar\u00eda Alejandra","family":"P\u00e9rez","sequence":"additional","affiliation":[{"name":"Center for Infectious Diseases, Houston Methodist Research Institute , Houston, Texas ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7416-2366","authenticated-orcid":false,"given":"Stefano","family":"Casarin","sequence":"additional","affiliation":[{"name":"Center for Precision Surgery, Houston Methodist Research Institute , Houston, Texas ,","place":["USA"]},{"name":"LaSIE, UMR 7356, CNRS, La Rochelle Universit\u00e9 , La Rochelle ,","place":["France"]},{"name":"Department of Surgery, Weill Cornell Medical College , New York, New York ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-8107-9735","authenticated-orcid":false,"given":"Aarjav","family":"Sanghvi","sequence":"additional","affiliation":[{"name":"Center for Health Data Science and Analytics, Houston Methodist Hospital , Houston, Texas ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1106-171X","authenticated-orcid":false,"given":"Stephen L","family":"Jones","sequence":"additional","affiliation":[{"name":"Center for Health Data Science and Analytics, Houston Methodist Hospital , Houston, Texas ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David B","family":"Corry","sequence":"additional","affiliation":[{"name":"Department of Medicine, Baylor College of Medicine , Houston, Texas ,","place":["USA"]},{"name":"Department of Pathology and Immunology, Baylor College of Medicine , Houston, Texas ,","place":["USA"]},{"name":"Michael E. DeBakey Department of Veterans Affairs Medical Center, Center for Translational Research on Inflammatory Diseases (CTRID) , Houston, Texas ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9054-9774","authenticated-orcid":false,"given":"Cesar A","family":"Arias","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Houston Methodist Hospital , Houston, Texas ,","place":["USA"]},{"name":"Center for Infectious Diseases, Houston Methodist Research Institute , Houston, Texas ,","place":["USA"]},{"name":"Department of Medicine, Weill Cornell Medical College , New York, New York ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9277-6046","authenticated-orcid":false,"given":"Max W","family":"Adelman","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Houston 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