{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T10:07:58Z","timestamp":1789726078024,"version":"4.0.1"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Infrequent standard-of-care (SOC) testing for respiratory syncytial virus (RSV) in adults with acute respiratory illness (ARI) contributes to underestimated disease burden.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We compared RSV prevalence and RSV vaccine effectiveness (VE) among 14 044 adults \u226560 years with ARI emergency department (ED)\/hospital admissions receiving SOC RSV testing vs those with SOC or salvaged respiratory specimen RSV testing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>RSV was identified in 139 (0.99%) specimens by SOC testing alone vs 483 (3.44%) via SOC combined with salvage testing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Precision of VE against RSV-related ARI ED\/hospital admissions improved substantially with inclusion of salvage testing compared to SOC testing alone (92% [67%\u201398%] vs 90% [29%\u201399%]).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ofid\/ofag572","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T13:10:24Z","timestamp":1788354624000},"source":"Crossref","is-referenced-by-count":0,"title":["The Impact of Respiratory Syncytial Virus Undertesting on Estimates of Disease Burden and Vaccine Effectiveness in a Large Integrated Healthcare System"],"prefix":"10.1093","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0816-7345","authenticated-orcid":false,"given":"Bradley K","family":"Ackerson","sequence":"first","affiliation":[{"name":"Department of Research and Evaluation, Kaiser Permanente Southern California , Pasadena, California 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,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6108-9198","authenticated-orcid":false,"given":"Jeff","family":"Slezak","sequence":"additional","affiliation":[{"name":"Department of Research and Evaluation, Kaiser Permanente Southern California , Pasadena, California ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vennis","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Research and Evaluation, Kaiser Permanente Southern California , Pasadena, California ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Liu","sequence":"additional","affiliation":[{"name":"Data Sciences, Pfizer , New York, New York 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,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Banshri","family":"Kapadia","sequence":"additional","affiliation":[{"name":"Department of Research and Evaluation, Kaiser Permanente Southern California , Pasadena, California ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2386-9967","authenticated-orcid":false,"given":"Brigitte C","family":"Spence","sequence":"additional","affiliation":[{"name":"Department of Research and Evaluation, Kaiser Permanente Southern California , Pasadena, California ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph A","family":"Lewnard","sequence":"additional","affiliation":[{"name":"Divisions of Epidemiology, and Infectious Diseases and Vaccinology, School of Public Health, University of California , Berkeley, California ,","place":["USA"]},{"name":"Center for Computational Biology, College of Engineering, University of California , Berkeley, California ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregg","family":"Davis","sequence":"additional","affiliation":[{"name":"Department of Research and Evaluation, Kaiser Permanente Southern California , Pasadena, California ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2595-1860","authenticated-orcid":false,"given":"Evan J","family":"Zasowski","sequence":"additional","affiliation":[{"name":"Research and Development, Pfizer , New York, New York ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Aragones","sequence":"additional","affiliation":[{"name":"Department of Research and Evaluation, Kaiser Permanente Southern California , Pasadena, California 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