{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T03:48:21Z","timestamp":1765079301051,"version":"3.41.2"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2016,11,11]],"date-time":"2016-11-11T00:00:00Z","timestamp":1478822400000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Malaria in Pregnancy Consortium"},{"DOI":"10.13039\/100000865","name":"Bill & Melinda Gates Foundation","doi-asserted-by":"crossref","award":["46099"],"award-info":[{"award-number":["46099"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100014976","name":"Liverpool School of Tropical Medicine","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100014976","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The World Health Organization recommends artemisinin-based combination therapies (ACTs) for the treatment of uncomplicated falciparum malaria in the second and third trimesters of pregnancy. We conducted a meta-analysis to compare efficacy, safety and tolerability of ACTs versus quinine and other non-ACT antimalarials. The median PCR-adjusted failure rate by days 28 to 63 in the non-ACT group was 6 (range 0\u201337) per 100 women, lower in the ACT group overall (pooled risk ratio [PRR] random effects, 0.41; 95% confidence interval [CI], 0.16\u20131.05; 6 trials), and significantly lower compared with oral quinine (PRR, 0.20; 95% CI, 0.08\u20130.49; 4 trials). There were no differences in fetal deaths and congenital abnormalities. Compared with quinine, artemisinin-based combinations therapies were associated with less tinnitus (PRR, 0.19; 95% CI, 0.03\u20131.11; 4 studies), dizziness (PRR, 0.64; 95% CI, 0.44\u20130.93; 3 trials), and vomiting (PRR, 0.33; 95% CI, 0.15\u20130.73; 3 trials). Artemisinin-based combination therapies are better than quinine in the second and third trimesters; their use should be encouraged among health workers.<\/jats:p>","DOI":"10.1093\/ofid\/ofv170","type":"journal-article","created":{"date-parts":[[2015,11,13]],"date-time":"2015-11-13T01:28:42Z","timestamp":1447378122000},"source":"Crossref","is-referenced-by-count":21,"title":["Artemisinin-Based Combination Therapy Versus Quinine or Other Combinations for Treatment of Uncomplicated Plasmodium falciparum Malaria in the Second and Third Trimester of Pregnancy: A Systematic Review and Meta-Analysis"],"prefix":"10.1093","volume":"3","author":[{"given":"Ren\u00e9e J.","family":"Burger","sequence":"first","affiliation":[{"name":"University of Amsterdam, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna M.","family":"van Eijk","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Liverpool School of Tropical Medicine, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milena","family":"Bussink","sequence":"additional","affiliation":[{"name":"University of Amsterdam, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenny","family":"Hill","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Liverpool School of Tropical Medicine, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feiko O.","family":"ter Kuile","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Liverpool School of Tropical Medicine, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2015,11,12]]},"reference":[{"key":"2020081005265527500_OFV170C1","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S1473-3099(07)70021-X","article-title":"Epidemiology and burden of malaria in pregnancy","volume":"7","author":"Desai","year":"2007","journal-title":"Lancet Infect Dis"},{"article-title":"Guidelines for the Treatment of Malaria","year":"2006","author":"World Health Organization","key":"2020081005265527500_OFV170C2"},{"key":"2020081005265527500_OFV170C3","article-title":"Guidelines for the Treatment of Malaria","author":"World Health Organization","year":"2015","edition":"3rd ed"},{"article-title":"World Malaria Report 2014","year":"2014","author":"World Health Organization","key":"2020081005265527500_OFV170C4"},{"key":"2020081005265527500_OFV170C5","doi-asserted-by":"crossref","first-page":"e1001688","DOI":"10.1371\/journal.pmed.1001688","article-title":"Women's access and provider practices for the case management of malaria during pregnancy: a systematic review and meta-analysis","volume":"11","author":"Hill","year":"2014","journal-title":"PLoS Med"},{"author":"AR Scientific