{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T10:46:46Z","timestamp":1792579606376,"version":"4.5.0"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:00:00Z","timestamp":1791158400000},"content-version":"vor","delay-in-days":6,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"NHMRC","doi-asserted-by":"publisher","award":["GNT2033299"],"award-info":[{"award-number":["GNT2033299"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>HIV pre-exposure prophylaxis (PrEP) has reduced HIV incidence among men who have sex with men (MSM), but bacterial sexually transmitted infections (STIs) remain common, with limited data comparing regimens.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective cohort study was conducted at Melbourne Sexual Health Centre, Australia (2024\u20132025). MSM aged \u226518 reporting PrEP use (daily, event-driven, or switching) who were tested for chlamydia, gonorrhea, or syphilis were included. Positivity was assessed at first consultation (baseline); incidence was assessed among those with \u22652 tests \u226530 days apart. Logistic and Poisson regression estimated associations and incidence rate ratios.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 3229 PrEP users (median age 33, IQR 29\u201339), 51.0% were daily, 43.2% event-driven, and 5.8% switchers. At baseline, 33.7% (765\/2268) had any STI, with lower positivity among event-driven users (29.8%) than daily users (37.0%) or switchers (37.6%; P = .001), primarily driven by differences in gonorrhea positivity. After adjustment, event-driven PrEP use was independently associated with lower odds of baseline STI positivity (aOR 0.75, 95% CI 0.62\u20130.90), while Medicare ineligibility and recent partners had higher odds. Over 700.6 person-years, any-STI incidence (39.4\/100 person-years) did not differ across regimens.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Although event-driven users had lower baseline STI positivity, incidence was similar across regimens, suggesting baseline differences reflect underlying risk profiles rather than ongoing risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ofid\/ofag643","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T11:49:35Z","timestamp":1790855375000},"source":"Crossref","is-referenced-by-count":0,"title":["Sexually Transmitted Infections Among Men Who Have Sex With Men Using Daily and Event-Driven HIV Pre-Exposure Prophylaxis: A Retrospective Cohort Study"],"prefix":"10.1093","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9568-211X","authenticated-orcid":false,"given":"Danushi","family":"Wijekoon","sequence":"first","affiliation":[{"name":"Melbourne Sexual Health Centre, Bayside Health , Melbourne, Victoria ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2560-3233","authenticated-orcid":false,"given":"Ei T","family":"Aung","sequence":"additional","affiliation":[{"name":"Melbourne Sexual Health Centre, Bayside Health , Melbourne, Victoria ,","place":["Australia"]},{"name":"School of Translational Medicine, Faculty of Medicine, Nursing and Health Sciences, Monash University , Melbourne, Victoria ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5880-5731","authenticated-orcid":false,"given":"Phyu Mon","family":"Latt","sequence":"additional","affiliation":[{"name":"Melbourne Sexual Health Centre, Bayside Health , Melbourne, Victoria ,","place":["Australia"]},{"name":"School of Translational Medicine, Faculty of Medicine, Nursing and Health Sciences, Monash University , Melbourne, Victoria ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Buchanan","sequence":"additional","affiliation":[{"name":"Melbourne Sexual Health Centre, Bayside Health , Melbourne, Victoria ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4554-3549","authenticated-orcid":false,"given":"Nyi Nyi","family":"Soe","sequence":"additional","affiliation":[{"name":"Melbourne Sexual Health Centre, Bayside Health , Melbourne, Victoria ,","place":["Australia"]},{"name":"School of Translational Medicine, Faculty of Medicine, Nursing and Health Sciences, Monash University , Melbourne, Victoria ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1766-0657","authenticated-orcid":false,"given":"Eric P F","family":"Chow","sequence":"additional","affiliation":[{"name":"Melbourne Sexual Health Centre, Bayside Health , Melbourne, Victoria ,","place":["Australia"]},{"name":"School of Translational Medicine, Faculty of Medicine, Nursing and Health Sciences, Monash University , Melbourne, Victoria ,","place":["Australia"]},{"name":"Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne , Melbourne, Victoria ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,10,5]]},"reference":[{"key":"2026102106365957600_ofag643-B1","doi-asserted-by":"crossref","first-page":"e629","DOI":"10.1016\/S2352-3018(18)30215-7","article-title":"Population-level effectiveness of rapid, targeted, 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