{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:58:24Z","timestamp":1787507904930,"version":"build-2736575974"},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2016,11,11]],"date-time":"2016-11-11T00:00:00Z","timestamp":1478822400000},"content-version":"vor","delay-in-days":680,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Intramural Research Program"},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health (NIH)","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Quantitative reverse-transcription polymerase chain reaction (qRT-PCR) is the most sensitive quantitative diagnostic assay for detection of Ebola virus in multiple body fluids. Despite the strengths of this assay, we present 2 cases of Ebola virus disease (EVD) and highlight the potential for false-negative results during the early and late stages of EVD. The first case emphasizes the low negative-predictive value of qRT-PCR during incubation and the early febrile stage of EVD, and the second case emphasizes the potential for false-negative results during recovery and late neurologic complications of EVD. Careful interpretation of test results are needed to guide difficult admission and discharge decisions in suspected or confirmed EVD.<\/jats:p>","DOI":"10.1093\/ofid\/ofv137","type":"journal-article","created":{"date-parts":[[2015,9,19]],"date-time":"2015-09-19T20:08:55Z","timestamp":1442693335000},"source":"Crossref","is-referenced-by-count":13,"title":["Interpretation of Negative Molecular Test Results in Patients With Suspected or Confirmed Ebola Virus Disease: Report of Two Cases"],"prefix":"10.1093","volume":"2","author":[{"given":"Jeffrey K.","family":"Edwards","sequence":"first","affiliation":[{"name":"M\u00e9decins Sans Fronti\u00e8res, Operational Center of Brussels, Belgium"},{"name":"Department of International Health, School of Public Health, Johns Hopkins University, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Kleine","sequence":"additional","affiliation":[{"name":"M\u00e9decins Sans Fronti\u00e8res, Operational Center of Brussels, Belgium"},{"name":"Department of Infectious Diseases and Tropical Medicine, J.W. Goethe-University Hospital, Frankfurt, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Munster","sequence":"additional","affiliation":[{"name":"Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, Montana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruggero","family":"Giuliani","sequence":"additional","affiliation":[{"name":"M\u00e9decins Sans Fronti\u00e8res, Operational Center of Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moses","family":"Massaquoi","sequence":"additional","affiliation":[{"name":"Clinton Health Initiative, Monrovia, Liberia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armand","family":"Sprecher","sequence":"additional","affiliation":[{"name":"M\u00e9decins Sans Fronti\u00e8res, Operational Center of Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel S.","family":"Chertow","sequence":"additional","affiliation":[{"name":"M\u00e9decins Sans Fronti\u00e8res, Operational Center of Brussels, Belgium"},{"name":"Department of Critical Care Medicine, Clinical Center, National Institutes of Health, Bethesda, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,9,19]]},"reference":[{"key":"2020081009271104700_OFV137C1","first-page":"548","article-title":"Ebola viral disease outbreak\u2014West Africa, 2014","volume":"63","author":"Dixon","year":"2014","journal-title":"Morb Mortal Wkly Rep"},{"key":"2020081009271104700_OFV137C2","volume-title":"Filovirus Haemorrhagic Fever Guidelines","author":"Sterk","year":"2008"},{"key":"2020081009271104700_OFV137C3","article-title":"Technical Guidelines for Integrated Disease Surveillance and Response in the African Region","author":"World Health 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