INC","key":"2020081005265527500_OFV170C6","article-title":"Quilaquin\u00ae, quinine sulfate, capsules USP, 324 mg"},{"key":"2020081005265527500_OFV170C7","doi-asserted-by":"crossref","first-page":"135","DOI":"10.3855\/T2.2.135","article-title":"A randomized clinical trial comparing safety, clinical and parasitological response to artemether-lumefantrine and chlorproguanil-dapsone in treatment of uncomplicated malaria in pregnancy in Mulago hospital, Uganda","volume":"2","author":"Kaye","year":"2008","journal-title":"J Infect Dev Ctries"},{"key":"2020081005265527500_OFV170C8","doi-asserted-by":"crossref","first-page":"e253","DOI":"10.1371\/journal.pmed.0050253","article-title":"A randomised controlled trial of artemether-lumefantrine versus artesunate for uncomplicated Plasmodium falciparum treatment in pregnancy","volume":"5","author":"McGready","year":"2008","journal-title":"PLoS Med"},{"key":"2020081005265527500_OFV170C9","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1016\/S1473-3099(10)70202-4","article-title":"Efficacy and safety of artemether-lumefantrine compared with quinine in pregnant women with uncomplicated Plasmodium falciparum malaria: an open-label, randomised, non-inferiority trial","volume":"10","author":"Piola","year":"2010","journal-title":"Lancet Infect Dis"},{"key":"2020081005265527500_OFV170C10","first-page":"1289","article-title":"Randomized trial of artesunate and mefloquine in comparison with quinine sulfate to treat P. falciparum malaria pregnant women","volume":"84","author":"Bounyasong","year":"2001","journal-title":"J Med Assoc Thai"},{"key":"2020081005265527500_OFV170C11","doi-asserted-by":"crossref","first-page":"e1166","DOI":"10.1371\/journal.pone.0001166","article-title":"A randomized controlled pilot trial of azithromycin or artesunate added to sulfadoxine-pyrimethamine as treatment for malaria in pregnant women","volume":"2","author":"Kalilani","year":"2007","journal-title":"PLoS One"},{"key":"2020081005265527500_OFV170C12","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1086\/432551","article-title":"A randomized comparison of artesunate-atovaquone-proguanil versus quinine in treatment for uncomplicated falciparum malaria during pregnancy","volume":"192","author":"McGready","year":"2005","journal-title":"J Infect Dis"},{"key":"2020081005265527500_OFV170C13","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/S0035-9203(00)90235-9","article-title":"Randomized comparison of mefloquine-artesunate versus quinine in the treatment of multidrug-resistant falciparum malaria in pregnancy","volume":"94","author":"McGready","year":"2000","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"2020081005265527500_OFV170C14","doi-asserted-by":"crossref","first-page":"e5138","DOI":"10.1371\/journal.pone.0005138","article-title":"Randomized trial of artesunate+amodiaquine, sulfadoxine-pyrimethamine+amodiaquine, chlorproguanal-dapsone and SP for malaria in pregnancy in Tanzania","volume":"4","author":"Mutabingwa","year":"2009","journal-title":"PLoS One"},{"key":"2020081005265527500_OFV170C15","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1080\/01443619867038","article-title":"Randomised trial of artemether versus artemether and mefloquine for the treatment of chloroquine\/sufadoxine-pyrimethamine-resistant falciparum malaria during pregnancy","volume":"18","author":"Sowunmi","year":"1998","journal-title":"J Obstet Gynaecol"},{"key":"2020081005265527500_OFV170C16","first-page":"CD004912","article-title":"Drugs for treating uncomplicated malaria in pregnant women","author":"Orton","year":"2008","journal-title":"Cochrane Database Syst Rev"},{"author":"Malaria in Pregnancy Consortium","key":"2020081005265527500_OFV170C17","article-title":"Malaria in Pregnancy Library"},{"key":"2020081005265527500_OFV170C18","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1186\/1475-2875-11-362","article-title":"The Malaria in Pregnancy Library: a bibliometric review","volume":"11","author":"van Eijk","year":"2012","journal-title":"Malar J"},{"key":"2020081005265527500_OFV170C19","doi-asserted-by":"crossref","first-page":"e1000100","DOI":"10.1371\/journal.pmed.1000100","article-title":"The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration","volume":"6","author":"Liberati","year":"2009","journal-title":"PLoS