{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T12:49:58Z","timestamp":1756385398433,"version":"3.41.2"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2016,10,5]],"date-time":"2016-10-05T00:00:00Z","timestamp":1475625600000},"content-version":"vor","delay-in-days":1008,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Background. \u2003Hypermucoviscous Klebsiellapneumoniae (HMVKP) emerged as a cause of invasive infections in South-East (SE) Asia. It has become the most common cause of liver abscess in that region, and it is a significant causative organism in endogenous endophthalmitis and meningitis. During the past decade, cases of this uniquely virulent organism have been reported outside of SE Asia, with a propensity to affect individuals of SE Asian descent. Cases have been reported from North America including Canada.<\/jats:p>\n               <jats:p>Methods. \u2003We report a case of a patient of Filipino descent living in Canada who presented with recurrent HMVKP bacteremia in the absence of pyogenic liver abscess or other localized metastatic Klebsiella infection.<\/jats:p>\n               <jats:p>Results. \u2003Investigations identified an immunoglobulin (Ig)G2 deficiency and low IgM indicating potential common variable immunodeficiency, and administration of intravenous immunoglobulins was associated with prevention of further recurrences.<\/jats:p>\n               <jats:p>Conclusions. \u2003To our knowledge, this is the first report of HMVKP associated with predisposing antibody deficiency.<\/jats:p>","DOI":"10.1093\/ofid\/ofu080","type":"journal-article","created":{"date-parts":[[2014,8,15]],"date-time":"2014-08-15T09:46:35Z","timestamp":1408095995000},"source":"Crossref","is-referenced-by-count":7,"title":["Hypermucoviscous Klebsiella Syndrome Without Liver Abscess in a Patient With Immunoglobulin G2 Immune Deficiency"],"prefix":"10.1093","volume":"1","author":[{"given":"Asim","family":"Alsaedi","sequence":"first","affiliation":[{"name":"Departments of Internal Medicine"},{"name":"Medical Microbiology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amber","family":"Janower","sequence":"additional","affiliation":[{"name":"Departments of Internal Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin-Town","family":"Wang","sequence":"additional","affiliation":[{"name":"Taiwan National Laboratory, Taipei"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kim","family":"Nichol","sequence":"additional","affiliation":[{"name":"Diagnostic Services of Manitoba, Department of Clinical Microbiology, Winnipeg, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Karlowsky","sequence":"additional","affiliation":[{"name":"Diagnostic Services of Manitoba, Department of Clinical Microbiology, Winnipeg, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pamela","family":"Orr","sequence":"additional","affiliation":[{"name":"Departments of Internal Medicine"},{"name":"Medical Microbiology"},{"name":"Community Health Sciences, University of Manitoba, Winnipeg, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoav","family":"Keynan","sequence":"additional","affiliation":[{"name":"Departments of Internal Medicine"},{"name":"Medical Microbiology"},{"name":"Community Health Sciences, University of Manitoba, Winnipeg, Canada"},{"name":"Department of Medical Microbiology, University of Nairobi, 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