{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:14:30Z","timestamp":1753877670057,"version":"3.41.2"},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2016,11,11]],"date-time":"2016-11-11T00:00:00Z","timestamp":1478822400000},"content-version":"vor","delay-in-days":680,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004107","name":"Sabin Vaccine Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004107","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Background. \u2003The impact of meningitis outbreaks is substantial. We aim to calculate the costs of meningococcal outbreaks in Brazil and Colombia from the healthcare system perspective.<\/jats:p>\n               <jats:p>Methods. \u2003A review of the literature was performed on costs associated with meningococcal outbreak in Latin America. Structured interviews capturing information about the use of resources, expenses allocated to treatment of infection, immunization campaigns, and response activities during the outbreak and disease surveillance pre- and postoutbreak were directed at local health authorities in Brazil and Colombia to foster a greater understanding of the economic impact of meningococcal outbreaks. All costs were expressed in 2014 US values.<\/jats:p>\n               <jats:p>Results. \u2003The Vila Brandina outbreak in Brazil reported 3 cases that were associated with a total investigation and outbreak management cost of $34 425 ($11 475 per notified case), representing 2.7 more than the annual gross domestic product per capita in Brazil. In contrast, the outbreak in Cartagena de Indias in Colombia reported 6 cases at a cost of the disease response phase of $735 or 9.5% of the annual gross domestic product per capita ($123 per notified case). For the disease surveillance phase, the costs ranged from $3935 (in Cartagena de Indias) to $6667 (in Vila Brandina). Serogroups B and C were responsible for the majority of meningococcal outbreaks reported in Brazil and Colombia.<\/jats:p>\n               <jats:p>Conclusions. \u2003Findings of this study underscore the importance of meningococcal disease in the region. Future research should focus on a more detailed investigation of costs of meningococcal outbreaks covering all phases of an outbreak.<\/jats:p>","DOI":"10.1093\/ofid\/ofv167","type":"journal-article","created":{"date-parts":[[2015,11,13]],"date-time":"2015-11-13T01:28:42Z","timestamp":1447378122000},"source":"Crossref","is-referenced-by-count":6,"title":["Economic Impact of Meningococcal Outbreaks in Brazil and Colombia"],"prefix":"10.1093","volume":"2","author":[{"given":"D.","family":"Constenla","sequence":"first","affiliation":[{"name":"Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Sabin Vaccine Institute, Washington, District of Columbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Alvis Guzm\u00e1n","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n y Docencia, Fundaci\u00f3n Hospital Infantil Napole\u00f3n Franco Pareja, Grupo de Investigaci\u00f3n en Econom\u00eda de la Salud, Universidad de Cartagena, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2015,11,12]]},"reference":[{"key":"2020081009464466500_OFV167C1","first-page":"313","article-title":"Enhanced surveillance of epidemic meningococcal meningitis in Africa: a three-year experience","volume":"80","author":"World Health Organization, Geneva","year":"2005","journal-title":"Wkly Epidemiol Rec"},{"key":"2020081009464466500_OFV167C2","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/S0035-9203(02)90089-1","article-title":"Where is the meningitis belt? Defining an area at risk of epidemic meningitis in Africa","volume":"96","author":"Molesworth","year":"2002","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"2020081009464466500_OFV167C3","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1586\/14760584.2013.814879","article-title":"The current situation of meningococcal disease in Latin America and recommendations for a new case definition from the Global Meningococcal Initiative","volume":"12","author":"S\u00e1fadi","year":"2013","journal-title":"Expert Rev Vaccines"},{"key":"2020081009464466500_OFV167C4","first-page":"34","article-title":"[Enfermedad rneningoc\u00f3cica y Vamengoc BC en menores de un a\u00f1o Cuba, 1983 a 1991]","volume":"48","author":"Osvaldo","year":"1996","journal-title":"Rev Cubana Med Trop"},{"key":"2020081009464466500_OFV167C5","first-page":"8","article-title":"[Situaci\u00f3n de la enfermedad meningoc\u00f3cica en Republica Dominicana]","volume":"11","author":"Secretar\u00eda de Estado de Salud P\u00fablica y Asistencia Social. Direcci\u00f3n General de Epidemiolog\u00eda","year":"1997","journal-title":"Boletin Epidemiolog\u00eda"},{"key":"2020081009464466500_OFV167C6","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1086\/644623","article-title":"Costs for households and community perception of meningitis epidemics in Burkina Faso","volume":"49","author":"Colombini","year":"2009","journal-title":"Clin Infect Dis"},{"year":"2011","author":"World Bank","article-title":"World Development Indicators","key":"2020081009464466500_OFV167C7"},{"year":"2012","author":"International Monetary Fund","article-title":"Currency Composition of Official Foreign Exchange Reserves","key":"2020081009464466500_OFV167C8"},{"key":"2020081009464466500_OFV167C9","first-page":"539","article-title":"Estimating costs associated with a community outbreak of meningococcal disease in a Colombian Caribbean city","volume":"32","author":"Pinz\u00f3n-Redondo","year":"2014","journal-title":"J Health Population and Nutr"},{"key":"2020081009464466500_OFV167C10","doi-asserted-by":"crossref","first-page":"5474","DOI":"10.1016\/j.vaccine.2011.05.058","article-title":"Cost and impact of meningitis epidemics for the public health system in Burkina Faso","volume":"29","author":"Colombini","year":"2011","journal-title":"Vaccine"},{"year":"2010","author":"Kemp","article-title":"Cost estimate for invasive meningococcal disease outbreak control \u2013 a study in Campinas, S\u00e3o Paulo","key":"2020081009464466500_OFV167C11"}],"container-title":["Open Forum Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/ofid\/article-pdf\/2\/4\/ofv167\/33602780\/ofv167.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/ofid\/article-pdf\/2\/4\/ofv167\/33602780\/ofv167.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,10]],"date-time":"2020-08-10T14:06:18Z","timestamp":1597068378000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ofid\/article\/doi\/10.1093\/ofid\/ofv167\/2460570"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":11,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,12,1]]}},"URL":"https:\/\/doi.org\/10.1093\/ofid\/ofv167","relation":{},"ISSN":["2328-8957"],"issn-type":[{"type":"electronic","value":"2328-8957"}],"subject":[],"published-other":{"date-parts":[[2015]]},"published":{"date-parts":[[2015]]},"article-number":"ofv167"}}