Med"},{"key":"2020081005265527500_OFV170C20","doi-asserted-by":"crossref","first-page":"d5928","DOI":"10.1136\/bmj.d5928","article-title":"The Cochrane Collaboration's tool for assessing risk of bias in randomised trials","volume":"343","author":"Higgins","year":"2011","journal-title":"BMJ"},{"key":"2020081005265527500_OFV170C21","first-page":"151","article-title":"Selecting studies and collecting data","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions: The Cochrane Collaboration","author":"Higgins","year":"2011"},{"key":"2020081005265527500_OFV170C22","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.cct.2006.04.004","article-title":"Random-effects model for meta-analysis of clinical trials: an update","volume":"28","author":"DerSimonian","year":"2007","journal-title":"Contemp Clin Trials"},{"key":"2020081005265527500_OFV170C23","first-page":"243","article-title":"Analysing data and undertaking meta-analyses","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions: The Cochrane Collaboration","author":"Deeks","year":"2011"},{"article-title":"Uganda HIV\/AIDS Sero-behavioural Survey 2004\u20132005","year":"2006","author":"Ministry of Health Uganda, ORC Macro","key":"2020081005265527500_OFV170C24"},{"article-title":"Uganda AIDS Indicator Survey 2011","year":"2012","author":"Ministry of Health Uganda, ICF International, Centers for Disease Control and Prevention, US Agency for International Development, WHO Uganda","key":"2020081005265527500_OFV170C25"},{"key":"2020081005265527500_OFV170C26","first-page":"481","article-title":"Special topics in statistics","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions: The Cochrane Collaboration","author":"Higgins","year":"2011"},{"author":"World Health Organization","key":"2020081005265527500_OFV170C27","article-title":"Antimalarial drug efficacy"},{"key":"2020081005265527500_OFV170C28","first-page":"335","article-title":"Presenting results and \u2018Summary of findings\u2019 tables","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions: The Cochrane Collaboration","author":"Schunemann","year":"2011"},{"key":"2020081005265527500_OFV170C29","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1186\/1475-2875-11-150","article-title":"Artemether-lumefantrine to treat malaria in pregnancy is associated with reduced placental haemozoin deposition compared to quinine in a randomized controlled trial","volume":"11","author":"Muehlenbachs","year":"2012","journal-title":"Malar J"},{"key":"2020081005265527500_OFV170C30","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/1475-2875-6-15","article-title":"The safety of artemisinins during pregnancy: a pressing question","volume":"6","author":"Dellicour","year":"2007","journal-title":"Malar J"},{"key":"2020081005265527500_OFV170C31","doi-asserted-by":"crossref","first-page":"e24035","DOI":"10.1371\/journal.pone.0024035","article-title":"Intermittent screening and treatment versus intermittent preventive treatment of malaria in pregnancy: provider knowledge and acceptability","volume":"6","author":"Smith Paintain","year":"2011","journal-title":"PLoS One"},{"key":"2020081005265527500_OFV170C32","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.pt.2006.06.014","article-title":"Hypoglycemia in falciparum malaria: is fasting an unrecognized and insufficiently emphasized risk factor?","volume":"22","author":"Thien","year":"2006","journal-title":"Trends Parasitol"}],"container-title":["Open Forum Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/ofid\/article-pdf\/3\/1\/ofv170\/33599933\/ofv170.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/ofid\/article-pdf\/3\/1\/ofv170\/33599933\/ofv170.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,10]],"date-time":"2020-08-10T09:27:53Z","timestamp":1597051673000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ofid\/article\/doi\/10.1093\/ofid\/ofv170\/2460402"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11,12]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1,1]]}},"URL":"https:\/\/doi.org\/10.1093\/ofid\/ofv170","relation":{},"ISSN":["2328-8957"],"issn-type":[{"type":"electronic","value":"2328-8957"}],"subject":[],"published-other":{"date-parts":[[2016]]},"published":{"date-parts":[[2015,11,12]]},"article-number":"ofv170"}}