{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:50:32Z","timestamp":1791910232527,"version":"4.3.4"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000},"content-version":"vor","delay-in-days":10,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005564","name":"Gilead Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005564","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004809","name":"Financiadora de Estudos e Projetos","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"FINEP-MCTi"},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI195133"],"award-info":[{"award-number":["R01AI195133"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Disseminated histoplasmosis is a leading AIDS-related opportunistic mycosis and carries high mortality risk. A simplified induction strategy using single high-dose of liposomal amphotericin B (L-AmB) has shown promise for disseminated disease, but persons with central nervous system (CNS) involvement were excluded from the clinical trial. We describe a 35-year-old man with advanced HIV disease (CD4 24 cells\/\u00b5L) and a high fungal burden who was diagnosed with disseminated histoplasmosis and, subsequently, culture-confirmed CNS involvement. He was administratively withdrawn from the trial when CNS involvement was noted. He was treated within a randomized trial with a single 10\u2005mg\/kg dose of L-AmB, followed by antiretroviral therapy (ART) and itraconazole consolidation therapy, with full clinical recovery, normalization of cerebrospinal fluid biochemistry findings, and microbiological clearance. This suggests that a single high-dose L-AmB induction strategy, combined with effective ART and azole consolidation therapy, may be viable in selected patients with CNS involvement.<\/jats:p>","DOI":"10.1093\/ofid\/ofag659","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T11:56:22Z","timestamp":1791374182000},"source":"Crossref","is-referenced-by-count":0,"title":["A Case of Neurohistoplasmosis Successfully Treated With Single High-Dose Liposomal Amphotericin B"],"prefix":"10.1093","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6274-1320","authenticated-orcid":false,"given":"Tarsila","family":"Vieceli","sequence":"first","affiliation":[{"name":"Department of Pathology, Universidade Federal de Ci\u00eancias da Sa\u00fade de Porto Alegre (UFCSPA) , Porto Alegre ,","place":["Brazil"]},{"name":"Infectious Diseases Service, Santa Casa de Porto Alegre , Porto Alegre ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1029-325X","authenticated-orcid":false,"given":"Renata de Bastos Ascen\u00e7o","family":"Soares","sequence":"additional","affiliation":[{"name":"Infectious Diseases Service, Hospital de Doen\u00e7as Tropicais , Goi\u00e2nia ,","place":["Brazil"]},{"name":"Department of Research and Education, Pontif\u00edcia Universidade Cat\u00f3lica de Goi\u00e1s , Goi\u00e2nia ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taiguara Fraga","family":"Guimar\u00e3es","sequence":"additional","affiliation":[{"name":"Infectious Diseases Service, Hospital de Doen\u00e7as Tropicais , Goi\u00e2nia ,","place":["Brazil"]},{"name":"Department of Research and Education, Pontif\u00edcia Universidade Cat\u00f3lica de Goi\u00e1s , Goi\u00e2nia ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o Victor Soares Coriolano","family":"Coutinho","sequence":"additional","affiliation":[{"name":"Department of Research and Education, Pontif\u00edcia Universidade Cat\u00f3lica de Goi\u00e1s , Goi\u00e2nia ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-1316-5783","authenticated-orcid":false,"given":"Debora Brenda Paes Rocha","family":"Sabino","sequence":"additional","affiliation":[{"name":"Infectious Diseases Service, Hospital de Doen\u00e7as Tropicais , Goi\u00e2nia ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4893-0541","authenticated-orcid":false,"given":"Cassia Silva","family":"de Miranda Godoy","sequence":"additional","affiliation":[{"name":"Infectious Diseases Service, Hospital de Doen\u00e7as Tropicais , Goi\u00e2nia ,","place":["Brazil"]},{"name":"Department of Research and Education, Pontif\u00edcia Universidade Cat\u00f3lica de Goi\u00e1s , Goi\u00e2nia ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3612-7305","authenticated-orcid":false,"given":"Daiane F","family":"Dalla-Lana","sequence":"additional","affiliation":[{"name":"Department of Pathology, Universidade Federal de Ci\u00eancias da Sa\u00fade de Porto Alegre (UFCSPA) , Porto Alegre ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3495-094X","authenticated-orcid":false,"given":"Luana C","family":"Bazana","sequence":"additional","affiliation":[{"name":"Department of Pathology, Universidade Federal de Ci\u00eancias da Sa\u00fade de Porto Alegre (UFCSPA) , Porto Alegre ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9431-8938","authenticated-orcid":false,"given":"Nathan C","family":"Bahr","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and International Medicine, Department of Medicine, University of Minnesota , Minneapolis, Minnesota ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6782-5395","authenticated-orcid":false,"given":"Alessandro C","family":"Pasqualotto","sequence":"additional","affiliation":[{"name":"Department of Pathology, Universidade Federal de Ci\u00eancias da Sa\u00fade de Porto Alegre (UFCSPA) , Porto Alegre ,","place":["Brazil"]},{"name":"Infectious Diseases Service, Santa Casa de Porto Alegre , Porto Alegre ,","place":["Brazil"]},{"name":"Division of Infectious Diseases and International Medicine, Department of Medicine, University of Minnesota , Minneapolis, Minnesota 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