{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:44:32Z","timestamp":1791308672284,"version":"4.3.1"},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2016,10,5]],"date-time":"2016-10-05T00:00:00Z","timestamp":1475625600000},"content-version":"vor","delay-in-days":1008,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>In this study, we report the case of a patient with profound lymphopenia after allogenic bone marrow transplantation who developed severe progressive multifocal leukoencephalopathy. Single-agent recombinant human interleukin-7 therapy was associated with restoration of anti-John Cunningham polyomavirus (JCV) T-cell responses, JCV clearance from cerebrospinal fluid, and a dramatic clinical improvement.<\/jats:p>","DOI":"10.1093\/ofid\/ofu074","type":"journal-article","created":{"date-parts":[[2014,8,12]],"date-time":"2014-08-12T01:13:36Z","timestamp":1407806016000},"source":"Crossref","is-referenced-by-count":36,"title":["Efficacy of Recombinant Human Interleukin 7 in a Patient With Severe Lymphopenia-Related Progressive Multifocal Leukoencephalopathy"],"prefix":"10.1093","volume":"1","author":[{"given":"Jacques","family":"Gasnault","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Assistance Publique-H\u00f4pitaux de Paris (AP-HP), H\u00f4pital Bic\u00eatre, Le Kremlin-Bic\u00eatre, France"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) U1012, Facult\u00e9 de M\u00e9decine, Universit\u00e9 Paris 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France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Henri","family":"Bourhis","sequence":"additional","affiliation":[{"name":"Department of Haematology, Institut Gustave Roussy, Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Lambotte","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Assistance Publique-H\u00f4pitaux de Paris (AP-HP), H\u00f4pital Bic\u00eatre, Le Kremlin-Bic\u00eatre, France"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) U1012, Facult\u00e9 de M\u00e9decine, Universit\u00e9 Paris Sud, Le Kremlin-Bic\u00eatre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Fran\u00e7ois","family":"Delfraissy","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Assistance Publique-H\u00f4pitaux de Paris (AP-HP), H\u00f4pital Bic\u00eatre, Le Kremlin-Bic\u00eatre, 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