{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T21:17:55Z","timestamp":1761513475158,"version":"3.41.2"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2016,10,28]],"date-time":"2016-10-28T00:00:00Z","timestamp":1477612800000},"content-version":"vor","delay-in-days":1031,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Background. \u2003In this study, we aimed to explore the clinical and epidemiological profile of all patients with hepatitis E virus (HEV) who were admitted to a tertiary care hospital in Mysore, India and to further assess various factors that influence the prognosis of these patients.<\/jats:p>\n               <jats:p>Methods. \u2003Two hundred ninety patients with HEV infection were included in the study and interviewed. They were subjected to clinical examination and laboratory investigations, including complete hemogram, renal, and liver function tests. Viral markers for HBV, HAV, HCV, and HEV by hepatitis B surface antigen, anti-HAV, anti-HCV, and anti-HEV antibodies, respectively, were done using the enzyme-linked immunosorbent assay method. Final outcome was recorded in the form of discharge or death.<\/jats:p>\n               <jats:p>Results. \u2003Males had higher (82.8%) incidence of HEV infection. Yellowish discoloration of urine was the most common symptom, and icterus was the most common sign at presentation. Hepatomegaly was most common finding on abdominal examination. Mean duration of hospital stay was higher among diabetics (10 days vs 7.11 \u00b1 3.52 days). Overall, mortality observed was 3.45%. A higher mean age (P = .000) and duration of hospital stay (P = .000) were associated with higher mortality. Mortality was significantly higher among patients with alcohol abuse (25% vs 0%) (P = .004). Higher mean prothrombin time-international normalised ratio (PT-INR) (1.6 \u00b1 0.13 vs 1.21 \u00b1 0.32), total bilirubin (20.3 \u00b1 5.08 vs 11.33 \u00b1 7.26 mg\/dL), and direct bilirubin (15.05 \u00b1 3.64 vs 6.35 \u00b1 3.71 mg\/dL) were associated with higher mortality, whereas lower mean serum albumin (2.6 \u00b1 0.11 vs 3.41 \u00b1 0.40 gm\/dL) was associated with higher mortality. Increase in renal parameters (ie, urea [97 \u00b1 33.48 vs 32.43 \u00b1 18.41 mg\/dL] and creatinine [2.9 \u00b1 1.38 vs 1.12 \u00b1 0.64 mg\/dL]) and electrolyte imbalances (ie, hyperkalemia [5.95 \u00b1 1.21 vs 4.29 \u00b1 0.51 mmol\/L] and hyponatremia [123 \u00b1 3.56 vs 136.04 \u00b1 2.97 mmol\/L]) were associated with higher mortality. There were 20-fold increases in mean serum glutamic-oxaloacetic transaminase (SGOT) and serum glutamic-pyruvic transaminase (SGPT) values (SGPT: SGOT = 1.148) and a 1-fold increase in mean alkaline phosphatase.<\/jats:p>\n               <jats:p>Conclusions. \u2003Higher mean age, duration of hospital stay, PT-INR, total bilirubin, direct bilirubin, blood urea, serum creatinine, potassium values, alcohol abuse, presence of ascites, and fulminant hepatitis were associated with higher mortality, whereas lower mean serum albumin and sodium values were associated with higher mortality. Diabetics had a higher mean duration of hospital stay.<\/jats:p>","DOI":"10.1093\/ofid\/ofu036","type":"journal-article","created":{"date-parts":[[2014,6,4]],"date-time":"2014-06-04T04:43:15Z","timestamp":1401856995000},"source":"Crossref","is-referenced-by-count":9,"title":["A Study of Viral Hepatitis E Infection in a Tertiary Care Hospital in Mysore, South India"],"prefix":"10.1093","volume":"1","author":[{"given":"Karkala Achutha Sudharshana","family":"Murthy","sequence":"first","affiliation":[{"name":"Department of Medicine, JSS Medical College Hospital, JSS University, Mysore, South India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ismailkhan Mohammed","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Medicine, JSS Medical College Hospital, JSS University, Mysore, South India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pura Krishnamurthy","family":"Kiran","sequence":"additional","affiliation":[{"name":"Department of Medicine, JSS Medical College Hospital, JSS University, Mysore, South India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisham","family":"Hakeem","sequence":"additional","affiliation":[{"name":"Department of Medicine, JSS Medical College Hospital, JSS University, Mysore, South India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2014,6,19]]},"reference":[{"year":"2013","key":"2020081009463806700_OFU036C1"},{"key":"2020081009463806700_OFU036C2","first-page":"2548","article-title":"Acute viral hepatitis. By Jules L. Dienstag","volume-title":"Harrison's Principles of Internal Medicine","author":"Longo","year":"2012","edition":"18th ed"},{"key":"2020081009463806700_OFU036C3","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1128\/JCM.35.5.1244-1247.1997","article-title":"Seroreactivity to hepatitis E in areas where disease is not endemic","volume":"35","author":"Thomas","year":"1997","journal-title":"J Clin Microbiol"},{"key":"2020081009463806700_OFU036C4","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1086\/599319","article-title":"Epidemiology of hepatitis E virus in the United States: results from the Third National Health and Nutrition Examination Survey, 1988\u20131994.","volume":"200","author":"Kuniholm","year":"2009","journal-title":"J Infect Dis"},{"key":"2020081009463806700_OFU036C5","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/S0140-6736(88)91362-1","article-title":"Waterborne non-A, non-B hepatitis","volume":"2","author":"Ramalingaswami","year":"1988","journal-title":"Lancet"},{"key":"2020081009463806700_OFU036C6","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1093\/oxfordjournals.bmb.a072409","article-title":"Enterically transmitted non-A, non-B hepatitis","volume":"46","author":"Bradley","year":"1990","journal-title":"Br Med Bull"},{"key":"2020081009463806700_OFU036C7","first-page":"96","article-title":"Hepatitis E: enterically transmitted non-A, non-B hepatitis","volume":"10","author":"Khuroo","year":"1991","journal-title":"Indian J Gastroenterol"},{"issue":"Suppl","key":"2020081009463806700_OFU036C8","first-page":"1","article-title":"Infectious hepatitis in Delhi (1955\u201356): a critical study; 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