{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T18:37:32Z","timestamp":1790447852869,"version":"4.1.0"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Background. \u2003Mumps outbreaks in populations with high 2-dose measles-mumps-rubella (MMR) vaccine coverage raise the question whether a third dose of MMR vaccine (MMR3) is needed. However, data on the immunogenicity of MMR3 are limited. We assessed mumps virus neutralizing antibody levels pre- and post-MMR3 in a nonoutbreak setting.<\/jats:p>\n                  <jats:p>Methods. \u2003Mumps antibody titers were assessed at baseline, 1 month, and 1 year after MMR3 in subjects aged 18\u201328 years.<\/jats:p>\n                  <jats:p>Results. \u2003At baseline, 5 of 656 (0.8%) subjects had seronegative mumps neutralizing antibody titers and 38 (5.8%) had low titers. One year post-MMR3, these numbers declined to 3 (0.5%) and 16 (2.4%), respectively. Subjects with low baseline titers were more likely to have low 1-month and 1-year titers (R2 = 0.81\u20130.87, P &amp;lt; .0001). Compared to baseline, geometric mean titers were significantly higher at 1 month (P &amp;lt; .0001) and 1 year (P &amp;lt; .01) post-MMR3; however, reverse cumulative distribution curves showed only minimal shifts in mumps titers from baseline to 1 month and 1 year.<\/jats:p>\n                  <jats:p>Conclusions. \u2003Very few subjects had negative or low baseline mumps titers. Nonetheless, mumps titers had modest but significant increases when measured 1 month and 1 year post-MMR3. This temporary increase in titers could decrease susceptibility to disease during outbreaks, but may have limited value for routine use in vaccinated populations.<\/jats:p>","DOI":"10.1093\/ofid\/ofu094","type":"journal-article","created":{"date-parts":[[2014,9,20]],"date-time":"2014-09-20T00:24:00Z","timestamp":1411172640000},"source":"Crossref","is-referenced-by-count":59,"title":["Mumps Antibody Response in Young Adults After a Third Dose of Measles-Mumps-Rubella Vaccine"],"prefix":"10.1093","volume":"1","author":[{"given":"Amy Parker","family":"Fiebelkorn","sequence":"first","affiliation":[{"name":"National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura A.","family":"Coleman","sequence":"additional","affiliation":[{"name":"Marshfield Clinic Research Foundation, Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward A.","family":"Belongia","sequence":"additional","affiliation":[{"name":"Marshfield Clinic Research Foundation, Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra K.","family":"Freeman","sequence":"additional","affiliation":[{"name":"Marshfield Clinic Research Foundation, Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daphne","family":"York","sequence":"additional","affiliation":[{"name":"Marshfield Clinic Research Foundation, Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daoling","family":"Bi","sequence":"additional","affiliation":[{"name":"National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheryl","family":"Zhang","sequence":"additional","affiliation":[{"name":"Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurie","family":"Ngo","sequence":"additional","affiliation":[{"name":"Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Rubin","sequence":"additional","affiliation":[{"name":"Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,10,18]]},"reference":[{"key":"2020081009571349100_OFU094C1","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/B978-1-4557-0090-5.00007-0","article-title":"Mumps vaccine","volume-title":"Vaccines","author":"Rubin","year":"2013","edition":"6th ed"},{"key":"2020081009571349100_OFU094C2","first-page":"393","article-title":"Mumps vaccine","volume":"26","author":"Centers for Disease Control and 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